Protein: LMBL3
Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1)

Gene: LMBL3, L3MBTL3
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q96JM7

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1247619

SAMD1
Sterile alpha motif domain-containing protein 1

5

8

High-throughput

0.936

High

1395239

LMBL3
Lethal(3)malignant brain tumor-like protein 3

5

17

High-throughput

0.923

High

930778

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

4

2

High-throughput

0.904

High

853841

MK09
Mitogen-activated protein kinase 9

3

3

High-throughput

0.871

High

1218282

SMBT2
Scm-like with four MBT domains protein 2

3

18

High-throughput

0.843

High

1312482

PHC2
Polyhomeotic-like protein 2

2

19

High-throughput

0.826

High

1219226

SAM13
Sterile alpha motif domain-containing protein 13

4

18

High-throughput

0.813

High

1332329

LMBL4
Lethal(3)malignant brain tumor-like protein 4

2

17

High-throughput

0.811

High

1395259

SMBT1
Scm-like with four MBT domains protein 1

2

17

High-throughput

0.811

High

1095438

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

2

High-throughput

0.740

High

1119771

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

3

High-throughput

0.700

High

691824

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.698

High

246866

KDM1A
Lysine-specific histone demethylase 1A

4

13

High-throughput

0.683

High

1118960

BYST
Bystin

3

1

High-throughput

0.675

High

1136839

MO4L2
Mortality factor 4-like protein 2

3

4

High-throughput

0.675

High

1395240

PKHF1
Pleckstrin homology domain-containing family F member 1

3

2

High-throughput

0.675

High

1395250

PKHF2
Pleckstrin homology domain-containing family F member 2

3

2

High-throughput

0.675

High

1395257

MO4L1
Mortality factor 4-like protein 1

3

4

High-throughput

0.675

High

1332010

BANP
Protein BANP

3

1

High-throughput

0.667

High

938128

ANM2
Protein arginine N-methyltransferase 2

3

2

High-throughput

0.667

High

1271202

DPPA4
Developmental pluripotency-associated protein 4

3

1

High-throughput

0.667

High

269346

HSF2B
Heat shock factor 2-binding protein

3

3

High-throughput

0.665

High

1384407

PF21A
PHD finger protein 21A

3

14

High-throughput

0.653

High

1364853

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

4

5

High-throughput

0.623

High

1231778

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

3

1

High-throughput

0.616

High

1054766

SUH
Recombining binding protein suppressor of hairless

2

6

High-throughput

0.611

High

783739

ZNF76
Zinc finger protein 76

2

2

High-throughput

0.606

High

935603

MFAP1
Microfibrillar-associated protein 1

2

1

High-throughput

0.606

High

994339

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

3

High-throughput

0.606

High

1160986

NRF1
Nuclear respiratory factor 1

2

1

High-throughput

0.606

High

1287250

TBCD1
TBC1 domain family member 1

2

2

High-throughput

0.606

High

1395249

DEFI6
Differentially expressed in FDCP 6 homolog

2

2

High-throughput

0.606

High

1395262

SUFU
Suppressor of fused homolog

2

2

High-throughput

0.606

High

1029138

E2F1
Transcription factor E2F1

2

13

Small-scale

0.601

High

685049

DNMT1
DNA

1

2

Small-scale

0.597

High

1209522

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

Small-scale

0.589

High

981013

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.584

High

1307700

CRLF3
Cytokine receptor-like factor 3

2

0

High-throughput

0.580

High

1331082

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

0

High-throughput

0.580

High

1392842

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

567054

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

2

2

High-throughput

0.574

High

533303

THA
Thyroid hormone receptor alpha

1

11

High-throughput

0.573

High

659281

SP100
Nuclear autoantigen Sp-100

1

7

High-throughput

0.573

High

983687

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.573

High

998686

H31
Histone H3.1

2

20

Small-scale

0.563

High

1161362

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.561

High

1395133

DCAF5
DDB1- and CUL4-associated factor 5

1

6

Small-scale

0.554

High

322753

RHBT3
Rho-related BTB domain-containing protein 3

2

5

High-throughput

0.553

High

353730

DRC4
Dynein regulatory complex subunit 4

2

1

High-throughput

0.553

High

965502

LMO4
LIM domain transcription factor LMO4

2

8

High-throughput

0.553

High

1198270

FND3B
Fibronectin type III domain-containing protein 3B

2

1

High-throughput

0.553

High

1208320

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

2

2

High-throughput

0.553

High

1225047

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

10

High-throughput

0.553

High

1395264

T3JAM
TRAF3-interacting JNK-activating modulator

2

3

High-throughput

0.553

High

574424

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.549

High

1395263

OAZ3
Ornithine decarboxylase antizyme 3

1

0

High-throughput

0.549

High

1395267

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

0

High-throughput

0.549

High

900462

FXR2
RNA-binding protein FXR2

1

7

High-throughput

0.541

High

1395247

ZCPW1
Zinc finger CW-type PWWP domain protein 1

1

2

High-throughput

0.541

High

74570

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

3

High-throughput

0.536

High

173235

XPO1
Exportin-1

1

3

High-throughput

0.536

High

542618

TOP2A
DNA topoisomerase 2-alpha

1

2

High-throughput

0.536

High

977564

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

3

High-throughput

0.536

High

1109989

HDAC1
Histone deacetylase 1

1

14

High-throughput

0.536

High

1157871

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.536

High

1163138

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1368053

HDAC2
Histone deacetylase 2

1

14

High-throughput

0.536

High

1395242

TBA1C
Tubulin alpha-1C chain

1

6

High-throughput

0.536

High

1395246

SKI8
Superkiller complex protein 8

1

3

High-throughput

0.536

High

872637

SOX2
Transcription factor SOX-2

1

7

Small-scale

0.527

High

1395252

ASB6
Ankyrin repeat and SOCS box protein 6

1

2

High-throughput

0.523

High

107815

SUMO5
Small ubiquitin-related modifier 5

1

5

High-throughput

0.515

High

488535

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

1

High-throughput

0.515

High

988613

RAC1
Ras-related C3 botulinum toxin substrate 1

1

1

High-throughput

0.515

High

1395254

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.513

High

1328752

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

1

High-throughput

0.494

High

361333

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

791633

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

843873

HD
Huntingtin

1

0

High-throughput

0.493

High

927492

ATX1
Ataxin-1

1

0

High-throughput

0.493

High

963354

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.493

High

1096167

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

683749

PTX3
Pentraxin-related protein PTX3

1

2

High-throughput

0.489

High

706264

S10A2
Protein S100-A2

1

6

High-throughput

0.489

High

1395248

CPVL
Probable serine carboxypeptidase CPVL

1

1

High-throughput

0.489

High

143463

E2F3
Transcription factor E2F3

1

13

Small-scale

0.479

High

254409

CC14B
Dual specificity protein phosphatase CDC14B

1

1

High-throughput

0.479

High

282766

E2F6
Transcription factor E2F6

1

13

Small-scale

0.479

High

339826

KLF8
Krueppel-like factor 8

1

16

High-throughput

0.479

High

372857

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

589425

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

675629

TYY1
Transcriptional repressor protein YY1

1

10

High-throughput

0.479

High

696228

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

714356

PML
Protein PML

1

4

High-throughput

0.479

High

764966

CTNB1
Catenin beta-1

1

3

High-throughput

0.479

High

768907

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

776111

SOX5
Transcription factor SOX-5

1

8

High-throughput

0.479

High

834031

HNF4A
Hepatocyte nuclear factor 4-alpha

1

12

High-throughput

0.479

High

883658

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

887125

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.479

High

895777

LHX2
LIM/homeobox protein Lhx2

1

7

High-throughput

0.479

High

980148

H4
Histone H4

1

11

High-throughput

0.479

High

995200

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

1037880

HEN1
Helix-loop-helix protein 1

1

2

High-throughput

0.479

High

1045647

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1096790

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

1114009

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1124151

E2F2
Transcription factor E2F2

1

13

Small-scale

0.479

High

1133605

NFIX
Nuclear factor 1 X-type

1

12

High-throughput

0.479

High

1137459

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

1152725

ELF2
ETS-related transcription factor Elf-2

1

12

High-throughput

0.479

High

1155664

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

1156818

E2F4
Transcription factor E2F4

1

13

Small-scale

0.479

High

1289272

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

2

High-throughput

0.479

High

1313339

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

1395241

FEV
Protein FEV

1

11

High-throughput

0.479

High

1395245

KLF16
Krueppel-like factor 16

1

17

High-throughput

0.479

High

1395255

RCOR3
REST corepressor 3

1

16

High-throughput

0.479

High

1395258

ZMYM2
Zinc finger MYM-type protein 2

1

3

High-throughput

0.479

High

1395260

RCOR1
REST corepressor 1

1

16

High-throughput

0.479

High

1395266

KLF12
Krueppel-like factor 12

1

16

High-throughput

0.479

High

1324818

Q8N381
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

5

High-throughput

0.470

High

685310

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.458

High

703187

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

800048

COIL
Coilin

1

0

High-throughput

0.458

High

1395265

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

3475

A0A0S2Z5G4
Protein BANP

1

1

High-throughput

0.457

High

3595

A0A0S2Z6A9
Zinc finger CW type with PWWP domain 1 isoform 6

1

1

High-throughput

0.457

High

1395253

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

1395256

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.437

High

1395261

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

617457

DNLI1
DNA ligase 1

1

1

Small-scale

0.408

High

1395251

NGB
Neuroglobin

3

0

High-throughput

0.352

High

251949

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

2

0

High-throughput

0.316

High

1338798

FAD1
FAD synthase

2

0

High-throughput

0.316

High

1395244

C1QT4
Complement C1q tumor necrosis factor-related protein 4

2

0

High-throughput

0.316

High

615285

CNRG
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

1

0

High-throughput

0.299

High

1214461

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

1

0

High-throughput

0.282

High

1395268

BACE2
Beta-secretase 2

1

0

High-throughput

0.279

Low

47397

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

728815

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.268

Low

1123762

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.268

Low

1395243

PLVAP
Plasmalemma vesicle-associated protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025