HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: YES (P07947)
Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
Gene: YES1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 543
+	Hs
		235040 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		SRC_HUMAN (1-543): 0: 601: 74.22
+	Hs
		235036 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		FYN_HUMAN (1-543): 0: 582: 72.16
+	Mm
		250949 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		SRC_MOUSE (1-543): 0: 598: 73.67
+	Hs
		235035 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		LCK_HUMAN (83-541): 0: 540: 60.78
+	Hs
		433460 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		YES_HUMAN (1-543): 0: 617: 100.00
+	Hs
		523124 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		SRC_HUMAN (1-543): 0: 601: 74.22
+	Hs
		235031 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10
+	Mm
		250950 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		LYN_MOUSE (1-541): 1.19e-179: 517: 53.14
+	Hs
		235052 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		TXK_HUMAN (87-532): 3.37e-165: 480: 37.09
+	Mm
		250948 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		ABL1_MOUSE (41-543): 2.47e-161: 490: 39.10
+	Hs
		454844 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		FGR_HUMAN (1-542): 0: 562: 67.10
+	Hs
		442876 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		HCK_HUMAN (1-541): 0: 544: 57.49
+	Mm
		639441 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		LYN_MOUSE (1-541): 1.19e-179: 517: 53.14
+	Hs
		433966 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		LYN_HUMAN (1-541): 3.82e-179: 515: 53.69
+	Hs
		789086 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL2_HUMAN (9-543): 9.27e-166: 503: 37.96
+	Mm
		623689 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		TEC_MOUSE (7-535): 1.17e-168: 493: 33.33
+	Mm
		337623 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		ABL1_MOUSE (41-543): 2.47e-161: 490: 39.10
+	Hs
		337542 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL1_HUMAN (41-543): 5.93e-161: 489: 39.10
+	Hs
		996570 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ITK_HUMAN (7-532): 1.69e-157: 464: 31.54
+	Hs
		789005 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		TEC_HUMAN (7-535): 6.76e-156: 460: 32.96