HitPredict

Interactor 1: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK

Interactor 2: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.937

The method score is based on:

Property Details
Experiments 12093870, 10498607, 21822214, 21482705, 16969585, 10556826
Identification Methods affinity chromatography technology, nuclear magnetic resonance, pull down, far western blotting
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0035556 - intracellular signal transduction
GO:0043274 - phospholipase binding
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 659
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024