HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	28559284, 22645313, 29426014, 30257870
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 875 Hs			1 908
+	Hs
		1027658 HERC3_HUMAN (139-874): 0: 582: 26.85		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		983219 UBE3A_HUMAN (1-875): 0: 1058: 100.00		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		1027800 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		1027714 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		1027661 UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27		PSMD2_HUMAN (1-908): 0: 1290: 100.00
+	Hs
		1192180 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		PSMD1_HUMAN (59-845): 0: 790: 17.31
+	Hs
		1072709 UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27		PSMD1_HUMAN (59-845): 0: 790: 17.31