HitPredict

Interactor 1: KHDR1 (Q07666)
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
Gene: KHDRBS1

Interactor 2: ITK (Q08881)
Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk)
Gene: ITK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.679

Property	Details
Experiments	12163161, 8985255, 8810341, 22745667
Identification Methods	enzymatic study, pull down, unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0050852 - T cell receptor signaling pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 443 Hs			1 620
+	Hs
		986367 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		BTK_HUMAN (5-619): 0: 664: 49.01
+	Mm
		403437 KHDR1_MOUSE (1-443): 0: 514: 94.36		SRC_MOUSE (95-618): 0: 539: 31.35
+	Hs
		522933 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		SRC_HUMAN (95-618): 0: 541: 31.35
+	Mm
		763394 KHDR1_MOUSE (1-443): 0: 514: 94.36		FYN_MOUSE (158-618): 9.21e-180: 521: 35.48
+	Mm
		980964 KHDR1_MOUSE (1-443): 0: 514: 94.36		YES_MOUSE (136-618): 2.97e-177: 515: 33.06
+	Hs
		442815 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		HCK_HUMAN (122-618): 0: 523: 33.86
+	Hs
		412149 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		FYN_HUMAN (158-618): 9.21e-180: 521: 35.48
+	Hs
		433330 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		YES_HUMAN (136-618): 8e-178: 516: 33.06
+	Hs
		411689 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		LCK_HUMAN (121-618): 5.56e-178: 515: 33.27
+	Hs
		454827 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		FGR_HUMAN (126-619): 8.52e-173: 503: 34.19
+	Mm
		639447 KHDR1_MOUSE (1-443): 0: 514: 94.36		LYN_MOUSE (147-618): 1.39e-168: 492: 36.67
+	Hs
		789110 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		FRK_HUMAN (144-619): 1.28e-168: 492: 33.27
+	Hs
		433719 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		LYN_HUMAN (144-618): 5.71e-167: 487: 35.19
+	Hs
		782780 KHDR1_HUMAN (1-443): 3.7e-177: 504: 100.00		CSK_HUMAN (167-620): 1.48e-148: 438: 34.63
+	Mm
		763412 KHDR2_MOUSE (100-443): 8.36e-126: 370: 61.65		FYN_MOUSE (158-618): 9.21e-180: 521: 35.48
+	Hs
		433822 KHDR2_HUMAN (99-443): 5.18e-130: 381: 60.62		LYN_HUMAN (144-618): 5.71e-167: 487: 35.19
+	Dm
		337713 Q9W255_DROME (59-398): 6.04e-96: 295: 32.35		SRC64_DROME (127-620): 2.28e-164: 482: 34.00
+	Hs
		337484 SF01_HUMAN (82-301): 6.63e-54: 192: 21.33		ABL1_HUMAN (149-619): 1.23e-160: 491: 34.87
+	Hs
		789069 SF01_HUMAN (82-301): 6.63e-54: 192: 21.33		ABL2_HUMAN (93-617): 6.2e-160: 490: 34.08