HitPredict

Interactor 1: RRP45 (Q05636)
Exosome complex component RRP45 (Ribosomal RNA-processing protein 45)
Gene: RRP45

Interactor 2: RRP44 (Q08162)
Exosome complex exonuclease DIS3 (EC 3.1.13.-) (EC 3.1.26.-) (Chromosome disjunction protein 3) (Ribosomal RNA-processing protein 44)
Gene: DIS3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 12972615, 11805826, 16554755, 28877463, 17173052, 18314965, 19879841, 14759368, 12837249, 16429126, 37968396
Identification Methods coimmunoprecipitation, tandem affinity purification, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains OB_Dis3~RNase_PH, RNB~RNase_PH, OB_Dis3~RNase_PH_C
Common GO terms GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005634 - nucleus
and 6 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Last updated: 15 Jul 2024