Protein: ACACB
Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta)

Gene: ACACB
Organism: Homo sapiens
Interactions: 137
UniProt ID: O00763

Gene Ontology (top 5):
GO:0003989 - acetyl-CoA carboxylase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

144259

ACACA
Acetyl-CoA carboxylase 1

2

16

High-throughput

0.789

High

144240

BPL1
Biotin--protein ligase

1

0

Small-scale

0.708

High

144206

ACACB
Acetyl-CoA carboxylase 2

1

15

Small-scale

0.692

High

144300

COP1
E3 ubiquitin-protein ligase COP1

2

20

High-throughput

0.611

High

144321

M1IP1
Mid1-interacting protein 1

2

4

High-throughput

0.601

High

144255

RGS1
Regulator of G-protein signaling 1

2

0

High-throughput

0.585

High

144233

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

138793

STK25
Serine/threonine-protein kinase 25

1

13

High-throughput

0.536

High

144208

DAPK3
Death-associated protein kinase 3

1

4

High-throughput

0.536

High

144211

TACC1
Transforming acidic coiled-coil-containing protein 1

1

5

High-throughput

0.536

High

144218

NPTXR
Neuronal pentraxin receptor

1

1

High-throughput

0.536

High

144219

OXSR1
Serine/threonine-protein kinase OSR1

1

10

High-throughput

0.536

High

144225

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

2

High-throughput

0.536

High

144236

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.536

High

144237

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.536

High

144239

CDK7
Cyclin-dependent kinase 7

1

8

High-throughput

0.536

High

144247

H4
Histone H4

1

6

High-throughput

0.536

High

144251

CDKL1
Cyclin-dependent kinase-like 1

1

6

High-throughput

0.536

High

144252

CDK17
Cyclin-dependent kinase 17

1

7

High-throughput

0.536

High

144254

PPARD
Peroxisome proliferator-activated receptor delta

1

1

High-throughput

0.536

High

144260

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

6

High-throughput

0.536

High

144264

KGP1
cGMP-dependent protein kinase 1

1

12

High-throughput

0.536

High

144266

TESK1
Dual specificity testis-specific protein kinase 1

1

5

High-throughput

0.536

High

144279

TSSK4
Testis-specific serine/threonine-protein kinase 4

1

4

High-throughput

0.536

High

144302

GRK7
Rhodopsin kinase GRK7

1

7

High-throughput

0.536

High

144307

THRSP
Thyroid hormone-inducible hepatic protein

1

4

High-throughput

0.536

High

144313

VRK1
Serine/threonine-protein kinase VRK1

1

9

High-throughput

0.536

High

144322

PAK6
Serine/threonine-protein kinase PAK 6

1

12

High-throughput

0.536

High

144323

ANLN
Anillin

1

3

High-throughput

0.536

High

144324

DUS22
Dual specificity protein phosphatase 22

1

3

High-throughput

0.536

High

144328

GPC5B
G-protein coupled receptor family C group 5 member B

1

1

High-throughput

0.536

High

144330

KS6B2
Ribosomal protein S6 kinase beta-2

1

11

High-throughput

0.536

High

144339

KC1G3
Casein kinase I isoform gamma-3

1

7

High-throughput

0.536

High

144217

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.513

High

144238

WHR1
Winged helix repair factor 1

1

0

High-throughput

0.513

High

144241

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.513

High

144269

INAVA
Innate immunity activator protein

1

0

High-throughput

0.513

High

144273

ZFY27
Protrudin

1

0

High-throughput

0.513

High

144275

NT5D1
5'-nucleotidase domain-containing protein 1

1

0

High-throughput

0.513

High

144316

RM46
Large ribosomal subunit protein mL46

1

0

High-throughput

0.513

High

144318

DOCK5
Dedicator of cytokinesis protein 5

1

0

High-throughput

0.513

High

144320

ELP3
Elongator complex protein 3

1

0

High-throughput

0.513

High

144332

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

144308

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

144226

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.493

High

144286

BN3D2
RNA 5'-monophosphate methyltransferase

1

0

High-throughput

0.493

High

144329

NPAP1
Nuclear pore-associated protein 1

1

1

High-throughput

0.489

High

144210

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.480

High

142707

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

144209

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

144212

EED
Polycomb protein EED

1

13

High-throughput

0.479

High

144214

LTN1
E3 ubiquitin-protein ligase listerin

1

3

High-throughput

0.479

High

144220

EGFR
Epidermal growth factor receptor

1

9

High-throughput

0.479

High

144221

FOS
Protein c-Fos

1

1

High-throughput

0.479

High

144223

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

144224

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

144227

ARF4
ADP-ribosylation factor 4

1

11

High-throughput

0.479

High

144230

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

144232

TRI23
E3 ubiquitin-protein ligase TRIM23

1

16

High-throughput

0.479

High

144234

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

12

High-throughput

0.479

High

144243

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.479

High

144244

WDR5
WD repeat-containing protein 5

1

12

High-throughput

0.479

High

144246

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.479

High

144248

RBX1
E3 ubiquitin-protein ligase RBX1

1

6

High-throughput

0.479

High

144249

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

11

High-throughput

0.479

High

144253

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

144257

RBBP4
Histone-binding protein RBBP4

1

14

High-throughput

0.479

High

144258

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

144261

ERCC8
DNA excision repair protein ERCC-8

1

19

High-throughput

0.479

High

144262

HDAC1
Histone deacetylase 1

1

14

High-throughput

0.479

High

144263

PWP1
Periodic tryptophan protein 1 homolog

1

14

High-throughput

0.479

High

144265

RBBP5
Retinoblastoma-binding protein 5

1

13

High-throughput

0.479

High

144267

RBBP7
Histone-binding protein RBBP7

1

15

High-throughput

0.479

High

144268

SMU1
WD40 repeat-containing protein SMU1

1

12

High-throughput

0.479

High

144271

DCAF6
DDB1- and CUL4-associated factor 6

1

16

High-throughput

0.479

High

144274

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

144276

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.479

High

144277

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.479

High

144281

BCOR
BCL-6 corepressor

1

3

High-throughput

0.479

High

144284

DET1
DET1 homolog

1

4

High-throughput

0.479

High

144287

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

12

High-throughput

0.479

High

144289

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

144293

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

6

High-throughput

0.479

High

144295

WDTC1
WD and tetratricopeptide repeats protein 1

1

18

High-throughput

0.479

High

144297

ARL10
ADP-ribosylation factor-like protein 10

1

18

High-throughput

0.479

High

144298

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

144299

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

144305

DDB2
DNA damage-binding protein 2

1

20

High-throughput

0.479

High

144306

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

High-throughput

0.479

High

144309

FBXW5
F-box/WD repeat-containing protein 5

1

2

High-throughput

0.479

High

144311

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

12

High-throughput

0.479

High

144314

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

11

High-throughput

0.479

High

144315

PCGF1
Polycomb group RING finger protein 1

1

5

High-throughput

0.479

High

144319

NANOG
Homeobox protein NANOG

1

2

High-throughput

0.479

High

144325

DCA13
DDB1- and CUL4-associated factor 13

1

9

High-throughput

0.479

High

144327

WSB2
WD repeat and SOCS box-containing protein 2

1

13

High-throughput

0.479

High

144331

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

144336

FBW1A
F-box/WD repeat-containing protein 1A

1

14

High-throughput

0.479

High

144338

SAR1B
Small COPII coat GTPase SAR1B

1

20

High-throughput

0.479

High

144207

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.458

High

144245

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

144283

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.458

High

144312

TRNT1
CCA tRNA nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

144222

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.445

High

144250

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.445

High

144333

PPM1H
Protein phosphatase 1H

1

1

Small-scale

0.445

High

144213

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

13

High-throughput

0.437

High

144215

RHBT1
Rho-related BTB domain-containing protein 1

1

9

High-throughput

0.437

High

144231

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

144235

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

144272

DCA10
DDB1- and CUL4-associated factor 10

1

13

High-throughput

0.437

High

144282

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

4

Small-scale

0.437

High

144285

WDR53
WD repeat-containing protein 53

1

12

High-throughput

0.437

High

144288

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

3

High-throughput

0.437

High

144290

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.437

High

144291

WDR5B
WD repeat-containing protein 5B

1

12

High-throughput

0.437

High

144294

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.437

High

144301

POC1B
POC1 centriolar protein homolog B

1

12

High-throughput

0.437

High

144303

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

144310

PF21A
PHD finger protein 21A

1

7

High-throughput

0.437

High

144317

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

144337

ARL5A
ADP-ribosylation factor-like protein 5A

1

20

High-throughput

0.437

High

144256

LG3BP
Galectin-3-binding protein

1

4

High-throughput

0.407

High

144216

NXPH3
Neurexophilin-3

1

0

High-throughput

0.279

Low

144229

IDS
Iduronate 2-sulfatase

1

0

High-throughput

0.279

Low

144242

EVA1C
Protein eva-1 homolog C

1

0

High-throughput

0.279

Low

144270

CTSRT
Cation channel sperm-associated targeting subunit tau

1

0

High-throughput

0.279

Low

144278

TM154
Transmembrane protein 154

1

0

High-throughput

0.279

Low

144292

IFNE
Interferon epsilon

1

0

High-throughput

0.279

Low

144296

SAMD3
Sterile alpha motif domain-containing protein 3

1

0

High-throughput

0.279

Low

144304

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

144334

HPCL4
Hippocalcin-like protein 4

1

0

High-throughput

0.279

Low

144280

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.249

Low

144326

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.249

Low

144228

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.232

Low

144335

S45A2
Membrane-associated transporter protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025