Protein: FRS2
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)

Gene: FRS2
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q8WU20

Gene Ontology (top 5):
GO:0001702 - gastrulation with mouth forming second
GO:0001759 - organ induction
GO:0003281 - ventricular septum development
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005104 - fibroblast growth factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1053706

PTN11
Tyrosine-protein phosphatase non-receptor type 11

8

6

Small-scale

0.754

High

987796

GRB2
Growth factor receptor-bound protein 2

10

20

Small-scale

0.750

High

541611

FGFR1
Fibroblast growth factor receptor 1

8

20

Small-scale

0.750

High

1060687

SOS1
Son of sevenless homolog 1

5

2

Small-scale

0.702

High

651387

CBL
E3 ubiquitin-protein ligase CBL

3

5

Small-scale

0.664

High

641220

FGFR2
Fibroblast growth factor receptor 2

3

20

Small-scale

0.640

High

299314

FLOT1
Flotillin-1

2

2

Small-scale

0.631

High

1157008

NTRK3
NT-3 growth factor receptor

2

20

Small-scale

0.619

High

1159520

NTRK2
BDNF/NT-3 growth factors receptor

2

20

Small-scale

0.619

High

582894

EZRI
Ezrin

1

3

High-throughput

0.618

High

936398

AFAD
Afadin

1

7

High-throughput

0.618

High

1106493

GAB1
GRB2-associated-binding protein 1

1

2

Small-scale

0.618

High

1353232

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.618

High

1356245

E41LA
Band 4.1-like protein 4A

1

2

High-throughput

0.618

High

1356249

GAB2
GRB2-associated-binding protein 2

1

2

Small-scale

0.618

High

412315

NTRK1
High affinity nerve growth factor receptor

2

20

Small-scale

0.606

High

464018

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

Small-scale

0.595

High

703660

MK01
Mitogen-activated protein kinase 1

2

4

Small-scale

0.594

High

1356246

ANLN
Anillin

1

0

High-throughput

0.586

High

363617

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.584

High

375768

RASK
GTPase KRas

2

6

High-throughput

0.584

High

463673

LYN
Tyrosine-protein kinase Lyn

2

20

Small-scale

0.584

High

932105

EPHA4
Ephrin type-A receptor 4

2

11

Small-scale

0.584

High

976446

RB11A
Ras-related protein Rab-11A

2

1

High-throughput

0.584

High

978195

RHOB
Rho-related GTP-binding protein RhoB

2

16

High-throughput

0.584

High

1356248

ALK
ALK tyrosine kinase receptor

2

20

High-throughput

0.584

High

979089

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.576

High

1356247

SH2B1
SH2B adapter protein 1

1

20

Small-scale

0.575

High

1356240

SRBS1
Sorbin and SH3 domain-containing protein 1

1

12

Small-scale

0.573

High

1126727

BECN1
Beclin-1

2

0

High-throughput

0.551

High

835717

KPCI
Protein kinase C iota type

1

3

Small-scale

0.527

High

439799

INSR
Insulin receptor

1

19

Small-scale

0.501

High

691802

MK03
Mitogen-activated protein kinase 3

1

4

Small-scale

0.501

High

855700

CRK
Adapter molecule crk

1

20

Small-scale

0.501

High

1025281

CDK3
Cyclin-dependent kinase 3

1

1

High-throughput

0.481

High

1109340

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.481

High

164399

NRP1
Neuropilin-1

1

1

High-throughput

0.479

High

189738

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

221163

SPY2
Protein sprouty homolog 2

1

1

Small-scale

0.479

High

341114

DIRA3
GTP-binding protein Di-Ras3

1

3

High-throughput

0.479

High

374093

RASN
GTPase NRas

1

6

High-throughput

0.479

High

440159

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.479

High

466382

RHOC
Rho-related GTP-binding protein RhoC

1

14

High-throughput

0.479

High

484190

PGFRB
Platelet-derived growth factor receptor beta

1

13

Small-scale

0.479

High

581193

RAC2
Ras-related C3 botulinum toxin substrate 2

1

13

High-throughput

0.479

High

601388

RHOQ
Rho-related GTP-binding protein RhoQ

1

17

High-throughput

0.479

High

604124

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.479

High

631370

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

642988

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

648604

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

650319

FGFR3
Fibroblast growth factor receptor 3

1

20

High-throughput

0.479

High

710393

EPHA2
Ephrin type-A receptor 2

1

13

High-throughput

0.479

High

711919

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.479

High

715690

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

761274

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.479

High

901967

RAB9A
Ras-related protein Rab-9A

1

3

High-throughput

0.479

High

908145

KS6A3
Ribosomal protein S6 kinase alpha-3

1

2

High-throughput

0.479

High

945055

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.479

High

953582

RAC3
Ras-related C3 botulinum toxin substrate 3

1

15

High-throughput

0.479

High

955414

CDC42
Cell division control protein 42 homolog

1

18

High-throughput

0.479

High

962312

RHOA
Transforming protein RhoA

1

15

High-throughput

0.479

High

988558

RAC1
Ras-related C3 botulinum toxin substrate 1

1

15

High-throughput

0.479

High

1004143

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.479

High

1015629

RHOG
Rho-related GTP-binding protein RhoG

1

13

High-throughput

0.479

High

1041197

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1087215

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1140606

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1145036

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

1146440

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.479

High

1148366

KS6A1
Ribosomal protein S6 kinase alpha-1

1

2

High-throughput

0.479

High

1159773

OCLN
Occludin

1

1

High-throughput

0.479

High

1187509

AR13B
ADP-ribosylation factor-like protein 13B

1

1

High-throughput

0.479

High

1220692

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

1229006

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.479

High

1270919

RHOU
Rho-related GTP-binding protein RhoU

1

19

High-throughput

0.479

High

1322914

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.479

High

1356242

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1356243

RHOJ
Rho-related GTP-binding protein RhoJ

1

17

High-throughput

0.479

High

1356244

RHOF
Rho-related GTP-binding protein RhoF

1

18

High-throughput

0.479

High

226148

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

327377

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

556242

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

614713

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.458

High

845737

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.458

High

975145

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1233381

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1356241

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1356239

YJU2
Splicing factor YJU2

1

1

High-throughput

0.439

High

630904

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.437

High

1356238

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1353701

MOT10
Monocarboxylate transporter 10

1

0

High-throughput

0.426

High

139942

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

1293090

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025