HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: KLF5 (Q13887)
Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2)
Gene: KLF5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005667 - transcription regulator complex
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 197 Hs			1 457
+	Hs
		980601 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		KLF5_HUMAN (1-457): 3.24e-124: 370: 100.00
+	Hs
		980748 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		KLF5_HUMAN (1-457): 3.24e-124: 370: 100.00
+	Hs
		993504 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		ZN383_HUMAN (78-457): 7.39e-78: 251: 16.28
+	Hs
		980959 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		KLF12_HUMAN (353-455): 4.09e-44: 160: 76.92
+	Hs
		884133 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		KLF3_HUMAN (308-455): 2.48e-37: 141: 59.33
+	Hs
		204165 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		KLF4_HUMAN (361-455): 3e-34: 135: 75.79
+	Hs
		884134 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		KLF3_HUMAN (308-455): 2.48e-37: 141: 59.33
+	Hs
		316865 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		KLF8_HUMAN (366-455): 4.48e-40: 149: 78.89
+	Hs
		993414 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		KLF1_HUMAN (356-455): 3.87e-38: 144: 73.00
+	Hs
		884139 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		KLF3_HUMAN (308-455): 2.48e-37: 141: 59.33
+	Hs
		204169 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		KLF4_HUMAN (361-455): 3e-34: 135: 75.79
+	Ce
		137695 UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47		KLF1_CAEEL (349-455): 2.77e-40: 152: 64.49