Protein: HIPPO
Serine/threonine-protein kinase hippo (EC 2.7.11.1) (Drosophila homolog of MST1 and MST2) (STE20-like kinase MST) (dMST)

Gene: HIPPO, hpo
Organism: Drosophila melanogaster
Interactions: 84
UniProt ID: Q8T0S6

Gene Ontology (top 5):
GO:0001654 - eye development
GO:0001745 - compound eye morphogenesis
GO:0002011 - morphogenesis of an epithelial sheet
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1345417

HIPPO
Serine/threonine-protein kinase hippo

8

17

Small-scale

0.973

High

1345423

WARTS
Serine/threonine-protein kinase Warts

8

19

Small-scale

0.968

High

1345446

Q9W5R5
Sarcolemmal membrane-associated protein

4

20

Small-scale

0.878

High

1173280

DIAP1
Death-associated inhibitor of apoptosis 1

3

5

Small-scale

0.820

High

1345427

SAV
Scaffold protein salvador

24

20

Small-scale

0.768

High

1345421

TRC
Serine/threonine-protein kinase tricornered

1

17

Small-scale

0.747

High

1345426

Q9VCQ7
LD40758p

8

18

Small-scale

0.746

High

473560

RAP1
Ras-related protein Rap1

1

20

Small-scale

0.724

High

1345418

MOB1
MOB kinase activator-like 1

4

20

Small-scale

0.683

High

1059294

EXPA
Protein expanded

3

19

Small-scale

0.661

High

561797

MODU
DNA-binding protein modulo

1

5

High-throughput

0.656

High

1345009

KIPF
Zinc finger protein kipf

1

5

High-throughput

0.656

High

118413

M9NE33
non-specific serine/threonine protein kinase

1

20

Small-scale

0.647

High

661952

PP2A
Serine/threonine-protein phosphatase PP2A

3

20

Small-scale

0.640

High

1019330

L259
Probable multidrug resistance-associated protein lethal(2)03659

1

0

High-throughput

0.622

High

1269917

Q7KUZ5
Cyclin D, isoform D

1

8

High-throughput

0.621

High

1344373

Q8SYC0
Bruno 1, isoform D

1

8

High-throughput

0.621

High

94948

E1JGN0
MAP/microtubule affinity-regulating kinase 3

1

17

Small-scale

0.618

High

624353

CI
Transcriptional activator cubitus interruptus

1

13

Small-scale

0.618

High

1175665

Q24590
non-specific serine/threonine protein kinase

1

20

Small-scale

0.618

High

1237080

Q6NPA6
MAP/microtubule affinity-regulating kinase 3

1

17

Small-scale

0.618

High

1345419

GIT
ARF GTPase-activating protein Git

1

19

Small-scale

0.618

High

1345420

Q963E5
MAP/microtubule affinity-regulating kinase 3

1

17

Small-scale

0.618

High

1345439

RAN
GTP-binding nuclear protein Ran

1

17

High-throughput

0.618

High

832220

RS18
Small ribosomal subunit protein uS13

2

2

High-throughput

0.600

High

357437

O97468
TAR DNA-binding protein 43

1

13

High-throughput

0.590

High

660452

CDK2
Cyclin-dependent kinase 2

1

13

High-throughput

0.590

High

1265585

Q7K306
cyclin-dependent kinase

1

12

High-throughput

0.590

High

1304443

Q8IP90
Bruno 1, isoform B

1

8

High-throughput

0.590

High

1345438

Q9VXM1
LD22957p

1

8

High-throughput

0.590

High

1345436

DEFI8
Differentially expressed in FDCP 8 homolog

1

17

High-throughput

0.587

High

92288

D3DML3
Connector of kinase to AP-1, isoform E

2

20

Small-scale

0.584

High

1192901

YAP1
Transcriptional coactivator yorkie

2

20

Small-scale

0.584

High

1306230

Q8IRD5
AT25231p

2

12

Small-scale

0.584

High

1345433

Q9VQW7
Echinoid, isoform A

1

2

Small-scale

0.553

High

1345447

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.549

High

1345430

Q9VGU4
FI02822p

1

8

High-throughput

0.536

High

1345432

FGOP2
FGFR1 oncogene partner 2 homolog

2

14

Small-scale

0.533

High

198156

GBLP
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.508

High

1345422

Q9U6R9
Gamma-soluble NSF attachment protein

1

8

High-throughput

0.508

High

1345424

Q9VB23
Serine/threonine protein phosphatase 2A regulatory subunit

1

6

High-throughput

0.508

High

1345431

EF1D
Probable elongation factor 1-delta

1

1

High-throughput

0.508

High

1345440

FBXW7
F-box/WD repeat-containing protein 7

1

18

High-throughput

0.508

High

58057

A1ZBE0
Putative inorganic phosphate cotransporter

1

0

High-throughput

0.486

High

84562

B7YZT5
Phospholipase

1

1

High-throughput

0.481

High

1275110

Q7YU15
Klarsicht, isoform B

1

1

High-throughput

0.481

High

95608

E3CTP7
Epidermal growth factor receptor pathway substrate clone 15, isoform D

1

5

High-throughput

0.479

High

118288

M9ND00
Dynamin associated protein 160, isoform D

1

20

High-throughput

0.479

High

121740

M9PGB1
Rho-type guanine nucleotide exchange factor, isoform G

1

20

Small-scale

0.479

High

652057

ATC1
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

1

3

High-throughput

0.479

High

654293

DDX6
ATP-dependent RNA helicase me31b

1

10

High-throughput

0.479

High

782739

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

19

Small-scale

0.479

High

958872

ARF1
ADP-ribosylation factor 1

1

10

High-throughput

0.479

High

1174714

MERH
Moesin/ezrin/radixin homolog 2

1

14

Small-scale

0.479

High

1264074

MOB4
MOB kinase activator-like 4

1

20

Small-scale

0.479

High

1304510

Q8IPC3
ubiquitinyl hydrolase 1

1

2

Small-scale

0.479

High

1345428

Q9VDE3
LD08669p

1

20

Small-scale

0.479

High

1345429

KIBRA
Protein kibra

1

20

Small-scale

0.479

High

1345441

Q9W0H2
HECT and RLD domain containing E3 ubiquitin ligase 4, isoform A

1

20

Small-scale

0.479

High

1345444

Q9W392
T-complex protein 1 subunit beta

1

20

High-throughput

0.479

High

58580

A1ZBW6
Uncharacterized protein, isoform A

1

4

High-throughput

0.464

High

1014788

H4
Histone H4

1

3

High-throughput

0.464

High

1345425

Q9VBX5
Tubulin--tyrosine ligase-like protein 5

1

1

High-throughput

0.464

High

1345445

Q9W5E8
Split discs, isoform A

1

20

High-throughput

0.464

High

1345442

Q9W0Q4
Klarsicht, isoform A

1

1

High-throughput

0.457

High

1202297

Q59DN5
FI18025p1

1

12

High-throughput

0.439

High

1269780

Q7KUK4
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

1305220

Q8IQ71
Dikar, isoform C

1

19

High-throughput

0.439

High

1345434

Q9VT68
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.439

High

55445

A1Z9E3
Elongation factor Tu

1

3

High-throughput

0.437

High

1173206

DS
Protein dachsous

1

3

High-throughput

0.437

High

1345435

Q9VT69
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.417

High

1345448

AMOS
Basic helix-loop-helix transcription factor amos

1

4

High-throughput

0.417

High

938914

RS20
Small ribosomal subunit protein uS10

2

0

High-throughput

0.310

High

51661

NUP75
Nuclear pore complex protein Nup75

1

0

High-throughput

0.265

Low

559161

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.265

Low

662844

DISC
Protein disconnected

1

0

High-throughput

0.265

Low

1070046

Q0E9B7
DNAation factor-related protein 3, isoform A

1

0

High-throughput

0.265

Low

1196644

Q4V5M2
IP06990p

1

0

High-throughput

0.265

Low

1343500

Q8SX23
RE67967p

1

0

High-throughput

0.265

Low

1343649

Q8SX89
Kugelkern, isoform A

1

0

High-throughput

0.265

Low

1345437

Q9VUP0
AT03386p

1

0

High-throughput

0.265

Low

1345443

Q9W1A7
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025