HitPredict

Interactor 1: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Interactor 2: ASH1L (Q9NR48)
Histone-lysine N-methyltransferase ASH1L (EC 2.1.1.359) (EC 2.1.1.367) (ASH1-like protein) (huASH1) (Absent small and homeotic disks protein 1 homolog) (Lysine N-methyltransferase 2H)
Gene: ASH1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 425 Hs			1 2969
+	Dm
		1099178 CAF1_DROME (226-419): 3.68e-29: 119: 18.36		ASH1_DROME (1729-2958): 0: 750: 31.76
+	Hs
		997839 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		EZH1_HUMAN (1696-2269): 5.96e-84: 296: 19.27
+	Mm
		936646 RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00		EZH1_MOUSE (1696-2269): 2.63e-83: 294: 18.94
+	Hs
		203672 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		SUV91_HUMAN (1976-2284): 3.24e-85: 288: 21.01
+	Mm
		222465 RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00		SUV91_MOUSE (1976-2284): 5.34e-85: 287: 20.73
+	Mm
		1141935 RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00		Q6AXH7_MOUSE (1928-2269): 1.06e-78: 280: 23.56
+	Mm
		1141929 RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00		EZH2_MOUSE (1928-2269): 1.45e-78: 279: 23.56
+	Hs
		997735 RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00		EZH2_HUMAN (1928-2269): 4.34e-78: 278: 23.84
+	Hs
		1083337 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		EZH1_HUMAN (1696-2269): 5.96e-84: 296: 19.27
+	Mm
		936647 RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20		EZH1_MOUSE (1696-2269): 2.63e-83: 294: 18.94
+	Hs
		203695 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		SUV91_HUMAN (1976-2284): 3.24e-85: 288: 21.01
+	Mm
		222466 RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20		SUV91_MOUSE (1976-2284): 5.34e-85: 287: 20.73
+	Hs
		1079986 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		EZH2_HUMAN (1928-2269): 4.34e-78: 278: 23.84
+	Mm
		1141960 RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20		Q6AXH7_MOUSE (1928-2269): 1.06e-78: 280: 23.56
+	Mm
		1141957 RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20		EZH2_MOUSE (1928-2269): 1.45e-78: 279: 23.56
+	Hs
		267764 TAF5L_HUMAN (26-422): 3e-74: 244: 22.20		EZH2_HUMAN (1928-2269): 4.34e-78: 278: 23.84
+	At
		186949 MSI1_ARATH (2-210): 3.43e-31: 125: 13.22		EZA1_ARATH (1764-2269): 3.86e-86: 305: 17.50
+	Dm
		785628 CAF1_DROME (226-419): 3.68e-29: 119: 18.36		EZ_DROME (1940-2264): 1.4e-79: 283: 22.16
+	Hs
		903656 WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61		SETBP_HUMAN (1763-1904): 4.22e-33: 143: 43.15
+	At
		1319861 WDR5A_ARATH (267-425): 1.04e-32: 127: 22.02		ATX1_ARATH (2137-2284): 1.92e-18: 95.1: 37.33