Protein: PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F)

Gene: PPIF
Organism: Homo sapiens
Interactions: 118
UniProt ID: P30405

Gene Ontology (top 5):
GO:0002931 - response to ischemia
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005757 - mitochondrial permeability transition pore complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

719421

PPIA
Peptidyl-prolyl cis-trans isomerase A

4

15

High-throughput

0.881

High

719491

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

10

High-throughput

0.783

High

719482

ABI2
Abl interactor 2

4

4

High-throughput

0.705

High

719451

BANP
Protein BANP

2

2

High-throughput

0.633

High

373792

RASN
GTPase NRas

1

7

High-throughput

0.618

High

374424

RASH
GTPase HRas

1

6

High-throughput

0.618

High

375219

RASK
GTPase KRas

1

6

High-throughput

0.618

High

719430

GRSF1
G-rich sequence factor 1

1

14

High-throughput

0.618

High

719469

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

5

High-throughput

0.618

High

719419

ARFP2
Arfaptin-2

2

1

High-throughput

0.606

High

719438

SYPL1
Synaptophysin-like protein 1

2

1

High-throughput

0.606

High

719427

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

2

Small-scale

0.595

High

279666

CISY
Citrate synthase, mitochondrial

2

2

High-throughput

0.584

High

348377

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

5

High-throughput

0.584

High

413264

P53
Cellular tumor antigen p53

1

4

Small-scale

0.578

High

719450

DND1
Dead end protein homolog 1

1

7

High-throughput

0.575

High

719442

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

7

High-throughput

0.571

High

719439

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

469459

SYPH
Synaptophysin

2

1

High-throughput

0.553

High

590249

MUC1
Mucin-1

2

5

High-throughput

0.553

High

719413

MAGAB
Melanoma-associated antigen 11

2

3

High-throughput

0.553

High

615487

NELFE
Negative elongation factor E

1

1

High-throughput

0.553

High

719422

RHOG
Rho-related GTP-binding protein RhoG

1

8

High-throughput

0.553

High

719458

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.549

High

480721

LEG1
Galectin-1

1

2

High-throughput

0.536

High

583472

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

6

High-throughput

0.536

High

719408

MYH9
Myosin-9

1

1

High-throughput

0.536

High

719426

KPCZ
Protein kinase C zeta type

1

3

High-throughput

0.536

High

719440

RHG31
Rho GTPase-activating protein 31

2

6

High-throughput

0.521

High

719416

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

0

High-throughput

0.513

High

421569

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.501

High

551957

ADT1
ADP/ATP translocase 1

1

3

Small-scale

0.501

High

719407

CLIP1
CAP-Gly domain-containing linker protein 1

1

8

High-throughput

0.489

High

719478

ANLN
Anillin

1

3

High-throughput

0.489

High

719409

SPB5
Serpin B5

1

4

Small-scale

0.481

High

61437

VWA8
von Willebrand factor A domain-containing protein 8

1

4

High-throughput

0.479

High

258238

TRI13
E3 ubiquitin-protein ligase TRIM13

1

7

High-throughput

0.479

High

281895

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

287244

RF1M
Peptide chain release factor 1, mitochondrial

1

3

High-throughput

0.479

High

470871

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

532391

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

536579

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

719410

MDHM
Malate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

719412

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

719415

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

719417

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.479

High

719420

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.479

High

719423

TFAM
Transcription factor A, mitochondrial

1

7

High-throughput

0.479

High

719429

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

719431

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

9

High-throughput

0.479

High

719432

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.479

High

719434

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

5

High-throughput

0.479

High

719437

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

719441

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

719445

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

719447

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

719449

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

5

High-throughput

0.479

High

719452

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

719453

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

7

High-throughput

0.479

High

719454

FAKD4
FAST kinase domain-containing protein 4

1

5

High-throughput

0.479

High

719455

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

719457

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

719462

EFGM
Elongation factor G, mitochondrial

1

7

High-throughput

0.479

High

719466

TR61B
tRNA

1

1

High-throughput

0.479

High

719467

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

2

High-throughput

0.479

High

719470

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

719472

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

2

High-throughput

0.479

High

719473

MTRFR
Mitochondrial translation release factor in rescue

1

3

High-throughput

0.479

High

719474

MTG2
Mitochondrial ribosome-associated GTPase 2

1

4

High-throughput

0.479

High

719475

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.479

High

719479

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

719481

RMND1
Required for meiotic nuclear division protein 1 homolog

1

1

High-throughput

0.479

High

719483

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

5

High-throughput

0.479

High

719485

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

3

High-throughput

0.479

High

719486

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

75148

FM25C
Protein FAM25C

1

3

High-throughput

0.470

High

719424

PRB3
Basic salivary proline-rich protein 3

1

7

High-throughput

0.470

High

66137

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

123336

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

183593

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

350799

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

361607

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

370158

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

519055

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

559879

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

719414

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

719425

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

719428

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

719433

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

719435

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

719436

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

719444

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

719456

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

719459

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

719460

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

719461

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

719463

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

719464

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

719465

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

719468

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

719471

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

719476

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

719477

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

719480

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

719484

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

719490

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

522049

BCL2
Apoptosis regulator Bcl-2

1

3

Small-scale

0.457

High

75129

FM25A
Protein FAM25A

1

3

High-throughput

0.439

High

719411

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.437

High

719418

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

4

High-throughput

0.437

High

719443

OTUD1
OTU domain-containing protein 1

1

2

High-throughput

0.437

High

719448

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.437

High

719487

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.437

High

719489

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

4

High-throughput

0.437

High

325521

YIF1A
Protein YIF1A

2

0

High-throughput

0.316

High

719446

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.316

High

719488

CIDEB
Lipid transferase CIDEB

2

0

High-throughput

0.316

High

184124

RER1
Protein RER1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025