HitPredict

Interactor 1: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Interactor 2: SIX2 (Q9NPC8)
Homeobox protein SIX2 (Sine oculis homeobox homolog 2)
Gene: SIX2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 291
+	Hs
		315169 TLE1_HUMAN (1-770): 0: 594: 100.00		SIX6_HUMAN (1-241): 6.29e-75: 231: 55.92
+	Hs
		311439 TLE1_HUMAN (1-770): 0: 594: 100.00		SIX3_HUMAN (1-245): 4.52e-71: 224: 57.43
+	Hs
		980881 TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Hs
		315171 TLE4_HUMAN (1-770): 0: 562: 86.27		SIX6_HUMAN (1-241): 6.29e-75: 231: 55.92
+	Hs
		980756 TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Mm
		1143691 TLE4_MOUSE (1-770): 0: 563: 86.27		SIX3_MOUSE (1-245): 3.44e-71: 224: 57.43
+	Mm
		1143964 TLE4_MOUSE (1-770): 0: 563: 86.27		SIX6_MOUSE (1-241): 3.05e-72: 224: 55.51
+	Hs
		315170 TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42		SIX6_HUMAN (1-241): 6.29e-75: 231: 55.92
+	Hs
		822627 TLE1_HUMAN (1-770): 0: 594: 100.00		LHX1_HUMAN (21-291): 4.37e-42: 151: 14.52
+	Hs
		980622 TLE1_HUMAN (1-770): 0: 594: 100.00		LHX8_HUMAN (19-283): 1.39e-40: 146: 15.83
+	Hs
		620142 TLE1_HUMAN (1-770): 0: 594: 100.00		PAX7_HUMAN (100-285): 8.75e-35: 133: 19.89
+	Hs
		839732 TLE1_HUMAN (1-770): 0: 594: 100.00		LHX2_HUMAN (26-258): 1.9e-35: 133: 16.72
+	Hs
		620144 TLE4_HUMAN (1-770): 0: 562: 86.27		PAX7_HUMAN (100-285): 8.75e-35: 133: 19.89
+	Mm
		623700 TLE4_MOUSE (1-770): 0: 563: 86.27		PAX3_MOUSE (123-285): 8.92e-27: 110: 18.94
+	Dm
		558378 GROU_DROME (1-770): 7.74e-141: 433: 59.79		SO_DROME (4-257): 1.39e-74: 235: 64.98
+	Hs
		1132994 Q5T3G3_HUMAN (1-232): 2.89e-127: 381: 95.87		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Hs
		620143 TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42		PAX7_HUMAN (100-285): 8.75e-35: 133: 19.89
+	Dm
		558386 GROU_DROME (1-770): 7.74e-141: 433: 59.79		OPTIX_DROME (4-255): 1.87e-58: 195: 44.53
+	Hs
		764630 TLE4_HUMAN (1-770): 0: 562: 86.27		CUX1_HUMAN (136-259): 8.94e-10: 61.3: 24.49
+	Hs
		764629 TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42		CUX1_HUMAN (136-259): 8.94e-10: 61.3: 24.49