HitPredict

Interactor 1: DOK2 (O60496)
Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
Gene: DOK2

Interactor 2: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15831486
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 536
+	Mm
		250949 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		SRC_MOUSE (1-536): 0: 650: 98.13
+	Hs
		235037 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		YES_HUMAN (1-536): 0: 604: 73.85
+	Hs
		235036 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		FYN_HUMAN (1-536): 0: 598: 68.39
+	Hs
		235035 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		LCK_HUMAN (75-534): 0: 552: 58.48
+	Hs
		523124 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		SRC_HUMAN (1-536): 0: 651: 100.00
+	Hs
		235031 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00
+	Mm
		250950 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		LYN_MOUSE (1-531): 0: 535: 52.26
+	Hs
		433460 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		YES_HUMAN (1-536): 0: 604: 73.85
+	Hs
		235051 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		CSK_HUMAN (84-525): 2.44e-172: 496: 39.16
+	Hs
		454844 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		FGR_HUMAN (1-535): 0: 583: 65.99
+	Mm
		250948 DOK2_MOUSE (1-412): 4.24e-137: 400: 74.04		ABL1_MOUSE (47-536): 4.29e-169: 509: 40.00
+	Hs
		235052 DOK2_HUMAN (1-412): 4.64e-151: 435: 100.00		TXK_HUMAN (13-526): 7.51e-161: 469: 34.55
+	Hs
		442876 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		HCK_HUMAN (1-531): 0: 569: 55.22
+	Mm
		639441 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		LYN_MOUSE (1-531): 0: 535: 52.26
+	Hs
		433966 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		LYN_HUMAN (1-531): 0: 532: 52.44
+	Mm
		337623 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		ABL1_MOUSE (47-536): 4.29e-169: 509: 40.00
+	Hs
		789086 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL2_HUMAN (11-536): 3.03e-170: 514: 39.03
+	Hs
		337542 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		ABL1_HUMAN (47-536): 5.59e-169: 509: 40.00
+	Mm
		623689 DOK1_MOUSE (3-393): 1.33e-111: 337: 37.12		TEC_MOUSE (88-528): 4.39e-153: 453: 38.22
+	Hs
		789005 DOK1_HUMAN (3-394): 3.4e-108: 328: 35.53		TEC_HUMAN (83-528): 6.43e-155: 458: 37.36