HitPredict

Interactor 1: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	22057045
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Hs			1 847
+	Hs
		855789 DDR1_HUMAN (1-913): 0: 911: 100.00		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Hs
		580989 DDR1_HUMAN (1-913): 0: 911: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		924517 DDR1_HUMAN (1-913): 0: 911: 100.00		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		507829 FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		924606 DDR2_HUMAN (20-905): 0: 843: 51.46		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		607939 FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87		FGD1_HUMAN (50-600): 1.71e-72: 258: 15.74
+	Hs
		522758 SRC_HUMAN (361-912): 1.28e-125: 391: 23.60		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		522887 SRC_HUMAN (361-912): 1.28e-125: 391: 23.60		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Dm
		993198 CAD96_DROME (363-906): 5.41e-117: 377: 23.85		GRAP_DROME (672-843): 3.76e-15: 77: 31.25
+	Hs
		580927 FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		507835 FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		580923 FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		507843 FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		580926 FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		581014 NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		609244 FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		601492 FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		507939 FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		607935 FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		924603 NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39