Protein: ARHG6
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)

Gene: ARHG6, ARHGEF6
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q15052

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005911 - cell-cell junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1096438

PAK1
Serine/threonine-protein kinase PAK 1

10

16

High-throughput

0.975

High

1097195

PAK2
Serine/threonine-protein kinase PAK 2

9

16

Small-scale

0.971

High

1121949

ARHG7
Rho guanine nucleotide exchange factor 7

7

15

Small-scale

0.964

High

1122391

GIT2
ARF GTPase-activating protein GIT2

6

20

High-throughput

0.946

High

1140210

GIT1
ARF GTPase-activating protein GIT1

6

20

Small-scale

0.945

High

222084

NCK2
Cytoplasmic protein NCK2

4

19

High-throughput

0.892

High

253953

LPXN
Leupaxin

3

12

High-throughput

0.855

High

988376

RAC1
Ras-related C3 botulinum toxin substrate 1

3

20

Small-scale

0.827

High

878462

PAXI
Paxillin

3

12

High-throughput

0.817

High

1140203

SPN90
NCK-interacting protein with SH3 domain

2

3

High-throughput

0.811

High

594004

NCK1
SH2/SH3 adapter protein NCK1

2

20

High-throughput

0.776

High

1122229

SCRIB
Protein scribble homolog

2

4

Small-scale

0.776

High

1140173

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

3

8

High-throughput

0.765

High

955186

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.754

High

213360

ARHG9
Rho guanine nucleotide exchange factor 9

2

14

High-throughput

0.737

High

167512

TX1B3
Tax1-binding protein 3

1

12

High-throughput

0.691

High

625393

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.691

High

1140209

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

11

High-throughput

0.691

High

1140188

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

1

High-throughput

0.691

High

258600

SH21A
SH2 domain-containing protein 1A

1

20

Small-scale

0.683

High

992182

SKP1
S-phase kinase-associated protein 1

3

2

High-throughput

0.667

High

1053238

Q05BL1
TP53BP2 protein

1

10

High-throughput

0.665

High

1140193

SH3G3
Endophilin-A3

1

19

High-throughput

0.656

High

921537

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

0

High-throughput

0.638

High

1140202

FBX28
F-box only protein 28

4

1

High-throughput

0.630

High

1140200

SYNCI
Syncoilin

2

8

High-throughput

0.628

High

1115514

ASPP2
Apoptosis-stimulating of p53 protein 2

1

11

High-throughput

0.621

High

1140187

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

8

Small-scale

0.621

High

157396

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.618

High

159207

ABLM1
Actin-binding LIM protein 1

1

10

High-throughput

0.618

High

581059

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

787398

TGFR1
TGF-beta receptor type-1

1

5

Small-scale

0.618

High

788926

TGFR2
TGF-beta receptor type-2

1

5

Small-scale

0.618

High

953457

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

1140172

ARHG6
Rho guanine nucleotide exchange factor 6

1

14

Small-scale

0.618

High

1140175

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.618

High

1140178

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

1140179

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1140192

NEB2
Neurabin-2

1

15

High-throughput

0.618

High

269205

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

1090650

TRAF2
TNF receptor-associated factor 2

2

8

High-throughput

0.606

High

1140180

K1C27
Keratin, type I cytoskeletal 27

2

1

High-throughput

0.606

High

1140186

PNMA1
Paraneoplastic antigen Ma1

2

2

High-throughput

0.606

High

1140194

TRI54
Tripartite motif-containing protein 54

2

12

High-throughput

0.606

High

966330

1433G
14-3-3 protein gamma

2

20

High-throughput

0.601

High

1049306

1433F
14-3-3 protein eta

2

20

High-throughput

0.601

High

1140174

RHG44
Rho GTPase-activating protein 44

2

8

High-throughput

0.594

High

427898

ICAM1
Intercellular adhesion molecule 1

2

3

High-throughput

0.574

High

1140201

MED4
Mediator of RNA polymerase II transcription subunit 4

2

2

High-throughput

0.574

High

999353

HBB
Hemoglobin subunit beta

2

2

High-throughput

0.571

High

999639

HBA
Hemoglobin subunit alpha

2

2

High-throughput

0.571

High

1140204

SLAI2
SLAIN motif-containing protein 2

2

1

High-throughput

0.571

High

1007924

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.553

High

1063260

GOGA2
Golgin subfamily A member 2

2

7

High-throughput

0.553

High

601295

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

1140191

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1140198

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

1140176

TM154
Transmembrane protein 154

2

1

High-throughput

0.549

High

716431

PRDX5
Peroxiredoxin-5, mitochondrial

2

0

High-throughput

0.547

High

854657

RAGP1
Ran GTPase-activating protein 1

2

0

High-throughput

0.547

High

261807

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.536

High

1140182

NT5D3
5'-nucleotidase domain-containing protein 3

1

1

High-throughput

0.536

High

1140197

RBM38
RNA-binding protein 38

1

3

High-throughput

0.536

High

63199

VP37C
Vacuolar protein sorting-associated protein 37C

2

2

High-throughput

0.521

High

566677

PDIA4
Protein disulfide-isomerase A4

2

5

High-throughput

0.521

High

833628

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.515

High

732596

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

1105800

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

6

Small-scale

0.512

High

1140207

IKZF3
Zinc finger protein Aiolos

1

0

High-throughput

0.493

High

1140189

GASP2
G-protein coupled receptor-associated sorting protein 2

1

0

High-throughput

0.486

High

452264

PDIA1
Protein disulfide-isomerase

1

6

High-throughput

0.479

High

651332

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.479

High

716559

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

2

High-throughput

0.479

High

842762

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

16

High-throughput

0.479

High

904732

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

1008160

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

Small-scale

0.479

High

1035628

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

1140181

PABP2
Polyadenylate-binding protein 2

1

5

High-throughput

0.479

High

1140195

KLHL4
Kelch-like protein 4

1

6

High-throughput

0.479

High

1140183

NUTM1
NUT family member 1

1

0

High-throughput

0.460

High

720877

KPYR
Pyruvate kinase PKLR

1

0

Small-scale

0.458

High

867145

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

1028206

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High

1005362

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

2

Small-scale

0.457

High

1140190

SPTCS
Spatacsin

1

1

Small-scale

0.457

High

1048516

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.437

High

1140196

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.437

High

1140199

PCX3
Pecanex-like protein 3

1

8

High-throughput

0.437

High

1140185

ARF
Tumor suppressor ARF

1

0

High-throughput

0.426

High

756205

MCM7
DNA replication licensing factor MCM7

1

6

Small-scale

0.407

High

1140208

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.407

High

1140205

RWD2A
RWD domain-containing protein 2A

2

0

High-throughput

0.316

High

1140177

TM108
Transmembrane protein 108

1

0

High-throughput

0.265

Low

1140206

ZN580
Zinc finger protein 580

1

0

High-throughput

0.265

Low

270247

MTG16
Protein CBFA2T3

1

0

High-throughput

0.251

Low

1140184

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

880141

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.249

Low

87460

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025