Protein: DUS9
Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)

Gene: DUS9, DUSP9
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q99956

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004721 - phosphoprotein phosphatase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158168

MK14
Mitogen-activated protein kinase 14

11

20

Small-scale

0.978

High

703689

MK01
Mitogen-activated protein kinase 1

8

20

Small-scale

0.964

High

691832

MK03
Mitogen-activated protein kinase 3

4

20

High-throughput

0.895

High

1153378

MK11
Mitogen-activated protein kinase 11

4

20

High-throughput

0.895

High

1163896

DUS7
Dual specificity protein phosphatase 7

3

16

High-throughput

0.861

High

1163866

DUS6
Dual specificity protein phosphatase 6

2

16

High-throughput

0.754

High

549227

CDK4
Cyclin-dependent kinase 4

1

6

High-throughput

0.698

High

891765

GSK3B
Glycogen synthase kinase-3 beta

1

12

High-throughput

0.698

High

923397

MK10
Mitogen-activated protein kinase 10

1

20

Small-scale

0.647

High

295532

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

8

High-throughput

0.618

High

1095450

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

2

High-throughput

0.618

High

1360809

ASB11
Ankyrin repeat and SOCS box protein 11

1

6

High-throughput

0.618

High

1408288

DUS9
Dual specificity protein phosphatase 9

1

15

High-throughput

0.618

High

327641

ELP1
Elongator complex protein 1

2

0

High-throughput

0.585

High

1408293

ELP3
Elongator complex protein 3

2

0

High-throughput

0.585

High

130221

PGRC1
Membrane-associated progesterone receptor component 1

3

4

Small-scale

0.585

High

631436

RAB5A
Ras-related protein Rab-5A

2

8

High-throughput

0.584

High

963363

PFD3
Prefoldin subunit 3

2

3

High-throughput

0.584

High

1404648

PFD5
Prefoldin subunit 5

2

1

High-throughput

0.584

High

1408294

PFD4
Prefoldin subunit 4

2

1

High-throughput

0.584

High

231625

PRKY
Putative serine/threonine-protein kinase PRKY

1

4

High-throughput

0.575

High

1093166

STK4
Serine/threonine-protein kinase 4

1

4

High-throughput

0.575

High

939523

FCGRN
IgG receptor FcRn large subunit p51

2

1

High-throughput

0.574

High

317914

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.536

High

1233262

ELP2
Elongator complex protein 2

1

3

High-throughput

0.536

High

1310343

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

1407753

FOXB1
Forkhead box protein B1

1

1

High-throughput

0.536

High

901008

RAB5C
Ras-related protein Rab-5C

2

8

High-throughput

0.533

High

1331241

ARL10
ADP-ribosylation factor-like protein 10

2

14

High-throughput

0.533

High

74581

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

1251949

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.494

High

300218

GLRX3
Glutaredoxin-3

1

5

High-throughput

0.479

High

333157

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.479

High

374879

RASH
GTPase HRas

1

11

High-throughput

0.479

High

418729

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

16

High-throughput

0.479

High

476019

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

16

High-throughput

0.479

High

619098

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

High-throughput

0.479

High

624573

SPEE
Spermidine synthase

1

5

High-throughput

0.479

High

716051

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

16

High-throughput

0.479

High

717959

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

5

High-throughput

0.479

High

935057

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

953639

RAC3
Ras-related C3 botulinum toxin substrate 3

1

1

High-throughput

0.479

High

960536

PSME3
Proteasome activator complex subunit 3

1

4

High-throughput

0.479

High

982126

RAP1A
Ras-related protein Rap-1A

1

9

High-throughput

0.479

High

983565

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

2

High-throughput

0.479

High

986670

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

994348

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

5

High-throughput

0.479

High

1015100

ARF5
ADP-ribosylation factor 5

1

8

High-throughput

0.479

High

1045698

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1098746

NDK3
Nucleoside diphosphate kinase 3

1

6

High-throughput

0.479

High

1226723

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

4

High-throughput

0.479

High

1334832

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1338802

FAD1
FAD synthase

1

1

High-throughput

0.479

High

1339424

NUD10
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

1

2

High-throughput

0.479

High

1384810

OTUL
Ubiquitin thioesterase otulin

1

1

High-throughput

0.479

High

1397359

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

1404885

PARK7
Parkinson disease protein 7

1

5

High-throughput

0.479

High

1408289

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

1

High-throughput

0.479

High

1408292

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1408295

ARL8B
ADP-ribosylation factor-like protein 8B

1

11

High-throughput

0.479

High

1408296

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.479

High

1408297

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1408301

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

3

High-throughput

0.479

High

1408303

PAL4A
Peptidyl-prolyl cis-trans isomerase A-like 4A

1

3

High-throughput

0.479

High

182178

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.458

High

220621

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.458

High

261864

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.458

High

291514

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

1224809

AP1AR
AP-1 complex-associated regulatory protein

1

0

High-throughput

0.458

High

1242442

WDR73
Integrator complex assembly factor WDR73

1

0

High-throughput

0.458

High

1338337

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1403560

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1408291

GOLP3
Golgi phosphoprotein 3

1

0

High-throughput

0.458

High

1408299

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.458

High

1408300

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

209100

CYB5B
Cytochrome b5 type B

1

2

High-throughput

0.437

High

257667

PRAF2
PRA1 family protein 2

1

2

High-throughput

0.437

High

467592

4F2
Amino acid transporter heavy chain SLC3A2

1

3

High-throughput

0.437

High

520710

RRAS
Ras-related protein R-Ras

1

10

High-throughput

0.437

High

602263

TMM11
Transmembrane protein 11, mitochondrial

1

2

High-throughput

0.437

High

699046

CALX
Calnexin

1

2

High-throughput

0.437

High

720026

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.437

High

724168

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.437

High

813196

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

1

High-throughput

0.437

High

956607

RAB5B
Ras-related protein Rab-5B

1

7

High-throughput

0.437

High

1203128

SGMR2
Sigma intracellular receptor 2

1

2

High-throughput

0.437

High

1228774

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

2

High-throughput

0.437

High

1395105

TMX3
Protein disulfide-isomerase TMX3

1

8

High-throughput

0.437

High

1408290

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

3

High-throughput

0.437

High

1408298

SEC63
Translocation protein SEC63 homolog

1

6

High-throughput

0.437

High

1408302

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

6

High-throughput

0.437

High

885601

PRI2
DNA primase large subunit

2

0

High-throughput

0.318

High

885556

PRI1
DNA primase small subunit

1

0

High-throughput

0.279

Low

633864

MPRD
Cation-dependent mannose-6-phosphate receptor

1

0

High-throughput

0.249

Low

1136678

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.249

Low

1143780

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.249

Low

1164529

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

1333694

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025