Protein: PEPL
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)

Gene: PEPL, PPL
Organism: Homo sapiens
Interactions: 160
UniProt ID: O60437

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005198 - structural molecule activity
GO:0005200 - structural constituent of cytoskeleton
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

234175

VIME
Vimentin

3

20

Small-scale

0.680

High

234210

TRAF2
TNF receptor-associated factor 2

3

12

High-throughput

0.675

High

234218

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

6

High-throughput

0.667

High

234267

SUSD3
Sushi domain-containing protein 3

3

1

High-throughput

0.667

High

234279

RBM24
RNA-binding protein 24

3

9

High-throughput

0.667

High

234220

RBP1
RalA-binding protein 1

3

11

High-throughput

0.665

High

234193

AKT1
RAC-alpha serine/threonine-protein kinase

2

19

Small-scale

0.649

High

234236

PKHA7
Pleckstrin homology domain-containing family A member 7

3

20

High-throughput

0.647

High

234181

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

3

0

High-throughput

0.646

High

234271

RAB3I
Rab-3A-interacting protein

3

0

High-throughput

0.646

High

234172

FRIH
Ferritin heavy chain

2

1

High-throughput

0.628

High

234247

CCYL1
Cyclin-Y-like protein 1

2

1

High-throughput

0.628

High

234248

FRMD1
FERM domain-containing protein 1

2

20

High-throughput

0.628

High

234269

CDK15
Cyclin-dependent kinase 15

2

19

High-throughput

0.628

High

234165

ANXA9
Annexin A9

2

7

Small-scale

0.621

High

234251

ZSCA1
Zinc finger and SCAN domain-containing protein 1

3

16

High-throughput

0.616

High

234235

K1C39
Keratin, type I cytoskeletal 39

2

20

High-throughput

0.615

High

234232

MYOME
Myomegalin

2

18

High-throughput

0.611

High

234305

DD19B
ATP-dependent RNA helicase DDX19B

2

8

High-throughput

0.611

High

234186

ZSC20
Zinc finger and SCAN domain-containing protein 20

3

5

High-throughput

0.609

High

234291

UD110
UDP-glucuronosyltransferase 1A10

3

2

High-throughput

0.609

High

234188

DESM
Desmin

2

20

High-throughput

0.606

High

234213

IKZF1
DNA-binding protein Ikaros

2

5

High-throughput

0.606

High

234240

K1C25
Keratin, type I cytoskeletal 25

2

16

High-throughput

0.606

High

234289

ARP5
Actin-related protein 5

2

20

High-throughput

0.606

High

234295

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

234197

HD
Huntingtin

2

9

High-throughput

0.596

High

234293

ANLN
Anillin

2

16

High-throughput

0.584

High

234211

RM28
Large ribosomal subunit protein bL28m

2

0

High-throughput

0.580

High

234255

POF1B
Protein POF1B

2

0

High-throughput

0.580

High

234261

UPP
Uracil phosphoribosyltransferase homolog

2

0

High-throughput

0.580

High

234309

SKAP
Small kinetochore-associated protein

2

0

High-throughput

0.580

High

234288

ACAD9
Complex I assembly factor ACAD9, mitochondrial

2

4

High-throughput

0.574

High

234297

TB22B
TBC1 domain family member 22B

2

6

High-throughput

0.574

High

234307

FCF1
rRNA-processing protein FCF1 homolog

2

3

High-throughput

0.574

High

234233

KAZRN
Kazrin

1

2

Small-scale

0.573

High

234183

TRI27
Zinc finger protein RFP

1

8

High-throughput

0.573

High

234244

CE57L
Centrosomal protein CEP57L1

1

1

High-throughput

0.573

High

234308

T22D4
TSC22 domain family protein 4

1

2

High-throughput

0.573

High

234182

CFTR
Cystic fibrosis transmembrane conductance regulator

2

18

High-throughput

0.571

High

234219

KPCD1
Serine/threonine-protein kinase D1

2

18

High-throughput

0.571

High

154537

ZN213
Zinc finger protein 213

2

10

High-throughput

0.553

High

161767

ZN263
Zinc finger protein 263

2

7

High-throughput

0.553

High

234200

ZN165
Zinc finger protein 165

2

6

High-throughput

0.553

High

234226

KCD21
BTB/POZ domain-containing protein KCTD21

2

5

High-throughput

0.553

High

234230

CF141
Uncharacterized protein C6orf141

2

3

High-throughput

0.553

High

234231

HECD3
E3 ubiquitin-protein ligase HECTD3

2

20

High-throughput

0.553

High

234283

PBX4
Pre-B-cell leukemia transcription factor 4

2

6

High-throughput

0.553

High

234286

ZSC16
Zinc finger and SCAN domain-containing protein 16

2

9

High-throughput

0.553

High

234292

ZBT26
Zinc finger and BTB domain-containing protein 26

2

6

High-throughput

0.553

High

216403

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.549

High

130287

BT3A1
Butyrophilin subfamily 3 member A1

1

8

Small-scale

0.543

High

125944

UPK1A
Uroplakin-1a

1

11

High-throughput

0.536

High

182987

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.536

High

234162

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

11

High-throughput

0.536

High

234163

ECI2
Enoyl-CoA delta isomerase 2

1

4

High-throughput

0.536

High

234164

BODG
Gamma-butyrobetaine dioxygenase

1

1

High-throughput

0.536

High

234167

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.536

High

234170

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

20

High-throughput

0.536

High

234171

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

High-throughput

0.536

High

234178

ADT3
ADP/ATP translocase 3

1

2

High-throughput

0.536

High

234185

FOSL1
Fos-related antigen 1

1

1

High-throughput

0.536

High

234187

AATC
Aspartate aminotransferase, cytoplasmic

1

4

High-throughput

0.536

High

234191

ITPI2
Protein ITPRID2

1

2

High-throughput

0.536

High

234194

CCR1
C-C chemokine receptor type 1

1

8

High-throughput

0.536

High

234199

PTSS1
Phosphatidylserine synthase 1

1

3

High-throughput

0.536

High

234202

STX17
Syntaxin-17

1

3

High-throughput

0.536

High

234205

SSBP2
Single-stranded DNA-binding protein 2

1

4

High-throughput

0.536

High

234206

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.536

High

234207

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

1

High-throughput

0.536

High

234208

HSF2
Heat shock factor protein 2

1

4

High-throughput

0.536

High

234209

AHNK
Neuroblast differentiation-associated protein AHNAK

1

9

High-throughput

0.536

High

234214

CUL1
Cullin-1

1

16

High-throughput

0.536

High

234216

ITPR2
Inositol 1,4,5-trisphosphate receptor type 2

1

10

High-throughput

0.536

High

234217

ITPR3
Inositol 1,4,5-trisphosphate receptor type 3

1

10

High-throughput

0.536

High

234222

STK11
Serine/threonine-protein kinase STK11

1

5

High-throughput

0.536

High

234225

MA7D1
MAP7 domain-containing protein 1

1

17

High-throughput

0.536

High

234250

FNDC5
Fibronectin type III domain-containing protein 5

1

5

High-throughput

0.536

High

234259

PIGT
GPI transamidase component PIG-T

1

1

High-throughput

0.536

High

234260

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

2

High-throughput

0.536

High

234264

NEUL4
Neuralized-like protein 4

1

4

High-throughput

0.536

High

234265

CLMN
Calmin

1

19

High-throughput

0.536

High

234273

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.536

High

234276

PXL2A
Peroxiredoxin-like 2A

1

1

High-throughput

0.536

High

234280

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

19

High-throughput

0.536

High

234281

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.536

High

234284

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

20

High-throughput

0.536

High

234287

SYNCI
Syncoilin

1

20

High-throughput

0.536

High

234294

MBNL1
Muscleblind-like protein 1

1

3

High-throughput

0.536

High

234299

KLH11
Kelch-like protein 11

1

5

High-throughput

0.536

High

234302

MTUS1
Microtubule-associated tumor suppressor 1

1

18

High-throughput

0.536

High

234306

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.536

High

234311

RN115
E3 ubiquitin-protein ligase RNF115

1

6

High-throughput

0.536

High

234312

UBP16
Ubiquitin carboxyl-terminal hydrolase 16

1

20

High-throughput

0.536

High

234174

K2C8
Keratin, type II cytoskeletal 8

1

10

Small-scale

0.527

High

234201

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

High-throughput

0.515

High

234189

SPR1B
Cornifin-B

1

0

High-throughput

0.513

High

234274

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.513

High

234296

TNR19
Tumor necrosis factor receptor superfamily member 19

1

0

High-throughput

0.513

High

234179

SKIL
Ski-like protein

1

3

High-throughput

0.508

High

234258

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

19

High-throughput

0.508

High

234177

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.501

High

234204

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

9

Small-scale

0.501

High

234166

OR2A4
Olfactory receptor 2A4

1

4

High-throughput

0.489

High

234203

DSCR6
Protein ripply3

1

1

High-throughput

0.489

High

234224

CR021
UPF0711 protein C18orf21

1

3

High-throughput

0.489

High

234227

FNDC1
Fibronectin type III domain-containing protein 1

1

14

High-throughput

0.489

High

234242

BPHL
Valacyclovir hydrolase

1

1

High-throughput

0.489

High

234243

ZC3C1
Zinc finger C3HC-type protein 1

1

3

High-throughput

0.489

High

234262

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

234263

SGF29
SAGA-associated factor 29

1

3

High-throughput

0.489

High

234266

F167A
Protein FAM167A

1

1

High-throughput

0.489

High

234268

F227B
Protein FAM227B

1

1

High-throughput

0.489

High

234270

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.489

High

234277

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

234290

COE2
Transcription factor COE2

1

1

High-throughput

0.489

High

234301

PHF11
PHD finger protein 11

1

8

High-throughput

0.489

High

234303

COR1C
Coronin-1C

1

20

High-throughput

0.489

High

234221

ITSN1
Intersectin-1

1

20

High-throughput

0.481

High

234304

COHA1
Collagen alpha-1(XVII) chain

1

1

Small-scale

0.481

High

234176

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

10

High-throughput

0.479

High

234180

CADH1
Cadherin-1

1

13

High-throughput

0.479

High

234184

EZRI
Ezrin

1

20

Small-scale

0.479

High

234190

CBL
E3 ubiquitin-protein ligase CBL

1

12

High-throughput

0.479

High

234196

TRI23
E3 ubiquitin-protein ligase TRIM23

1

10

High-throughput

0.479

High

234198

SOX2
Transcription factor SOX-2

1

18

High-throughput

0.479

High

234212

BT1A1
Butyrophilin subfamily 1 member A1

1

8

Small-scale

0.479

High

234215

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.479

High

234223

RBBP7
Histone-binding protein RBBP7

1

20

High-throughput

0.479

High

234234

RNF43
E3 ubiquitin-protein ligase RNF43

1

13

High-throughput

0.479

High

234245

SYNPO
Synaptopodin

1

19

High-throughput

0.479

High

234246

WDTC1
WD and tetratricopeptide repeats protein 1

1

20

High-throughput

0.479

High

234249

NKAI3
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

1

3

High-throughput

0.479

High

234252

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

234257

EVPL
Envoplakin

1

19

Small-scale

0.479

High

234275

FYCO1
FYVE and coiled-coil domain-containing protein 1

1

18

High-throughput

0.479

High

234278

RBM4
RNA-binding protein 4

1

8

High-throughput

0.479

High

234282

FACD2
Fanconi anemia group D2 protein

1

16

High-throughput

0.479

High

234285

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

234298

DCA13
DDB1- and CUL4-associated factor 13

1

17

High-throughput

0.479

High

234300

WRP73
WD repeat-containing protein WRAP73

1

20

High-throughput

0.479

High

234310

LOXL2
Lysyl oxidase homolog 2

1

8

High-throughput

0.479

High

234168

LETM1
Mitochondrial proton/calcium exchanger protein

1

1

High-throughput

0.470

High

234253

PPHLN
Periphilin-1

1

0

Small-scale

0.460

High

234228

DCA17
DDB1- and CUL4-associated factor 17

1

0

High-throughput

0.458

High

131180

BIN1
Myc box-dependent-interacting protein 1

1

13

High-throughput

0.457

High

234192

BKRB2
B2 bradykinin receptor

1

8

Small-scale

0.457

High

47333

A0A6Q8PFP9
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein

1

3

High-throughput

0.445

High

234195

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.445

High

234169

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.437

High

234173

MYCN
N-myc proto-oncogene protein

1

17

High-throughput

0.437

High

234229

DCA10
DDB1- and CUL4-associated factor 10

1

20

High-throughput

0.437

High

234241

WDR5B
WD repeat-containing protein 5B

1

20

High-throughput

0.437

High

234254

DCA11
DDB1- and CUL4-associated factor 11

1

16

High-throughput

0.437

High

234256

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

234272

INT14
Integrator complex subunit 14

1

2

High-throughput

0.437

High

234313

STYL1
Serine/threonine/tyrosine-interacting-like protein 1

1

10

High-throughput

0.437

High

234238

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

2

High-throughput

0.407

High

234237

ZN474
Zinc finger protein 474

2

0

High-throughput

0.316

High

234239

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024