Interactor 1: MCL1 (Q07820)
Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)
Gene: MCL1
Interactor 2: BAK (Q16611)
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)
Gene: BAK1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 1.00 | 0.991 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 17097560, 20836993, 32296183, 10837489, 36346691, 26186194, 26045051, 27818144, 28514442, 15077116, 15901672, 15637055, 19483105, 33961781, 27701804, 21613222, 19148187, 18040043, 20023629, unassigned1304 and 5 others
more... |
| Identification Methods | affinity chromatography technology, two hybrid, pull down, unspecified method, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach, fluorescence polarization spectroscopy |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Bcl-2~Bcl-2 |
| Common GO terms | GO:0001836 - release of cytochrome c from mitochondria GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol GO:0008053 - mitochondrial fusion and 6 others more... |
| Homologous interactions | 18 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Mm |   |
|
|||||||||||
| + | Hs | |
 |
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Rn | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
