HitPredict

Interactor 1: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK

Interactor 2: TLR8 (Q9NR97)
Toll-like receptor 8 (CD antigen CD288)
Gene: TLR8

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	12724322, 17932028
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LRR_8~PK_Tyr_Ser-Thr, LRR_8~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0032755 - positive regulation of interleukin-6 production GO:0045087 - innate immune response
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 659 Hs			1 1041
+	Hs
		120149 BTK_HUMAN (1-659): 0: 790: 100.00		TLR4_HUMAN (37-542): 3.3e-37: 153: 17.44
+	Hs
		986400 BTK_HUMAN (1-659): 0: 790: 100.00		TLR9_HUMAN (1-244): 9.75e-17: 87.6: 18.12
+	Hs
		986405 BTK_HUMAN (1-659): 0: 790: 100.00		TLR6_HUMAN (661-770): 8.93e-10: 64.9: 26.36
+	Mm
		403461 SRC_MOUSE (164-653): 9.58e-178: 517: 35.14		TLR4_MOUSE (37-623): 2.74e-39: 159: 18.87
+	Hs
		120129 SRC_HUMAN (164-653): 1.04e-178: 520: 35.14		TLR4_HUMAN (37-542): 3.3e-37: 153: 17.44
+	At
		1325560 Y5181_ARATH (66-659): 1.67e-176: 526: 16.90		EMS1_ARATH (605-838): 1.56e-27: 123: 17.90
+	At
		1325563 Y5181_ARATH (66-659): 1.67e-176: 526: 16.90		BAME2_ARATH (550-846): 6.01e-26: 117: 14.72
+	At
		1325556 Y5181_ARATH (66-659): 1.67e-176: 526: 16.90		Y1571_ARATH (615-846): 9.02e-25: 113: 13.73
+	At
		221787 Y5181_ARATH (66-659): 1.67e-176: 526: 16.90		BAME1_ARATH (536-847): 2.33e-23: 109: 10.69
+	Hs
		179925 SRC_HUMAN (164-653): 1.04e-178: 520: 35.14		TLR3_HUMAN (385-771): 2.58e-21: 102: 17.38
+	Hs
		523168 SRC_HUMAN (164-653): 1.04e-178: 520: 35.14		TLR9_HUMAN (1-244): 9.75e-17: 87.6: 18.12
+	At
		1013333 Y2239_ARATH (117-652): 7.14e-160: 475: 14.44		BAME2_ARATH (550-846): 6.01e-26: 117: 14.72
+	Mm
		403457 SRC_MOUSE (164-653): 9.58e-178: 517: 35.14		TLR3_MOUSE (592-774): 1.2e-12: 74.5: 21.39
+	At
		1013325 Y2239_ARATH (117-652): 7.14e-160: 475: 14.44		Y1571_ARATH (615-846): 9.02e-25: 113: 13.73
+	Mm
		403459 SRC_MOUSE (164-653): 9.58e-178: 517: 35.14		TLR9_MOUSE (1-242): 3.21e-11: 69.9: 15.41
+	Hs
		179930 BLK_HUMAN (156-653): 1.82e-164: 482: 35.98		TLR3_HUMAN (385-771): 2.58e-21: 102: 17.38
+	At
		1013322 Y2239_ARATH (117-652): 7.14e-160: 475: 14.44		PEPR2_ARATH (1-238): 1.66e-19: 96.9: 16.74
+	Hs
		237456 LYN_HUMAN (154-653): 1.58e-168: 493: 34.92		TLR2_HUMAN (596-770): 3.38e-09: 62.9: 23.30
+	Hs
		237481 BLK_HUMAN (156-653): 1.82e-164: 482: 35.98		TLR2_HUMAN (596-770): 3.38e-09: 62.9: 23.30