Protein: METH
Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase)

Gene: METH, MTR
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q99707

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0007399 - nervous system development
GO:0008270 - zinc ion binding
GO:0008705 - methionine synthase activity
GO:0009086 - methionine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1016932

AKP13
A-kinase anchor protein 13

3

1

High-throughput

0.667

High

1305770

DOCK5
Dedicator of cytokinesis protein 5

2

0

High-throughput

0.602

High

1305774

MTRR
Methionine synthase reductase

2

0

Small-scale

0.598

High

1303523

CD006
Uncharacterized protein encoded by LINC01587

2

0

High-throughput

0.585

High

1197681

NEK8
Serine/threonine-protein kinase Nek8

2

1

High-throughput

0.558

High

62166

RCCD1
RCC1 domain-containing protein 1

1

1

High-throughput

0.536

High

207099

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.536

High

335304

DYR
Dihydrofolate reductase

1

1

High-throughput

0.536

High

851651

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

863800

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

1305766

TXNIP
Thioredoxin-interacting protein

1

1

High-throughput

0.536

High

790859

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

Small-scale

0.516

High

153164

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

0

High-throughput

0.513

High

328234

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.513

High

374752

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.513

High

515929

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

795564

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.513

High

848457

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

854205

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.513

High

1284780

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1305763

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1305767

SRMS
Tyrosine-protein kinase Srms

1

0

High-throughput

0.513

High

1305773

KLH14
Kelch-like protein 14

1

0

High-throughput

0.513

High

1068644

PLEC
Plectin

1

0

High-throughput

0.493

High

1077331

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.493

High

175506

RA51B
DNA repair protein RAD51 homolog 2

1

1

High-throughput

0.489

High

1223862

AN13A
Ankyrin repeat domain-containing protein 13A

1

1

High-throughput

0.489

High

1241910

ARRD4
Arrestin domain-containing protein 4

1

1

High-throughput

0.489

High

476261

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

1042374

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1146773

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

1204323

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.479

High

1305760

B9D2
B9 domain-containing protein 2

1

1

High-throughput

0.479

High

1305775

ANC2
Anaphase-promoting complex subunit 2

1

3

High-throughput

0.479

High

1305776

B9D1
B9 domain-containing protein 1

1

1

High-throughput

0.479

High

164462

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.458

High

323047

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

348886

RASN
GTPase NRas

1

0

High-throughput

0.458

High

385412

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

430319

PROF1
Profilin-1

1

0

High-throughput

0.458

High

504635

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

636513

DNJB2
DnaJ homolog subfamily B member 2

1

0

High-throughput

0.458

High

740048

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

779979

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

882519

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

921694

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

1035566

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1101245

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1171397

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1234371

WDTC1
WD and tetratricopeptide repeats protein 1

1

0

High-throughput

0.458

High

1305072

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.458

High

1305765

SHRPN
Sharpin

1

0

Small-scale

0.458

High

1305769

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1305771

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1305777

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.458

High

1305778

MMAC
Cyanocobalamin reductase / alkylcobalamin dealkylase

1

0

Small-scale

0.458

High

1169892

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

1170327

INSY2
Inhibitory synaptic factor 2A

2

0

High-throughput

0.328

High

1305761

AFG2B
ATPase family gene 2 protein homolog B

2

0

High-throughput

0.328

High

341458

FA12
Coagulation factor XII

1

0

High-throughput

0.279

Low

794420

GRK6
G protein-coupled receptor kinase 6

1

0

High-throughput

0.279

Low

830781

ARL4D
ADP-ribosylation factor-like protein 4D

1

0

High-throughput

0.279

Low

989713

CDK18
Cyclin-dependent kinase 18

1

0

High-throughput

0.279

Low

1021882

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

1100131

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

1125790

VWA2
von Willebrand factor A domain-containing protein 2

1

0

High-throughput

0.279

Low

1125922

TFDP3
Transcription factor Dp family member 3

1

0

High-throughput

0.279

Low

1128357

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.279

Low

1132253

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.279

Low

1236188

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

1244039

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

0

High-throughput

0.279

Low

1286388

ULK4
Serine/threonine-protein kinase ULK4

1

0

High-throughput

0.279

Low

1300565

PSKH2
Serine/threonine-protein kinase H2

1

0

High-throughput

0.279

Low

1305759

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1305762

TSSK6
Testis-specific serine/threonine-protein kinase 6

1

0

High-throughput

0.279

Low

1305764

LRC27
Leucine-rich repeat-containing protein 27

1

0

High-throughput

0.279

Low

1305772

NRBP2
Nuclear receptor-binding protein 2

1

0

High-throughput

0.279

Low

1305779

EMIL1
EMILIN-1

1

0

High-throughput

0.279

Low

176668

SOX12
Transcription factor SOX-12

1

0

High-throughput

0.269

Low

118417

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

319315

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

553529

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

652061

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

719082

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

721255

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1047533

NFYC
Nuclear transcription factor Y subunit gamma

1

0

High-throughput

0.249

Low

1062190

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1076723

RHOH
Rho-related GTP-binding protein RhoH

1

0

High-throughput

0.249

Low

1148187

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

1152061

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1165891

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1185084

DET1
DET1 homolog

1

0

High-throughput

0.249

Low

1255946

DCA11
DDB1- and CUL4-associated factor 11

1

0

High-throughput

0.249

Low

1272889

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

0

High-throughput

0.249

Low

1289831

KTI12
Protein KTI12 homolog

1

0

Small-scale

0.249

Low

1297185

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.249

Low

1305768

Q9H4D1
Protein kinase

1

0

High-throughput

0.249

Low

1108482

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

1241587

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024