HitPredict

Interactor 1: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Interactor 2: TRIPC (Q14669)
E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)
Gene: TRIP12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1992
+	Hs
		125425 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		125426 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		1028813 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		WWP1_HUMAN (1038-1990): 0: 580: 16.88
+	Hs
		125406 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		992925 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		WWP1_HUMAN (1038-1990): 0: 580: 16.88
+	Hs
		125122 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		516643 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Sc
		376913 PABP_YEAST (123-203): 2.42e-12: 68.1: 22.73		TOM1_YEAST (922-1992): 0: 644: 15.37
+	Hs
		125374 SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		125491 SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		952117 SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53		WWP1_HUMAN (1038-1990): 0: 580: 16.88
+	Hs
		125430 PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		992947 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		SMUF1_HUMAN (1455-1989): 1.22e-158: 508: 18.46
+	Hs
		808143 SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22		NEDD4_HUMAN (814-1990): 2.08e-159: 528: 13.49
+	Hs
		1028631 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		HECD1_HUMAN (437-1230): 6.18e-77: 287: 15.52
+	Hs
		1028870 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		HECD1_HUMAN (437-1230): 6.18e-77: 287: 15.52
+	Hs
		1031494 PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67		HECD1_HUMAN (437-1230): 6.18e-77: 287: 15.52
+	Hs
		1028715 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		HUWE1_HUMAN (1616-1992): 2.18e-25: 118: 28.72
+	Hs
		992830 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		HUWE1_HUMAN (1616-1992): 2.18e-25: 118: 28.72
+	Hs
		952015 SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53		HUWE1_HUMAN (1616-1992): 2.18e-25: 118: 28.72