HitPredict

Interactor 1: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.768

The method score is based on:

Property Details
Experiments 17692505, 17982102, 12960163, 21187066, 12456660, 23999430, 16135789, 12419806, 9096323, 23811396, 35346238, 12403783, 11567019, 18280497, 20333651, 18397880, 25074812, 25400040, 12471036, 21483817 and 6 others

more...
Identification Methods affinity chromatography technology, pull down, enzymatic study, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, experimental interaction detection
Interaction Type physical association, direct interaction, association, acetylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001223 - transcription coactivator binding
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
and 12 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 551
Hs

1 2414
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Dm
+ Dm
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024