HitPredict

Interactor 1: RRP5 (Q05022)
rRNA biogenesis protein RRP5 (Ribosomal RNA-processing protein 5) (U3 small nucleolar RNA-associated protein RRP5) (U3 snoRNA-associated protein RRP5)
Gene: RRP5

Interactor 2: BRX1 (Q08235)
Ribosome biogenesis protein BRX1
Gene: BRX1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	16429126, 16554755, 18467557, 37968396, 22319211, 22615397, 23209026
Identification Methods	affinity chromatography technology, protein complementation assay, dihydrofolate reductase reconstruction, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000464 - endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0003723 - RNA binding GO:0005730 - nucleolus GO:0042134 - rRNA primary transcript binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1729 Sc			1 291
+	Sc
		733935 RRP5_YEAST (1-1729): 0: 1247: 100.00		RPF2_YEAST (6-282): 1.45e-61: 199: 16.84
+	Sc
		866611 RRP5_YEAST (1-1729): 0: 1247: 100.00		IMP4_YEAST (5-261): 1.73e-61: 198: 17.76
+	Sc
		754910 RRP5_YEAST (1-1729): 0: 1247: 100.00		SSF1_YEAST (10-197): 9.05e-34: 129: 15.64
+	Sc
		982915 RRP5_YEAST (1-1729): 0: 1247: 100.00		SSF2_YEAST (10-197): 8.32e-33: 127: 15.17
+	Hs
		1057982 RRP5_HUMAN (35-1717): 4.59e-129: 448: 15.89		BRX1_HUMAN (26-286): 1.92e-85: 261: 47.91
+	Hs
		1058036 RRP5_HUMAN (35-1717): 4.59e-129: 448: 15.89		RPF2_HUMAN (1-285): 3.52e-77: 238: 17.57