Protein: BHE40
Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein)

Gene: BHE40, BHLHE40
Organism: Homo sapiens
Interactions: 135
UniProt ID: O14503

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154917

BHE40
Class E basic helix-loop-helix protein 40

2

19

High-throughput

0.785

High

154927

VENTX
Homeobox protein VENTX

2

8

High-throughput

0.783

High

154962

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.783

High

154980

LASP1
LIM and SH3 domain protein 1

2

1

High-throughput

0.783

High

154986

ZFHX3
Zinc finger homeobox protein 3

2

2

High-throughput

0.783

High

155008

LMO3
LIM domain only protein 3

2

4

High-throughput

0.783

High

154934

TFE2
Transcription factor E2-alpha

1

8

Small-scale

0.713

High

155042

FBW1A
F-box/WD repeat-containing protein 1A

4

7

Small-scale

0.703

High

155038

ZHX1
Zinc fingers and homeoboxes protein 1

1

1

High-throughput

0.698

High

154924

RHBT3
Rho-related BTB domain-containing protein 3

4

4

High-throughput

0.698

High

155006

SMYD1
Histone-lysine N-methyltransferase SMYD1

5

0

High-throughput

0.691

High

154968

TLE5
TLE family member 5

3

20

High-throughput

0.675

High

155044

MAGD1
Melanoma-associated antigen D1

3

2

High-throughput

0.675

High

155037

FBW1B
F-box/WD repeat-containing protein 11

3

7

Small-scale

0.674

High

155033

RFOX1
RNA binding protein fox-1 homolog 1

3

4

High-throughput

0.654

High

154932

MYOD1
Myoblast determination protein 1

1

13

Small-scale

0.647

High

155026

NAA50
N-alpha-acetyltransferase 50

3

0

High-throughput

0.646

High

154928

P53
Cellular tumor antigen p53

2

2

Small-scale

0.628

High

154988

SNAT
Serotonin N-acetyltransferase

2

0

High-throughput

0.626

High

155025

BHE41
Class E basic helix-loop-helix protein 41

1

19

Small-scale

0.618

High

154951

ATX1
Ataxin-1

2

2

High-throughput

0.606

High

154982

DAZP2
DAZ-associated protein 2

2

1

High-throughput

0.606

High

154997

RBPS2
RNA-binding protein with multiple splicing 2

2

3

High-throughput

0.606

High

155013

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

3

High-throughput

0.606

High

155015

TET5B
Terminal nucleotidyltransferase 5B

2

2

High-throughput

0.606

High

155043

ARIP4
Helicase ARIP4

2

1

High-throughput

0.606

High

154975

HDAC1
Histone deacetylase 1

2

6

Small-scale

0.602

High

154938

RXRA
Retinoic acid receptor RXR-alpha

2

3

Small-scale

0.601

High

155023

NPAS2
Neuronal PAS domain-containing protein 2

1

7

High-throughput

0.590

High

154958

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.586

High

154948

WHR1
Winged helix repair factor 1

2

1

High-throughput

0.584

High

154918

PHF1
PHD finger protein 1

2

0

High-throughput

0.580

High

154936

WT1
Wilms tumor protein

2

0

High-throughput

0.580

High

154967

CREM
cAMP-responsive element modulator

2

0

High-throughput

0.580

High

154977

BYST
Bystin

2

0

High-throughput

0.580

High

155001

FA83A
Protein FAM83A

2

0

High-throughput

0.580

High

155009

SMAP2
Stromal membrane-associated protein 2

2

0

High-throughput

0.580

High

155018

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

155022

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

155031

NEK6
Serine/threonine-protein kinase Nek6

2

0

High-throughput

0.580

High

154920

SOX15
Transcription factor SOX-15

1

2

High-throughput

0.573

High

154921

DAB1
Disabled homolog 1

1

1

High-throughput

0.573

High

154974

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.573

High

155000

RBM23
Probable RNA-binding protein 23

1

1

High-throughput

0.573

High

155014

RBPMS
RNA-binding protein with multiple splicing

1

3

High-throughput

0.573

High

154976

AAMP
Angio-associated migratory cell protein

2

3

High-throughput

0.559

High

154933

ZEP1
Zinc finger protein 40

2

0

High-throughput

0.559

High

85462

B7ZLI8
Serine/threonine kinase 19

2

1

High-throughput

0.558

High

154925

MTCL2
Microtubule cross-linking factor 2

2

3

High-throughput

0.553

High

154966

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

2

2

High-throughput

0.553

High

154990

KRA61
Keratin-associated protein 6-1

2

3

High-throughput

0.553

High

154991

KRA62
Keratin-associated protein 6-2

2

5

High-throughput

0.553

High

155004

KRA81
Keratin-associated protein 8-1

2

1

High-throughput

0.553

High

155005

KRA13
Keratin-associated protein 1-3

2

3

High-throughput

0.553

High

154923

CCNK
Cyclin-K

1

0

High-throughput

0.549

High

154978

TOB2
Protein Tob2

1

0

High-throughput

0.549

High

154929

ENOA
Alpha-enolase

1

1

High-throughput

0.541

High

154930

VIME
Vimentin

1

1

High-throughput

0.541

High

154940

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.541

High

154971

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.541

High

154983

SETB1
Histone-lysine N-methyltransferase SETDB1

1

1

High-throughput

0.541

High

155032

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.541

High

154957

SKP1
S-phase kinase-associated protein 1

1

3

High-throughput

0.536

High

154999

LARP4
La-related protein 4

1

1

High-throughput

0.523

High

155017

PKHB2
Pleckstrin homology domain-containing family B member 2

1

2

High-throughput

0.523

High

155029

RHOJ
Rho-related GTP-binding protein RhoJ

1

8

High-throughput

0.523

High

154949

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

154952

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.518

High

154972

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.518

High

155027

TOLIP
Toll-interacting protein

1

0

High-throughput

0.518

High

155021

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.501

High

155007

GMCL2
Germ cell-less protein-like 2

1

0

High-throughput

0.493

High

155010

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

2

High-throughput

0.481

High

155020

TET5A
Terminal nucleotidyltransferase 5A

1

2

High-throughput

0.481

High

155035

TBA8
Tubulin alpha-8 chain

1

6

High-throughput

0.481

High

155045

NUMBL
Numb-like protein

1

1

High-throughput

0.481

High

154926

SC31A
Protein transport protein Sec31A

1

3

Small-scale

0.479

High

154944

FUS
RNA-binding protein FUS

1

3

Small-scale

0.479

High

154946

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.479

High

154947

GATA4
Transcription factor GATA-4

1

3

Small-scale

0.479

High

154955

H4
Histone H4

1

2

High-throughput

0.479

High

154956

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

Small-scale

0.479

High

154965

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

154973

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

154994

TAF3
Transcription initiation factor TFIID subunit 3

1

2

Small-scale

0.479

High

155030

EMAL4
Echinoderm microtubule-associated protein-like 4

1

2

Small-scale

0.479

High

155036

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

Small-scale

0.479

High

155040

PRP19
Pre-mRNA-processing factor 19

1

3

Small-scale

0.479

High

155041

COR2B
Coronin-2B

1

5

Small-scale

0.479

High

91675

C9JG97
Angio-associated migratory cell protein

1

3

High-throughput

0.470

High

154963

PR20D
Proline-rich protein 20D

1

1

High-throughput

0.470

High

154941

PML
Protein PML

1

0

High-throughput

0.458

High

155012

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.458

High

154937

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.457

High

154942

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.457

High

154943

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

2

High-throughput

0.457

High

154945

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.457

High

154950

RORG
Nuclear receptor ROR-gamma

1

19

High-throughput

0.457

High

154953

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

High-throughput

0.457

High

154954

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

5

High-throughput

0.457

High

154959

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

4

High-throughput

0.457

High

154960

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.457

High

154961

CSK21
Casein kinase II subunit alpha

1

14

High-throughput

0.457

High

154979

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

2

High-throughput

0.457

High

154981

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

19

High-throughput

0.457

High

154984

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.457

High

154987

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

2

High-throughput

0.457

High

154989

NFIL3
Nuclear factor interleukin-3-regulated protein

1

6

High-throughput

0.457

High

155011

RORB
Nuclear receptor ROR-beta

1

10

High-throughput

0.457

High

155028

FXL15
F-box/LRR-repeat protein 15

1

2

High-throughput

0.457

High

155046

X5D7T5
RNA binding protein fox-1 homolog

1

4

High-throughput

0.457

High

155047

X5DP44
RNA binding protein fox-1 homolog

1

4

High-throughput

0.457

High

154964

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.439

High

155016

APH1A
Gamma-secretase subunit APH-1A

1

1

High-throughput

0.439

High

154985

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.438

High

154919

BUB3
Mitotic checkpoint protein BUB3

1

3

Small-scale

0.437

High

155039

COR1C
Coronin-1C

1

4

Small-scale

0.437

High

154970

VAC14
Protein VAC14 homolog

3

0

High-throughput

0.352

High

154931

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.327

High

154992

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.316

High

154993

KR197
Keratin-associated protein 19-7

2

0

High-throughput

0.316

High

154998

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

155002

GPSM1
G-protein-signaling modulator 1

2

0

High-throughput

0.316

High

155003

KR191
Keratin-associated protein 19-1

2

0

High-throughput

0.316

High

155019

KLD7B
Kelch domain-containing protein 7B

2

0

High-throughput

0.316

High

50048

KR231
Keratin-associated protein 23-1

1

0

High-throughput

0.299

High

154935

CNRG
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

1

0

High-throughput

0.299

High

154995

TTC23
Tetratricopeptide repeat protein 23

1

0

High-throughput

0.299

High

154996

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

1

0

High-throughput

0.299

High

155024

NOC4L
Nucleolar complex protein 4 homolog

1

0

High-throughput

0.299

High

155034

TXN4B
Thioredoxin-like protein 4B

1

0

High-throughput

0.299

High

154939

FBLN1
Fibulin-1

1

0

High-throughput

0.282

High

154969

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.268

Low

154922

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025