HitPredict

Interactor 1: EMAL5 (Q05BV3)
Echinoderm microtubule-associated protein-like 5 (EMAP-5)
Gene: EML5

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ANAPC4_WD40~WD40, HELP~WD40
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1969 Hs			1 605
+	Hs
		985633 EMAL5_HUMAN (1-1969): 0: 1182: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1335715 EMAL4_HUMAN (542-1112): 3.33e-33: 142: 11.61		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		201989 WDR62_HUMAN (1642-1968): 2.57e-29: 130: 9.90		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Sc
		630844 NLE1_YEAST (19-135): 4.05e-18: 92: 21.49		NLE1_YEAST (223-580): 1.69e-77: 256: 18.81
+	Hs
		903418 WDR5_HUMAN (1561-1849): 1.83e-11: 69.8: 14.62		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		792949 WDR5_HUMAN (1561-1849): 1.83e-11: 69.8: 14.62		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		793026 KTNB1_HUMAN (721-879): 6.65e-10: 66.2: 30.46		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		903531 EMAL4_HUMAN (542-1112): 3.33e-33: 142: 11.61		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Dm
		1358859 WDS_DROME (1682-1964): 1.45e-14: 79.4: 16.43		FBXW7_DROME (414-604): 1.53e-53: 199: 30.73
+	Hs
		903174 TBL3_HUMAN (1701-1967): 2.32e-27: 123: 12.50		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		1346954 NLE1_HUMAN (1879-1969): 1.57e-18: 93.1: 17.58		NLE1_HUMAN (33-408): 1.35e-41: 159: 13.21
+	Hs
		903551 NLE1_HUMAN (1879-1969): 1.57e-18: 93.1: 17.58		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Dm
		1358845 WDS_DROME (1682-1964): 1.45e-14: 79.4: 16.43		WDS_DROME (457-605): 2.3e-37: 144: 25.16
+	Hs
		209416 WDR5_HUMAN (1561-1849): 1.83e-11: 69.8: 14.62		PLRG1_HUMAN (417-604): 2.83e-38: 150: 23.47
+	Hs
		903077 WDR5_HUMAN (1561-1849): 1.83e-11: 69.8: 14.62		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		903349 WDR5B_HUMAN (1561-1849): 1.55e-11: 69.8: 14.72		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		196984 WDR5_HUMAN (1561-1849): 1.83e-11: 69.8: 14.62		PRP4_HUMAN (387-594): 6.19e-35: 140: 23.66