Interactor 1: NEP1 (Q06287)
Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.260) (18S rRNA (pseudouridine(1189)-N1)-methyltransferase) (18S rRNA Psi1189 methyltransferase) (Essential for mitotic growth protein 1) (Nucleolar essential protein 1)
Gene: EMG1

Interactor 2: NEP1 (Q06287)
Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.260) (18S rRNA (pseudouridine(1189)-N1)-methyltransferase) (18S rRNA Psi1189 methyltransferase) (Essential for mitotic growth protein 1) (Nucleolar essential protein 1)
Gene: EMG1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 18063569, 21087996, 20972225
Identification Methods pull down, x-ray crystallography, biochemical, molecular sieving
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains EMG1~EMG1
Common GO terms GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 13 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 252
Sc

1 252
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024