Protein: CD2AP
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)

Gene: CD2AP
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q9Y5K6

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0001726 - ruffle
GO:0001771 - immunological synapse formation
GO:0001889 - liver development
GO:0002102 - podosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1384318

SH3K1
SH3 domain-containing kinase-binding protein 1

9

20

Small-scale

0.965

High

1165243

RHG44
Rho GTPase-activating protein 44

4

20

High-throughput

0.892

High

988068

GRB2
Growth factor receptor-bound protein 2

3

19

High-throughput

0.875

High

1430109

RGAP1
Rac GTPase-activating protein 1

3

20

High-throughput

0.871

High

1461871

STAP1
Signal-transducing adaptor protein 1

3

2

High-throughput

0.861

High

1491704

CD2AP
CD2-associated protein

3

19

Small-scale

0.853

High

1229264

RHG17
Rho GTPase-activating protein 17

3

20

Small-scale

0.817

High

1408404

SH3G2
Endophilin-A1

2

20

Small-scale

0.800

High

518751

GRAB
Granzyme B

2

2

Small-scale

0.789

High

942982

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

20

Small-scale

0.768

High

1228506

FTM
Protein fantom

2

14

High-throughput

0.759

High

651470

CBL
E3 ubiquitin-protein ligase CBL

12

20

Small-scale

0.759

High

1060706

SOS1
Son of sevenless homolog 1

2

20

Small-scale

0.754

High

1491252

3BP1
SH3 domain-binding protein 1

2

20

High-throughput

0.754

High

440806

FYN
Tyrosine-protein kinase Fyn

2

20

High-throughput

0.743

High

1461575

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

2

20

Small-scale

0.743

High

855830

CRK
Adapter molecule crk

2

20

High-throughput

0.737

High

866887

CAZA2
F-actin-capping protein subunit alpha-2

6

5

High-throughput

0.732

High

445483

CD2
T-cell surface antigen CD2

5

10

Small-scale

0.725

High

1124771

SRC8
Src substrate cortactin

1

20

Small-scale

0.724

High

1357683

BLNK
B-cell linker protein

1

20

Small-scale

0.715

High

1359652

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

20

Small-scale

0.713

High

915234

CAZA1
F-actin-capping protein subunit alpha-1

5

5

Small-scale

0.711

High

508906

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

Small-scale

0.710

High

867560

CAPZB
F-actin-capping protein subunit beta

5

5

Small-scale

0.706

High

1242433

RHGBA
Rho GTPase-activating protein 11A

1

20

High-throughput

0.691

High

1389992

MB12A
Multivesicular body subunit 12A

4

2

Small-scale

0.674

High

1097965

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

Small-scale

0.654

High

1357030

PDC6I
Programmed cell death 6-interacting protein

3

20

Small-scale

0.647

High

1452839

TA2R7
Taste receptor type 2 member 7

3

0

High-throughput

0.638

High

1446023

PODO
Podocin

2

4

Small-scale

0.624

High

187418

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

Small-scale

0.618

High

243414

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.618

High

247476

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

4

High-throughput

0.618

High

362425

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

364092

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

473487

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

728502

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.618

High

772533

IRS1
Insulin receptor substrate 1

1

20

Small-scale

0.618

High

896947

DYN2
Dynamin-2

1

20

Small-scale

0.618

High

1060728

SOS2
Son of sevenless homolog 2

1

20

Small-scale

0.618

High

1324934

RHG18
Rho GTPase-activating protein 18

1

20

High-throughput

0.618

High

1369284

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

1434347

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1447507

ANLN
Anillin

1

8

High-throughput

0.618

High

1458940

ZO2
Tight junction protein 2

1

20

High-throughput

0.618

High

1036028

KIF23
Kinesin-like protein KIF23

2

14

High-throughput

0.611

High

1351654

TCP1L
T-complex protein 10A homolog 1

3

3

High-throughput

0.604

High

1275990

SETX
Probable helicase senataxin

2

0

High-throughput

0.602

High

1280000

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

20

High-throughput

0.590

High

1419877

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

7

High-throughput

0.590

High

862588

YAP1
Transcriptional coactivator YAP1

2

18

Small-scale

0.584

High

1347911

RIN3
Ras and Rab interactor 3

1

20

High-throughput

0.581

High

1235052

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.575

High

914808

RM12
Large ribosomal subunit protein bL12m

2

1

High-throughput

0.574

High

397327

ESR1
Estrogen receptor

2

13

High-throughput

0.571

High

619972

VCAM1
Vascular cell adhesion protein 1

2

10

High-throughput

0.571

High

1328459

S2541
Mitochondrial carrier protein SCaMC-3L

2

6

High-throughput

0.558

High

1060010

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

15

Small-scale

0.545

High

1144235

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.541

High

483282

CLCA
Clathrin light chain A

1

9

High-throughput

0.536

High

651043

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

8

High-throughput

0.536

High

933369

IF5
Eukaryotic translation initiation factor 5

1

1

High-throughput

0.536

High

969103

PRS8
26S proteasome regulatory subunit 8

1

1

High-throughput

0.536

High

998137

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.536

High

1325152

MILK1
MICAL-like protein 1

1

14

High-throughput

0.536

High

1404998

GA2L1
GAS2-like protein 1

1

14

High-throughput

0.536

High

1407506

TS101
Tumor susceptibility gene 101 protein

1

5

Small-scale

0.536

High

1449222

KIF15
Kinesin-like protein KIF15

1

14

High-throughput

0.536

High

1366054

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

20

High-throughput

0.528

High

631043

RAB4A
Ras-related protein Rab-4A

1

7

Small-scale

0.527

High

292789

RENR
Renin receptor

1

0

High-throughput

0.513

High

652609

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

11

High-throughput

0.508

High

993832

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.501

High

822177

PSB10
Proteasome subunit beta type-10

1

2

High-throughput

0.489

High

1258112

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

11

High-throughput

0.489

High

1312705

BAP18
BPTF-associated chromatin complex component 1

1

1

High-throughput

0.489

High

1329745

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

18

High-throughput

0.489

High

1389717

SGF29
SAGA-associated factor 29

1

1

High-throughput

0.489

High

1391325

CERS2
Ceramide synthase 2

1

1

High-throughput

0.489

High

220321

FRS3
Fibroblast growth factor receptor substrate 3

1

16

Small-scale

0.479

High

249937

NPHN
Nephrin

1

11

Small-scale

0.479

High

283159

PSIP1
PC4 and SFRS1-interacting protein

1

4

High-throughput

0.479

High

346564

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

6

High-throughput

0.479

High

365503

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.479

High

386404

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.479

High

419289

H2A1B
Histone H2A type 1-B/E

1

4

High-throughput

0.479

High

538179

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

556444

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

565503

ITA4
Integrin alpha-4

1

3

High-throughput

0.479

High

643166

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.479

High

714553

PML
Protein PML

1

6

High-throughput

0.479

High

730993

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

767387

MERL
Merlin

1

11

High-throughput

0.479

High

791877

SYUA
Alpha-synuclein

1

2

Small-scale

0.479

High

831720

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

863048

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

15

Small-scale

0.479

High

953215

ACTB
Actin, cytoplasmic 1

1

14

High-throughput

0.479

High

967080

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

995921

ACTC
Actin, alpha cardiac muscle 1

1

13

Small-scale

0.479

High

1049954

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1085645

FOXO1
Forkhead box protein O1

1

7

High-throughput

0.479

High

1094666

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

9

High-throughput

0.479

High

1110220

HDAC1
Histone deacetylase 1

1

4

High-throughput

0.479

High

1141115

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

1146897

PCBP1
Poly(rC)-binding protein 1

1

12

Small-scale

0.479

High

1152315

MARE1
Microtubule-associated protein RP/EB family member 1

1

6

Small-scale

0.479

High

1245161

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1256273

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

1350516

BICD2
Protein bicaudal D homolog 2

1

19

High-throughput

0.479

High

1352414

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1363912

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

4

High-throughput

0.479

High

1364737

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1429038

WWTR1
WW domain-containing transcription regulator protein 1

1

15

High-throughput

0.479

High

1433150

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

1459464

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1461779

CBLC
E3 ubiquitin-protein ligase CBL-C

1

20

Small-scale

0.479

High

211234

HXC11
Homeobox protein Hox-C11

1

7

High-throughput

0.464

High

879671

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.464

High

884425

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

1247065

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1253025

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1313575

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

176281

SYNJ2
Synaptojanin-2

1

20

High-throughput

0.457

High

318936

DEND
Dendrin

1

1

High-throughput

0.457

High

1123892

DCTN1
Dynactin subunit 1

1

13

High-throughput

0.457

High

1420193

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

10

High-throughput

0.457

High

1462487

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

17

High-throughput

0.457

High

1273877

MICA3
[F-actin]-monooxygenase MICAL3

1

18

Small-scale

0.445

High

1437095

VP37B
Vacuolar protein sorting-associated protein 37B

1

20

Small-scale

0.445

High

1460913

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

4

Small-scale

0.445

High

1490729

ST38L
Serine/threonine-protein kinase 38-like

1

8

High-throughput

0.445

High

106926

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

247058

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.437

High

522037

H14
Histone H1.4

1

3

High-throughput

0.437

High

590140

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

696981

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

702206

LYOX
Protein-lysine 6-oxidase

1

1

Small-scale

0.437

High

769623

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

971363

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1096884

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

1206589

PRC2B
Protein PRRC2B

1

16

High-throughput

0.437

High

1226565

DCA15
DDB1- and CUL4-associated factor 15

1

3

High-throughput

0.437

High

1277039

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1434424

RNF41
E3 ubiquitin-protein ligase NRDP1

1

18

Small-scale

0.437

High

1446571

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.437

High

1450987

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

7

High-throughput

0.437

High

1461149

RCOR1
REST corepressor 1

1

2

High-throughput

0.437

High

473224

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.417

High

1399288

DACH2
Dachshund homolog 2

2

0

High-throughput

0.328

High

1334378

IN80E
INO80 complex subunit E

2

0

High-throughput

0.313

High

248373

HBP1
HMG box-containing protein 1

1

0

High-throughput

0.265

Low

1449172

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025