HitPredict

Interactor 1: ACVR1 (Q04771)
Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVR1

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 0.60 0.642

The method score is based on:

Property Details
Experiments 28847510, 10652350, 9748228
Identification Methods protein complementation assay, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0007179 - transforming growth factor beta receptor signaling pathway
GO:0030509 - BMP signaling pathway
GO:0045669 - positive regulation of osteoblast differentiation
GO:0045944 - positive regulation of transcription by RNA polymerase II
GO:0046872 - metal ion binding
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 509
Hs

1 465
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024