Protein: IL6RB
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)

Gene: IL6RB, IL6ST
Organism: Homo sapiens
Interactions: 71
UniProt ID: P40189

Gene Ontology (top 5):
GO:0002675 - positive regulation of acute inflammatory response
GO:0002821 - positive regulation of adaptive immune response
GO:0004896 - cytokine receptor activity
GO:0004897 - ciliary neurotrophic factor receptor activity
GO:0004915 - interleukin-6 receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

445717

IL6RA
Interleukin-6 receptor subunit alpha

6

15

Small-scale

0.932

High

532856

ONCM
Oncostatin-M

5

4

Small-scale

0.924

High

770199

PTN11
Tyrosine-protein phosphatase non-receptor type 11

5

18

Small-scale

0.909

High

616753

JAK1
Tyrosine-protein kinase JAK1

4

20

Small-scale

0.907

High

147398

SOCS3
Suppressor of cytokine signaling 3

4

20

Small-scale

0.893

High

399171

IL6
Interleukin-6

3

1

Small-scale

0.845

High

770181

IL6RB
Interleukin-6 receptor subunit beta

3

15

Small-scale

0.827

High

542649

LIF
Leukemia inhibitory factor

2

2

Small-scale

0.778

High

349939

RASK
GTPase KRas

2

20

High-throughput

0.754

High

770182

STAT3
Signal transducer and activator of transcription 3

2

8

Small-scale

0.754

High

770184

LIFR
Leukemia inhibitory factor receptor

2

16

Small-scale

0.754

High

770207

OSMR
Oncostatin-M-specific receptor subunit beta

2

16

Small-scale

0.754

High

770194

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.747

High

645939

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

1

17

Small-scale

0.724

High

666027

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.724

High

770203

CMYA5
Cardiomyopathy-associated protein 5

1

14

High-throughput

0.698

High

770204

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

4

6

High-throughput

0.683

High

548653

VAV
Proto-oncogene vav

1

11

Small-scale

0.681

High

669134

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.665

High

770214

CSEN
Calsenilin

3

2

High-throughput

0.660

High

770187

CDK9
Cyclin-dependent kinase 9

1

7

Small-scale

0.647

High

770197

TLE1
Transducin-like enhancer protein 1

1

5

Small-scale

0.637

High

238374

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

338057

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

348549

RASN
GTPase NRas

1

20

High-throughput

0.618

High

383660

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

436185

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

442787

HCK
Tyrosine-protein kinase HCK

1

14

Small-scale

0.618

High

487194

ANDR
Androgen receptor

1

5

Small-scale

0.618

High

545240

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

564435

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

601828

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

Small-scale

0.618

High

655246

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

Small-scale

0.618

High

665811

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

18

Small-scale

0.618

High

770185

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.618

High

770188

RAB25
Ras-related protein Rab-25

1

5

High-throughput

0.618

High

770189

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

770190

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

770191

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

770192

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.618

High

770193

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

770195

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

770196

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

770198

KPCD
Protein kinase C delta type

1

1

Small-scale

0.618

High

770209

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

213495

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

7

High-throughput

0.606

High

770210

KCIP1
Kv channel-interacting protein 1

2

2

High-throughput

0.606

High

770186

MAGAB
Melanoma-associated antigen 11

3

5

High-throughput

0.597

High

770201

I11RA
Interleukin-11 receptor subunit alpha

2

17

Small-scale

0.584

High

770211

FBX2
F-box only protein 2

2

13

Small-scale

0.583

High

770206

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

Small-scale

0.578

High

770183

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

7

Small-scale

0.575

High

595852

IL11
Interleukin-11

2

1

Small-scale

0.552

High

449213

LEG1
Galectin-1

1

15

High-throughput

0.536

High

770208

TMPSD
Transmembrane protease serine 13

1

6

High-throughput

0.536

High

770215

ST14
Suppressor of tumorigenicity 14 protein

1

6

High-throughput

0.536

High

131878

UPK2
Uroplakin-2

1

0

High-throughput

0.513

High

306766

VAMP5
Vesicle-associated membrane protein 5

1

0

High-throughput

0.513

High

353049

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.513

High

770202

PARM1
Prostate androgen-regulated mucin-like protein 1

1

0

High-throughput

0.513

High

770212

ASC
Apoptosis-associated speck-like protein containing a CARD

1

0

Small-scale

0.513

High

642879

CNTF
Ciliary neurotrophic factor

1

5

Small-scale

0.501

High

161033

CLGN
Calmegin

1

3

High-throughput

0.489

High

770213

UBQL1
Ubiquilin-1

1

4

High-throughput

0.481

High

129537

TRAF5
TNF receptor-associated factor 5

1

3

Small-scale

0.479

High

205127

TGON2
Trans-Golgi network integral membrane protein 2

1

12

High-throughput

0.479

High

521774

CADH1
Cadherin-1

1

13

High-throughput

0.479

High

239832

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

10

High-throughput

0.445

High

770200

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

770205

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.437

High


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Last updated: 15 Jul 2024