HitPredict

Interactor 1: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Interactor 2: TF7L2 (Q9NQB0)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Gene: TCF7L2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	22304967, 37689310
Identification Methods	pull down, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0090090 - negative regulation of canonical Wnt signaling pathway GO:1990907 - beta-catenin-TCF complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 772 Hs			1 619
+	Hs
		980859 TLE3_HUMAN (1-772): 0: 583: 100.00		SOX7_HUMAN (317-610): 3.06e-44: 164: 18.27
+	Hs
		980847 TLE3_HUMAN (1-772): 0: 583: 100.00		CIC_HUMAN (43-578): 1.85e-33: 139: 15.01
+	Hs
		727851 TLE3_HUMAN (1-772): 0: 583: 100.00		SOX6_HUMAN (85-501): 1.65e-33: 138: 11.66
+	Hs
		881797 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX10_HUMAN (312-612): 6.86e-48: 176: 17.10
+	Hs
		980642 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX7_HUMAN (317-610): 3.06e-44: 164: 18.27
+	Hs
		817955 TLE3_HUMAN (1-772): 0: 583: 100.00		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		980665 TLE1_HUMAN (1-772): 0: 538: 77.42		LEF1_HUMAN (11-448): 4e-41: 155: 48.19
+	Hs
		727732 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX5_HUMAN (3-485): 3.95e-38: 152: 12.73
+	Mm
		653462 TLE4_MOUSE (1-772): 6.16e-179: 533: 80.77		LEF1_MOUSE (11-448): 4.73e-41: 155: 48.42
+	Hs
		727850 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX6_HUMAN (85-501): 1.65e-33: 138: 11.66
+	Hs
		817954 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Dm
		558384 GROU_DROME (1-772): 4.17e-136: 421: 57.20		PANG2_DROME (27-612): 7.73e-59: 215: 25.32
+	Hs
		980649 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX17_HUMAN (350-432): 1.18e-14: 78.2: 31.33
+	Hs
		980723 TLE2_HUMAN (1-772): 4.46e-145: 445: 62.10		LEF1_HUMAN (11-448): 4e-41: 155: 48.19
+	Hs
		993616 TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19		TF7L2_HUMAN (1-619): 4e-84: 277: 100.00
+	Dm
		558368 GROU_DROME (1-772): 4.17e-136: 421: 57.20		PANG1_DROME (160-612): 6.65e-34: 139: 34.12
+	Dm
		558375 GROU_DROME (1-772): 4.17e-136: 421: 57.20		DICH_DROME (227-545): 1.05e-29: 123: 14.75
+	Hs
		727734 TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19		SOX5_HUMAN (3-485): 3.95e-38: 152: 12.73
+	Hs
		817967 TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19		SOX2_HUMAN (316-613): 5.49e-27: 113: 15.69
+	Hs
		993604 TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19		SOX17_HUMAN (350-432): 1.18e-14: 78.2: 31.33