HitPredict

Interactor 1: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Interactor 2: FLOT2 (Q14254)
Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)
Gene: FLOT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 913 Hs			1 428
+	Hs
		522982 SRC_HUMAN (361-912): 1.28e-125: 391: 23.60		FLOT2_HUMAN (1-428): 5.86e-158: 454: 100.00
+	Hs
		601511 FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05		FLOT2_HUMAN (1-428): 5.86e-158: 454: 100.00
+	Hs
		507997 FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52		FLOT2_HUMAN (1-428): 5.86e-158: 454: 100.00
+	Hs
		607967 FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87		FLOT2_HUMAN (1-428): 5.86e-158: 454: 100.00
+	Hs
		1052408 NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89		FLOT2_HUMAN (1-428): 5.86e-158: 454: 100.00
+	Hs
		433351 YES_HUMAN (563-907): 1.25e-105: 339: 31.59		FLOT2_HUMAN (1-428): 5.86e-158: 454: 100.00
+	Hs
		279406 YES_HUMAN (563-907): 1.25e-105: 339: 31.59		FLOT1_HUMAN (5-417): 1.06e-121: 362: 47.49
+	Hs
		968376 ROR2_HUMAN (608-905): 1.57e-50: 194: 38.26		FLOT2_HUMAN (1-428): 5.86e-158: 454: 100.00
+	Mm
		140081 INSR_MOUSE (600-908): 1.88e-51: 198: 36.77		FLOT1_MOUSE (5-417): 1.18e-122: 364: 47.73
+	Hs
		279518 ROR2_HUMAN (608-905): 1.57e-50: 194: 38.26		FLOT1_HUMAN (5-417): 1.06e-121: 362: 47.49
+	Hs
		433259 YES_HUMAN (563-907): 1.25e-105: 339: 31.59		STOM_HUMAN (4-231): 6.87e-36: 135: 16.59
+	Hs
		508258 FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52		STML2_HUMAN (26-220): 1.09e-16: 83: 19.90
+	Hs
		385690 NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27		STML2_HUMAN (26-220): 1.09e-16: 83: 19.90
+	Mm
		1141341 IGF1R_MOUSE (600-901): 3.51e-50: 194: 37.09		PODO_MOUSE (4-219): 1.04e-24: 106: 15.74
+	Hs
		968346 ROR1_HUMAN (604-902): 1.59e-55: 209: 37.79		STML2_HUMAN (26-220): 1.09e-16: 83: 19.90