HitPredict

Interactor 1: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Interactor 2: SUH (Q06330)
Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30)
Gene: RBPJ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.951

The method score is based on:

Property Details
Experiments 9032325, 26186194, 26496610, 25609649, 28514442, 33961781
Identification Methods two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~BTD, Ank_2~LAG1-DNAbind, Ank_2~TIG_SUH
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002437 - inflammatory response to antigenic stimulus
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 6 others

more...
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 2471
Hs

1 500
+ Mm
+ Hs
+ Mm
+ Dm
+ Mm
+ Hs
+ Mm
+ Dm
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024