Protein: PHF8
Histone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8)

Gene: PHF8
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q9UPP1

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0003682 - chromatin binding
GO:0003712 - transcription coregulator activity
GO:0005506 - iron ion binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

935373

H31
Histone H3.1

8

20

Small-scale

0.755

High

71278

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.691

High

165739

SET1A
Histone-lysine N-methyltransferase SETD1A

1

16

Small-scale

0.691

High

796252

MAGAA
Melanoma-associated antigen 10

3

1

High-throughput

0.667

High

590237

CCNA2
Cyclin-A2

4

0

Small-scale

0.664

High

1176199

NOL8
Nucleolar protein 8

1

0

High-throughput

0.656

High

1273966

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

3

Small-scale

0.646

High

1266896

TOPB1
DNA topoisomerase 2-binding protein 1

2

1

Small-scale

0.639

High

1086352

H31T
Histone H3.1t

3

20

Small-scale

0.635

High

1087486

H2B2E
Histone H2B type 2-E

2

17

High-throughput

0.628

High

164509

TRI66
Tripartite motif-containing protein 66

1

4

High-throughput

0.618

High

245098

BRD4
Bromodomain-containing protein 4

1

14

High-throughput

0.618

High

600258

TAF1
Transcription initiation factor TFIID subunit 1

1

14

Small-scale

0.618

High

1067196

BRD3
Bromodomain-containing protein 3

1

17

High-throughput

0.618

High

1116624

LARP7
La-related protein 7

1

3

High-throughput

0.618

High

1316937

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

1

High-throughput

0.618

High

1342841

BRD7
Bromodomain-containing protein 7

1

14

High-throughput

0.618

High

1356828

BRPF3
Bromodomain and PHD finger-containing protein 3

1

6

High-throughput

0.618

High

1357696

ZN711
Zinc finger protein 711

2

0

Small-scale

0.612

High

625640

CDK2
Cyclin-dependent kinase 2

2

3

Small-scale

0.611

High

1017467

CDC20
Cell division cycle protein 20 homolog

2

8

Small-scale

0.611

High

396057

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.602

High

488036

RARA
Retinoic acid receptor alpha

2

17

Small-scale

0.602

High

918145

H4
Histone H4

2

8

Small-scale

0.595

High

1357193

FZR1
Fizzy-related protein homolog

2

9

Small-scale

0.584

High

625099

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

Small-scale

0.561

High

256154

OBSL1
Obscurin-like protein 1

2

3

High-throughput

0.558

High

804377

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.554

High

848318

HCFC1
Host cell factor 1

1

8

Small-scale

0.554

High

987020

SUH
Recombining binding protein suppressor of hairless

1

2

High-throughput

0.554

High

124125

SPT5H
Transcription elongation factor SPT5

1

8

High-throughput

0.536

High

259316

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

4

High-throughput

0.536

High

261041

H2AY
Core histone macro-H2A.1

1

10

High-throughput

0.536

High

380881

S100B
Protein S100-B

1

1

High-throughput

0.536

High

415106

CDK1
Cyclin-dependent kinase 1

1

4

High-throughput

0.536

High

887636

APC15
Anaphase-promoting complex subunit 15

1

1

High-throughput

0.536

High

962461

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

7

High-throughput

0.536

High

963704

E2F1
Transcription factor E2F1

1

2

Small-scale

0.536

High

1029359

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.536

High

1056645

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

12

High-throughput

0.536

High

1069094

Q15156
PML-RAR protein

1

17

Small-scale

0.536

High

1082656

MK14
Mitogen-activated protein kinase 14

1

6

High-throughput

0.536

High

1132109

SNPC4
snRNA-activating protein complex subunit 4

1

5

High-throughput

0.536

High

1137593

RIF1
Telomere-associated protein RIF1

1

3

High-throughput

0.536

High

1261312

RN138
E3 ubiquitin-protein ligase RNF138

1

7

High-throughput

0.536

High

1267687

MAML1
Mastermind-like protein 1

1

3

High-throughput

0.536

High

1343576

INCE
Inner centromere protein

1

2

High-throughput

0.536

High

1355906

SPB13
Serpin B13

1

2

High-throughput

0.536

High

1357694

FBW1A
F-box/WD repeat-containing protein 1A

1

6

High-throughput

0.536

High

489345

H14
Histone H1.4

1

2

High-throughput

0.515

High

559295

H15
Histone H1.5

1

3

High-throughput

0.515

High

1300560

ARX
Homeobox protein ARX

1

6

Small-scale

0.515

High

345151

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

396299

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

422595

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.513

High

629197

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

683154

CASPE
Caspase-14

1

0

High-throughput

0.513

High

823232

DPOD2
DNA polymerase delta subunit 2

1

0

High-throughput

0.513

High

881063

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.513

High

895464

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

0

High-throughput

0.513

High

948130

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.513

High

967096

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

1019385

TRI26
Tripartite motif-containing protein 26

1

0

High-throughput

0.513

High

1046021

PKP1
Plakophilin-1

1

0

High-throughput

0.513

High

1048822

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.513

High

1062976

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.513

High

1129802

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.513

High

1162212

BRAT1
BRCA1-associated ATM activator 1

1

0

High-throughput

0.513

High

1237522

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.513

High

1266999

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.513

High

1286819

ZN653
Zinc finger protein 653

1

0

High-throughput

0.513

High

1289777

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.513

High

1328751

REN3A
Regulator of nonsense transcripts 3A

1

0

High-throughput

0.513

High

1345142

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

1349113

IL37
Interleukin-37

1

0

High-throughput

0.513

High

1350069

RCC2
Protein RCC2

1

0

High-throughput

0.513

High

1355714

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.513

High

1357693

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.513

High

902811

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

317034

KLF8
Krueppel-like factor 8

1

11

High-throughput

0.500

High

398971

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.493

High

271901

SPB7
Serpin B7

1

3

High-throughput

0.489

High

397079

PAI2
Plasminogen activator inhibitor 2

1

3

High-throughput

0.489

High

836344

KLK7
Kallikrein-7

1

1

High-throughput

0.489

High

1068701

PLEC
Plectin

1

1

High-throughput

0.489

High

1110452

KR197
Keratin-associated protein 19-7

1

1

High-throughput

0.489

High

1121509

KLH26
Kelch-like protein 26

1

2

High-throughput

0.489

High

1217459

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.489

High

1218312

SPA12
Serpin A12

1

3

High-throughput

0.489

High

1271321

EVPL
Envoplakin

1

1

High-throughput

0.489

High

1312344

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

1

High-throughput

0.489

High

125793

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

133732

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

175305

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

Small-scale

0.479

High

179886

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

4

High-throughput

0.479

High

239424

CC14B
Dual specificity protein phosphatase CDC14B

1

3

High-throughput

0.479

High

311647

SMC2
Structural maintenance of chromosomes protein 2

1

2

Small-scale

0.479

High

348247

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

434079

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

456003

PARP1
Poly [ADP-ribose] polymerase 1

1

12

High-throughput

0.479

High

486846

MYB
Transcriptional activator Myb

1

5

High-throughput

0.479

High

504968

HSP7C
Heat shock cognate 71 kDa protein

1

1

Small-scale

0.479

High

583631

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

Small-scale

0.479

High

624619

CCNE1
G1/S-specific cyclin-E1

1

1

Small-scale

0.479

High

653031

APEX1
DNA repair nuclease/redox regulator APEX1

1

3

High-throughput

0.479

High

660170

RBL1
Retinoblastoma-like protein 1

1

1

Small-scale

0.479

High

672929

CDC27
Cell division cycle protein 27 homolog

1

6

Small-scale

0.479

High

750540

COIL
Coilin

1

2

High-throughput

0.479

High

785425

ELK3
ETS domain-containing protein Elk-3

1

17

High-throughput

0.479

High

809026

YAP1
Transcriptional coactivator YAP1

1

14

High-throughput

0.479

High

828422

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

867668

BLM
RecQ-like DNA helicase BLM

1

3

Small-scale

0.479

High

893197

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

903608

WDR5
WD repeat-containing protein 5

1

9

Small-scale

0.479

High

920393

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

931940

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.479

High

952701

H33
Histone H3.3

1

20

High-throughput

0.479

High

1023027

CDC16
Cell division cycle protein 16 homolog

1

6

Small-scale

0.479

High

1042850

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1046678

KLF9
Krueppel-like factor 9

1

9

High-throughput

0.479

High

1077619

ELF2
ETS-related transcription factor Elf-2

1

15

High-throughput

0.479

High

1140856

RN123
E3 ubiquitin-protein ligase RNF123

1

7

High-throughput

0.479

High

1157239

H3C
Histone H3.3C

1

20

High-throughput

0.479

High

1189049

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1222643

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

1244569

NUP43
Nucleoporin Nup43

1

16

High-throughput

0.479

High

1269941

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1288392

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

7

High-throughput

0.479

High

1299662

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

6

Small-scale

0.479

High

1313216

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1326460

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.479

High

1354086

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

11

Small-scale

0.479

High

1354876

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1356119

CDC23
Cell division cycle protein 23 homolog

1

6

Small-scale

0.479

High

1356139

APC7
Anaphase-promoting complex subunit 7

1

6

Small-scale

0.479

High

1356168

ANC2
Anaphase-promoting complex subunit 2

1

6

Small-scale

0.479

High

1357695

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1357697

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

1

High-throughput

0.479

High

161892

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

262622

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

673445

MPIP1
M-phase inducer phosphatase 1

1

0

Small-scale

0.458

High

719233

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

1246285

CDC26
Anaphase-promoting complex subunit CDC26

1

0

Small-scale

0.458

High

1294135

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1314739

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.458

High

1328561

APC1
Anaphase-promoting complex subunit 1

1

0

Small-scale

0.458

High

1332779

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1356149

APC5
Anaphase-promoting complex subunit 5

1

0

Small-scale

0.458

High

1356159

APC4
Anaphase-promoting complex subunit 4

1

0

Small-scale

0.458

High

718320

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.445

High

922470

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.437

High

1202484

HOOK3
Protein Hook homolog 3

1

3

High-throughput

0.437

High

1220315

DHX40
Probable ATP-dependent RNA helicase DHX40

1

5

High-throughput

0.437

High

1331641

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1356999

HECD1
E3 ubiquitin-protein ligase HECTD1

1

11

High-throughput

0.437

High

1347315

PIHD1
PIH1 domain-containing protein 1

1

0

Small-scale

0.426

High

390620

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.279

Low

428651

INVO
Involucrin

1

0

High-throughput

0.279

Low

473171

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

495964

PPGB
Lysosomal protective protein

1

0

High-throughput

0.279

Low

557425

BGAL
Beta-galactosidase

1

0

High-throughput

0.279

Low

763138

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

947518

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.279

Low

964811

AMPD2
AMP deaminase 2

1

0

High-throughput

0.279

Low

994029

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.279

Low

1079070

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

1159709

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

1165502

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

1314959

LS14B
Protein LSM14 homolog B

1

0

High-throughput

0.279

Low

1357698

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

486678

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.249

Low

1245643

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024