HitPredict

Interactor 1: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21336309
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0030335 - positive regulation of cell migration GO:0048471 - perinuclear region of cytoplasm and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 158 Hs			1 393
+	At
		1182691 SCE1_ARATH (2-155): 1.78e-71: 213: 66.23		KIN10_ARATH (67-393): 8.47e-123: 366: 19.34
+	Hs
		692026 UB2D3_HUMAN (4-157): 7.34e-73: 216: 35.07		MARK3_HUMAN (1-352): 8.89e-119: 363: 19.16
+	Hs
		667753 UBC9_HUMAN (1-158): 1.96e-70: 211: 100.00		CDK2_HUMAN (65-367): 2.8e-122: 357: 24.60
+	Hs
		667644 UBE2A_HUMAN (1-154): 4.1e-67: 202: 41.56		CDK2_HUMAN (65-367): 2.8e-122: 357: 24.60
+	Hs
		443294 UBC9_HUMAN (1-158): 1.96e-70: 211: 100.00		CDK1_HUMAN (65-367): 4.86e-110: 326: 26.45
+	Hs
		138820 UB2D3_HUMAN (4-157): 7.34e-73: 216: 35.07		STK25_HUMAN (50-367): 5.55e-103: 312: 31.88