HitPredict

Interactor 1: ERCC6 (Q03468)
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
Gene: ERCC6

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	26496610, 26030138, 31722399
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0030182 - neuron differentiation GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1493 Hs			1 482
+	Hs
		976489 ERCC6_HUMAN (1-1493): 0: 1168: 100.00		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		1038563 CHD5_HUMAN (300-1446): 0: 783: 19.15		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1255037 CHD5_HUMAN (300-1446): 0: 783: 19.15		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		56897 CHD5_MOUSE (300-1442): 0: 764: 19.19		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Hs
		1038382 CHD4_HUMAN (303-1439): 0: 766: 18.35		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1059770 CHD4_HUMAN (303-1439): 0: 766: 18.35		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		56900 CHD5_MOUSE (300-1442): 0: 764: 19.19		HDAC2_MOUSE (1-478): 0: 664: 85.71
+	Hs
		1018465 CHD3_HUMAN (303-1446): 0: 759: 19.68		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		1018617 CHD3_HUMAN (303-1446): 0: 759: 19.68		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		140286 CHD4_MOUSE (303-1460): 0: 752: 18.67		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Mm
		936393 Q5DTP7_MOUSE (303-1460): 0: 755: 18.76		HDAC2_MOUSE (1-478): 0: 664: 85.71
+	Hs
		1038730 CHD8_HUMAN (2-1474): 0: 725: 16.46		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		229453 SMCA5_HUMAN (368-1383): 0: 698: 20.75		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Mm
		140261 SMCA4_MOUSE (228-1233): 0: 674: 19.35		HDAC1_MOUSE (1-482): 0: 672: 99.38
+	Hs
		846962 SMCA4_HUMAN (228-1324): 0: 677: 19.90		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		847037 SMCA4_HUMAN (228-1324): 0: 677: 19.90		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Dm
		332806 CHDM_DROME (281-1433): 0: 679: 17.12		HDAC1_DROME (6-477): 0: 658: 77.33
+	Dm
		1097627 ISWI_DROME (371-1394): 0: 677: 20.28		HDAC1_DROME (6-477): 0: 658: 77.33
+	Ce
		184848 CHD3_CAEEL (245-1380): 0: 684: 18.74		HDA1_CAEEL (3-455): 0: 605: 63.60
+	Hs
		177241 SMCA4_HUMAN (228-1324): 0: 677: 19.90		HDAC3_HUMAN (9-434): 0: 574: 57.94