HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: MAML1 (Q92585)
Mastermind-like protein 1 (Mam-1)
Gene: MAML1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	15546612, 12391150, 12050117
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2414 Hs			1 1016
+	Hs
		554303 EP300_HUMAN (1-2414): 0: 1113: 100.00		MUC1_HUMAN (33-685): 9.41e-30: 130: 9.34
+	Hs
		998874 EP300_HUMAN (1-2414): 0: 1113: 100.00		MAML2_HUMAN (16-1015): 5.48e-28: 124: 14.45
+	Hs
		998826 EP300_HUMAN (1-2414): 0: 1113: 100.00		SRCAP_HUMAN (63-731): 1.1e-13: 78: 11.10
+	Hs
		998710 EP300_HUMAN (1-2414): 0: 1113: 100.00		MDC1_HUMAN (2-552): 1.48e-10: 67.6: 7.96
+	Hs
		998981 EP300_HUMAN (1-2414): 0: 1113: 100.00		ZN469_HUMAN (85-946): 2.05e-09: 64.2: 8.97
+	Hs
		1199170 PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92		MAML1_HUMAN (1-1016): 2.48e-129: 419: 100.00
+	Hs
		1017367 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		BPTF_HUMAN (342-959): 6.75e-12: 72.5: 14.33
+	Hs
		1057027 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		MDC1_HUMAN (2-552): 1.48e-10: 67.6: 7.96
+	Hs
		554259 MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23		MUC1_HUMAN (33-685): 9.41e-30: 130: 9.34
+	Hs
		631413 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		BPTF_HUMAN (342-959): 6.75e-12: 72.5: 14.33
+	Hs
		1017300 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		BPTF_HUMAN (342-959): 6.75e-12: 72.5: 14.33
+	Hs
		1219797 PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86		ANKH1_HUMAN (156-983): 1.46e-28: 126: 13.05
+	Hs
		631425 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		MDC1_HUMAN (2-552): 1.48e-10: 67.6: 7.96
+	Hs
		1056838 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		MDC1_HUMAN (2-552): 1.48e-10: 67.6: 7.96
+	Hs
		1056876 MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82		MICA3_HUMAN (265-960): 1.4e-23: 110: 11.13
+	Mm
		1351630 PCLO_MOUSE (1988-2414): 9.66e-13: 76.7: 11.24		PCLO_MOUSE (270-1011): 5.28e-22: 105: 9.93
+	Dm
		113976 M9PB30_DROME (5-444): 3.69e-13: 78.3: 7.05		M9PB30_DROME (26-946): 1.07e-16: 88.1: 8.56
+	Hs
		1056827 MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82		MDC1_HUMAN (2-552): 1.48e-10: 67.6: 7.96
+	Hs
		1199209 PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92		CHD7_HUMAN (288-950): 2.44e-12: 73.8: 10.42
+	Hs
		257668 PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86		ANR17_HUMAN (261-987): 1.87e-09: 64.1: 11.08