HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15831486
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 537
+	Hs
		235040 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		235037 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		YES_HUMAN (1-537): 0: 591: 71.61
+	Mm
		250949 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		SRC_MOUSE (1-537): 0: 599: 68.33
+	Hs
		235035 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		LCK_HUMAN (40-535): 0: 551: 57.60
+	Hs
		235031 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56
+	Mm
		250950 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		LYN_MOUSE (1-535): 0: 535: 53.92
+	Hs
		523124 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		SRC_HUMAN (1-537): 0: 598: 68.21
+	Hs
		433460 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		YES_HUMAN (1-537): 0: 591: 71.61
+	Hs
		454844 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		FGR_HUMAN (1-536): 0: 581: 69.82
+	Mm
		250948 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		ABL1_MOUSE (42-537): 4.1e-167: 504: 39.56
+	Hs
		235052 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		TXK_HUMAN (87-527): 1.6e-158: 463: 38.65
+	Hs
		442876 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		HCK_HUMAN (1-535): 0: 548: 56.64
+	Mm
		639441 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		LYN_MOUSE (1-535): 0: 535: 53.92
+	Hs
		433966 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		LYN_HUMAN (1-535): 0: 535: 54.48
+	Hs
		789086 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL2_HUMAN (7-537): 2.06e-170: 515: 38.09
+	Mm
		337623 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		ABL1_MOUSE (42-537): 4.1e-167: 504: 39.56
+	Hs
		337542 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56
+	Mm
		623689 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		TEC_MOUSE (5-529): 5.3e-162: 476: 34.95
+	Hs
		996570 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ITK_HUMAN (4-526): 5.88e-165: 483: 31.90
+	Hs
		789005 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		TEC_HUMAN (5-529): 6.12e-163: 478: 34.89