Protein: CCNT1
Cyclin-T1 (CycT1) (Cyclin-T)

Gene: CCNT1
Organism: Homo sapiens
Interactions: 216
UniProt ID: O60563

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000976 - transcription cis-regulatory region binding
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

251544

CDK9
Cyclin-dependent kinase 9

57

20

Small-scale

0.997

High

251670

AFF4
AF4/FMR2 family member 4

7

2

Small-scale

0.967

High

251568

CDK6
Cyclin-dependent kinase 6

3

20

High-throughput

0.861

High

251546

AFF1
AF4/FMR2 family member 1

5

3

Small-scale

0.823

High

251490

HEXI1
Protein HEXIM1

19

4

Small-scale

0.767

High

251484

BRD4
Bromodomain-containing protein 4

12

15

Small-scale

0.758

High

251592

LARP7
La-related protein 7

9

7

Small-scale

0.751

High

251493

MYC
Myc proto-oncogene protein

6

7

Small-scale

0.730

High

251528

KPCI
Protein kinase C iota type

1

7

Small-scale

0.724

High

251535

KC1D
Casein kinase I isoform delta

1

4

High-throughput

0.691

High

251539

KC1E
Casein kinase I isoform epsilon

1

9

High-throughput

0.691

High

251542

CLK2
Dual specificity protein kinase CLK2

1

20

High-throughput

0.691

High

251543

CLK3
Dual specificity protein kinase CLK3

1

20

High-throughput

0.691

High

251579

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

20

High-throughput

0.691

High

251591

MK06
Mitogen-activated protein kinase 6

1

12

High-throughput

0.691

High

251634

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

20

High-throughput

0.691

High

251656

ELL3
RNA polymerase II elongation factor ELL3

4

5

High-throughput

0.691

High

251533

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

2

High-throughput

0.675

High

251642

HEXI2
Protein HEXIM2

3

4

High-throughput

0.667

High

251494

ESR1
Estrogen receptor

3

19

Small-scale

0.660

High

251530

AF9
Protein AF-9

3

4

Small-scale

0.656

High

251607

MEPCE
7SK snRNA methylphosphate capping enzyme

3

1

High-throughput

0.656

High

251537

CDK8
Cyclin-dependent kinase 8

1

20

Small-scale

0.646

High

251520

PML
Protein PML

2

8

Small-scale

0.634

High

251572

ENL
Protein ENL

2

8

Small-scale

0.628

High

251632

PSPC1
Paraspeckle component 1

2

3

High-throughput

0.628

High

251665

H2AW
Core histone macro-H2A.2

2

3

High-throughput

0.628

High

251510

CEBPB
CCAAT/enhancer-binding protein beta

2

4

Small-scale

0.624

High

251482

CCNT1
Cyclin-T1

1

7

Small-scale

0.621

High

251601

CTR9
RNA polymerase-associated protein CTR9 homolog

2

5

Small-scale

0.618

High

251483

CCNT2
Cyclin-T2

1

7

High-throughput

0.618

High

251488

CDK14
Cyclin-dependent kinase 14

1

20

High-throughput

0.618

High

251498

CDK1
Cyclin-dependent kinase 1

1

20

High-throughput

0.618

High

251514

CD11B
Cyclin-dependent kinase 11B

1

20

High-throughput

0.618

High

251584

CDK10
Cyclin-dependent kinase 10

1

20

High-throughput

0.618

High

251573

KMT2A
Histone-lysine N-methyltransferase 2A

2

6

Small-scale

0.611

High

130321

SPT5H
Transcription elongation factor SPT5

2

4

Small-scale

0.602

High

128653

MEN1
Menin

2

1

High-throughput

0.584

High

251551

ELL
RNA polymerase II elongation factor ELL

2

5

Small-scale

0.584

High

251595

BRDT
Bromodomain testis-specific protein

2

20

Small-scale

0.584

High

251618

SLX4
Structure-specific endonuclease subunit SLX4

2

2

High-throughput

0.584

High

251508

CATE
Cathepsin E

2

1

High-throughput

0.574

High

251525

AHR
Aryl hydrocarbon receptor

1

2

Small-scale

0.573

High

251666

MDFIC
MyoD family inhibitor domain-containing protein

1

1

Small-scale

0.573

High

251580

SNW1
SNW domain-containing protein 1

2

1

Small-scale

0.571

High

251671

NUFP1
FMR1-interacting protein NUFIP1

1

0

Small-scale

0.537

High

137302

ELL2
RNA polymerase II elongation factor ELL2

1

11

High-throughput

0.536

High

209164

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

4

High-throughput

0.536

High

212109

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

High-throughput

0.536

High

217346

E41L2
Band 4.1-like protein 2

1

2

High-throughput

0.536

High

228119

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

2

High-throughput

0.536

High

251485

PR40A
Pre-mRNA-processing factor 40 homolog A

1

7

High-throughput

0.536

High

251487

TOX4
TOX high mobility group box family member 4

1

7

High-throughput

0.536

High

251491

MED26
Mediator of RNA polymerase II transcription subunit 26

1

2

High-throughput

0.536

High

251502

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.536

High

251517

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.536

High

251526

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.536

High

251531

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

251534

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.536

High

251541

RBM25
RNA-binding protein 25

1

1

High-throughput

0.536

High

251545

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.536

High

251550

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.536

High

251554

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

251559

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

4

High-throughput

0.536

High

251570

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

1

High-throughput

0.536

High

251575

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

4

High-throughput

0.536

High

251581

SRC8
Src substrate cortactin

1

4

High-throughput

0.536

High

251586

SF3B4
Splicing factor 3B subunit 4

1

3

High-throughput

0.536

High

251590

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

4

High-throughput

0.536

High

251599

CDC73
Parafibromin

1

1

Small-scale

0.536

High

251600

TAF2
Transcription initiation factor TFIID subunit 2

1

1

High-throughput

0.536

High

251604

WDR82
WD repeat-containing protein 82

1

8

High-throughput

0.536

High

251611

NUFP2
FMR1-interacting protein NUFIP2

1

1

High-throughput

0.536

High

251615

DDX42
ATP-dependent RNA helicase DDX42

1

3

High-throughput

0.536

High

251620

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

4

High-throughput

0.536

High

251627

RB15B
Putative RNA-binding protein 15B

1

6

High-throughput

0.536

High

251630

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

3

High-throughput

0.536

High

251631

ATX2L
Ataxin-2-like protein

1

3

High-throughput

0.536

High

251644

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

2

High-throughput

0.536

High

251652

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.536

High

251658

E41L5
Band 4.1-like protein 5

1

3

High-throughput

0.536

High

251659

DDX21
Nucleolar RNA helicase 2

1

4

High-throughput

0.536

High

251660

DCA13
DDB1- and CUL4-associated factor 13

1

1

High-throughput

0.536

High

251662

SLTM
SAFB-like transcription modulator

1

1

High-throughput

0.536

High

251663

DDX56
Probable ATP-dependent RNA helicase DDX56

1

5

High-throughput

0.536

High

251667

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

1

1

High-throughput

0.536

High

251674

E41L3
Band 4.1-like protein 3

1

2

High-throughput

0.536

High

186671

P73
Tumor protein p73

1

9

Small-scale

0.515

High

251587

TAF7
Transcription initiation factor TFIID subunit 7

1

1

Small-scale

0.515

High

129619

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.513

High

251506

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

251553

FGF12
Fibroblast growth factor 12

1

0

High-throughput

0.513

High

251560

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.513

High

251603

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.513

High

251626

FA98A
Protein FAM98A

1

0

High-throughput

0.513

High

251628

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.513

High

251645

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.513

High

251675

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.513

High

225230

HTSF1
17S U2 SnRNP complex component HTATSF1

1

4

Small-scale

0.501

High

251516

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

Small-scale

0.501

High

251523

T2FA
General transcription factor IIF subunit 1

1

1

Small-scale

0.501

High

251569

PURA
Transcriptional activator protein Pur-alpha

1

3

Small-scale

0.501

High

251593

GRAP1
GRIP1-associated protein 1

1

2

Small-scale

0.501

High

251638

KAT2B
Histone acetyltransferase KAT2B

1

15

Small-scale

0.501

High

251515

TCEA1
Transcription elongation factor A protein 1

1

4

Small-scale

0.500

High

251621

PAF1
RNA polymerase II-associated factor 1 homolog

1

1

Small-scale

0.500

High

251564

RT11
Small ribosomal subunit protein uS11m

1

4

High-throughput

0.489

High

251596

FA76B
Protein FAM76B

1

1

High-throughput

0.489

High

251622

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

1

High-throughput

0.489

High

251640

ARRD3
Arrestin domain-containing protein 3

1

4

High-throughput

0.489

High

251648

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

131608

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

142459

IMA3
Importin subunit alpha-3

1

3

High-throughput

0.479

High

211521

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

2

Small-scale

0.479

High

213348

ARHG9
Rho guanine nucleotide exchange factor 9

1

3

High-throughput

0.479

High

214646

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

1

High-throughput

0.479

High

231075

AIRE
Autoimmune regulator

1

3

Small-scale

0.479

High

240230

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

251486

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

251489

ARHGF
Rho guanine nucleotide exchange factor 15

1

1

High-throughput

0.479

High

251495

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

251496

P53
Cellular tumor antigen p53

1

9

High-throughput

0.479

High

251497

HSPB1
Heat shock protein beta-1

1

5

High-throughput

0.479

High

251501

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.479

High

251503

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

5

High-throughput

0.479

High

251505

ANDR
Androgen receptor

1

19

High-throughput

0.479

High

251507

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

251509

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

251511

DDX5
Probable ATP-dependent RNA helicase DDX5

1

3

High-throughput

0.479

High

251518

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

251522

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

251524

FUS
RNA-binding protein FUS

1

5

High-throughput

0.479

High

251532

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

251536

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

251538

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

Small-scale

0.479

High

251540

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.479

High

251548

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.479

High

251552

MAX
Protein max

1

7

Small-scale

0.479

High

251555

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

251556

RS14
Small ribosomal subunit protein uS11

1

4

High-throughput

0.479

High

251557

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

251558

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

4

High-throughput

0.479

High

251561

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.479

High

251562

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

251563

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.479

High

251566

H33
Histone H3.3

1

2

High-throughput

0.479

High

251571

RL6
Large ribosomal subunit protein eL6

1

1

High-throughput

0.479

High

251576

AKP13
A-kinase anchor protein 13

1

4

High-throughput

0.479

High

251577

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

5

High-throughput

0.479

High

251578

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

251585

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

251588

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.479

High

251589

NCOA2
Nuclear receptor coactivator 2

1

2

Small-scale

0.479

High

251594

RHG29
Rho GTPase-activating protein 29

1

2

High-throughput

0.479

High

251597

RHG21
Rho GTPase-activating protein 21

1

2

High-throughput

0.479

High

251598

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

3

Small-scale

0.479

High

251609

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

3

High-throughput

0.479

High

251610

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

251613

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

251616

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.479

High

251617

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

251629

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

251633

ASB11
Ankyrin repeat and SOCS box protein 11

1

1

High-throughput

0.479

High

251635

ESR2
Estrogen receptor beta

1

19

High-throughput

0.479

High

251636

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

251637

RBP56
TATA-binding protein-associated factor 2N

1

3

High-throughput

0.479

High

251641

RNF31
E3 ubiquitin-protein ligase RNF31

1

8

High-throughput

0.479

High

251646

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.479

High

251650

DOCK9
Dedicator of cytokinesis protein 9

1

2

High-throughput

0.479

High

251651

NSD3
Histone-lysine N-methyltransferase NSD3

1

3

Small-scale

0.479

High

251669

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

251672

VAV3
Guanine nucleotide exchange factor VAV3

1

2

High-throughput

0.479

High

251499

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

251500

PROF1
Profilin-1

1

0

Small-scale

0.458

High

251549

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.458

High

251565

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

251567

DAB2
Disabled homolog 2

1

0

Small-scale

0.458

High

251582

MVP
Major vault protein

1

0

High-throughput

0.458

High

251583

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

251602

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

251624

KDM1B
Lysine-specific histone demethylase 2

1

0

Small-scale

0.458

High

251625

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

251639

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

251649

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

251654

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

251655

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

251664

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

251673

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

251492

PTBP3
Polypyrimidine tract-binding protein 3

1

5

High-throughput

0.445

High

251529

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.445

High

251547

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.445

High

251574

EP300
Histone acetyltransferase p300

1

13

Small-scale

0.445

High

251619

FAM9B
Protein FAM9B

1

1

High-throughput

0.445

High

251643

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.445

High

251512

PEPC
Gastricsin

1

1

Small-scale

0.437

High

251605

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

251608

OTU6A
OTU domain-containing protein 6A

1

2

Small-scale

0.437

High

251653

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

251661

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.437

High

251657

SENP2
Sentrin-specific protease 2

1

0

High-throughput

0.426

High

251612

T150A
Transmembrane protein 150A

3

0

High-throughput

0.347

High

251614

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

0

High-throughput

0.347

High

251676

CCG2
Voltage-dependent calcium channel gamma-2 subunit

3

0

High-throughput

0.347

High

251519

GRN
Progranulin

1

0

Small-scale

0.299

High

162757

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

High-throughput

0.279

Low

251504

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

251513

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.279

Low

251521

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.279

Low

251527

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

251647

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.279

Low

208437

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

Small-scale

0.249

Low

251623

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

62425

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

251606

NCKX5
Sodium/potassium/calcium exchanger 5

1

0

High-throughput

0.232

Low

251668

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025