HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: CLK4 (Q9HAZ1)
Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)
Gene: CLK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 494 Hs			1 481
+	Hs
		992944 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		CLK4_HUMAN (1-481): 3.31e-154: 449: 100.00
+	Hs
		1029103 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		CLK4_HUMAN (1-481): 3.31e-154: 449: 100.00
+	Hs
		833720 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		CLK1_HUMAN (1-480): 1.32e-146: 429: 78.72
+	Hs
		833728 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		CLK1_HUMAN (1-480): 1.32e-146: 429: 78.72
+	Hs
		833721 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		CLK1_HUMAN (1-480): 1.32e-146: 429: 78.72
+	Hs
		833727 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		CLK1_HUMAN (1-480): 1.32e-146: 429: 78.72
+	Hs
		833870 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		CLK2_HUMAN (1-481): 3.95e-131: 390: 55.26
+	Hs
		834026 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		CLK3_HUMAN (8-481): 1.82e-128: 388: 52.19
+	Hs
		833875 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		CLK2_HUMAN (1-481): 3.95e-131: 390: 55.26
+	Hs
		834032 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		CLK3_HUMAN (8-481): 1.82e-128: 388: 52.19
+	Hs
		833871 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		CLK2_HUMAN (1-481): 3.95e-131: 390: 55.26
+	Hs
		834027 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		CLK3_HUMAN (8-481): 1.82e-128: 388: 52.19
+	Hs
		834031 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		CLK3_HUMAN (8-481): 1.82e-128: 388: 52.19
+	Dm
		834188 Q9V3W7_DROME (3-188): 2.77e-50: 173: 39.06		DOA_DROME (18-480): 2.55e-116: 362: 46.58
+	Hs
		992764 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02
+	Hs
		1028900 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02
+	Hs
		1028543 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02
+	Hs
		993712 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02
+	Hs
		1028649 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		DYR1A_HUMAN (113-476): 2.18e-103: 327: 29.02
+	Sc
		688520 NOP4_YEAST (1-492): 1.19e-52: 190: 11.82		KNS1_YEAST (138-403): 1.17e-72: 245: 42.20