HitPredict

Interactor 1: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Interactor 2: PTK7 (Q13308)
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)
Gene: PTK7

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 1070
+	Hs
		441184 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		TIE1_HUMAN (55-1069): 5.14e-153: 486: 17.66
+	Hs
		384692 PTN12_HUMAN (1-780): 0: 586: 100.00		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		601500 PTN12_HUMAN (1-780): 0: 586: 100.00		FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52
+	Hs
		384127 PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		607948 PTN12_HUMAN (1-780): 0: 586: 100.00		FGFR4_HUMAN (2-127): 8.1e-14: 78.2: 17.73
+	Hs
		385757 PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		384278 PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		384330 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		616937 PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62		ALK_HUMAN (695-1067): 1.21e-52: 204: 32.90
+	Hs
		445827 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		ROS1_HUMAN (791-1061): 2.82e-53: 206: 39.07
+	Hs
		665883 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		PTK7_HUMAN (2-329): 4.66e-52: 201: 19.94
+	Mm
		665993 PTN6_MOUSE (7-361): 4.04e-130: 401: 30.71		ROS1_MOUSE (791-1061): 7.02e-53: 205: 38.71
+	Hs
		384228 PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46		NTRK1_HUMAN (555-1061): 3.09e-57: 214: 30.31
+	Hs
		445820 PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46		ROS1_HUMAN (791-1061): 2.82e-53: 206: 39.07
+	Hs
		601466 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		FGFR2_HUMAN (297-603): 8.71e-43: 170: 18.52
+	Hs
		572587 PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62		VGFR1_HUMAN (225-713): 1.05e-34: 146: 16.99
+	Hs
		507839 PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46		FGFR1_HUMAN (2-231): 7.15e-34: 142: 12.41
+	Hs
		607888 PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25		FGFR4_HUMAN (2-127): 8.1e-14: 78.2: 17.73
+	Ss
		72437 B3VK31_PIG (7-351): 3.46e-127: 393: 31.48		NTRK3_PIG (40-228): 5.72e-13: 75.5: 18.59
+	Hs
		169163 PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46		MUSK_HUMAN (130-422): 5.54e-12: 72: 21.93