HitPredict

Interactor 1: RBL2 (Q08999)
Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2)
Gene: RBL2

Interactor 2: E2F4 (Q16254)
Transcription factor E2F4 (E2F-4)
Gene: E2F4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	22002537, 12401786, 17531812, 16600870, 12006580, 9343408, 21102443, 9858615, 17671431, 17159899, 23108140, 9121766, 20133863
Identification Methods	affinity chromatography technology, two hybrid, pull down, experimental interaction detection, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0007049 - cell cycle GO:1990841 - promoter-specific chromatin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1139 Hs			1 413
+	Hs
		660145 RBL1_HUMAN (51-1139): 0: 1396: 50.59		E2F4_HUMAN (1-413): 0: 528: 100.00
+	Mm
		1145491 RBL1_MOUSE (51-1139): 0: 1370: 49.82		E2F4_MOUSE (1-413): 4.62e-177: 501: 92.03
+	Hs
		963598 RBL2_HUMAN (1-1139): 0: 1591: 100.00		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	Hs
		997123 RBL2_HUMAN (1-1139): 0: 1591: 100.00		E2F5_HUMAN (304-412): 2.39e-35: 134: 39.34
+	Hs
		660138 RBL1_HUMAN (51-1139): 0: 1396: 50.59		E2F2_HUMAN (4-252): 2.04e-83: 263: 43.83
+	Hs
		660118 RBL1_HUMAN (51-1139): 0: 1396: 50.59		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	Hs
		135214 RBL1_HUMAN (51-1139): 0: 1396: 50.59		E2F3_HUMAN (5-289): 3.49e-79: 253: 36.93
+	Hs
		660143 RBL1_HUMAN (51-1139): 0: 1396: 50.59		E2F5_HUMAN (304-412): 2.39e-35: 134: 39.34
+	Mm
		527164 RB_MOUSE (762-1032): 6.63e-68: 248: 27.24		E2F4_MOUSE (1-413): 4.62e-177: 501: 92.03
+	At
		1324895 RBR1_ARATH (819-1112): 2.17e-75: 272: 23.72		E2FA_ARATH (3-298): 3.72e-103: 316: 35.33
+	At
		1325150 RBR1_ARATH (819-1112): 2.17e-75: 272: 23.72		E2FB_ARATH (4-279): 6.71e-80: 255: 33.12
+	At
		1325146 RBR1_ARATH (819-1112): 2.17e-75: 272: 23.72		E2FC_ARATH (1-226): 4.63e-77: 245: 41.30
+	Mm
		527140 RB_MOUSE (762-1032): 6.63e-68: 248: 27.24		E2F2_MOUSE (4-244): 2.59e-82: 260: 43.09
+	Hs
		414284 RB_HUMAN (775-999): 1.19e-64: 239: 29.39		E2F2_HUMAN (4-252): 2.04e-83: 263: 43.83
+	Mm
		192503 RB_MOUSE (762-1032): 6.63e-68: 248: 27.24		E2F3_MOUSE (5-255): 3.63e-78: 250: 37.55
+	Hs
		414250 RB_HUMAN (775-999): 1.19e-64: 239: 29.39		E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29
+	Hs
		135199 RB_HUMAN (775-999): 1.19e-64: 239: 29.39		E2F3_HUMAN (5-289): 3.49e-79: 253: 36.93
+	Mm
		527156 RB_MOUSE (762-1032): 6.63e-68: 248: 27.24		E2F1_MOUSE (10-278): 3.12e-69: 226: 34.19
+	Hs
		265585 RB_HUMAN (775-999): 1.19e-64: 239: 29.39		E2F6_HUMAN (17-244): 1.21e-72: 230: 34.35
+	Rn
		140344 RB_RAT (762-1032): 8.29e-66: 242: 26.91		E2F1_RAT (10-278): 2.31e-68: 224: 33.95