Protein: ARBK1
Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)

Gene: ARBK1, GRK2
Organism: Homo sapiens
Interactions: 81
UniProt ID: P25098

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0002026 - regulation of the force of heart contraction
GO:0002029 - desensitization of G protein-coupled receptor signaling pathway
GO:0003108 - negative regulation of the force of heart contraction by chemical signal
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

669115

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

4

8

Small-scale

0.908

High

669109

ARBK2
G protein-coupled receptor kinase 3

3

16

High-throughput

0.861

High

458283

ADRB2
Beta-2 adrenergic receptor

3

10

Small-scale

0.840

High

436611

KPCB
Protein kinase C beta type

2

19

Small-scale

0.834

High

669153

GIT1
ARF GTPase-activating protein GIT1

3

9

Small-scale

0.827

High

669144

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

3

High-throughput

0.811

High

362792

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.754

High

557103

SRC
Proto-oncogene tyrosine-protein kinase Src

2

16

Small-scale

0.754

High

669152

CSEN
Calsenilin

1

7

Small-scale

0.747

High

410630

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.743

High

669107

GNA15
Guanine nucleotide-binding protein subunit alpha-15

1

8

Small-scale

0.724

High

669121

MDM2
E3 ubiquitin-protein ligase Mdm2

5

5

Small-scale

0.706

High

669104

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.698

High

669130

RGRF1
Ras-specific guanine nucleotide-releasing factor 1

1

4

High-throughput

0.698

High

669101

IKBA
NF-kappa-B inhibitor alpha

1

13

Small-scale

0.692

High

461166

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

468088

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.691

High

638390

FPR1
fMet-Leu-Phe receptor

1

13

Small-scale

0.691

High

669112

FRK
Tyrosine-protein kinase FRK

1

17

High-throughput

0.691

High

669133

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

16

High-throughput

0.691

High

507542

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.665

High

564801

NCAM1
Neural cell adhesion molecule 1

1

2

High-throughput

0.665

High

641485

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.665

High

669113

KC1D
Casein kinase I isoform delta

1

4

High-throughput

0.665

High

669119

CSK2B
Casein kinase II subunit beta

1

8

High-throughput

0.656

High

669129

PTC1
Protein patched homolog 1

3

1

Small-scale

0.656

High

465750

OPSD
Rhodopsin

1

13

Small-scale

0.647

High

663511

FSHR
Follicle-stimulating hormone receptor

1

16

Small-scale

0.647

High

669146

PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

1

2

Small-scale

0.647

High

669117

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

3

9

Small-scale

0.646

High

669124

ACACA
Acetyl-CoA carboxylase 1

2

9

High-throughput

0.628

High

669149

TBC14
TBC1 domain family member 14

2

1

High-throughput

0.628

High

209201

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

7

High-throughput

0.618

High

484059

PGFRB
Platelet-derived growth factor receptor beta

1

15

Small-scale

0.618

High

572410

DRD2
D(2) dopamine receptor

1

9

Small-scale

0.618

High

665305

EDNRB
Endothelin receptor type B

1

11

Small-scale

0.618

High

669100

ARBK1
Beta-adrenergic receptor kinase 1

1

15

High-throughput

0.618

High

669106

AGTR1
Type-1 angiotensin II receptor

1

13

Small-scale

0.618

High

669116

CCR4
C-C chemokine receptor type 4

1

12

Small-scale

0.618

High

669126

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

13

Small-scale

0.618

High

669128

SQSTM
Sequestosome-1

1

3

High-throughput

0.618

High

669131

GIT2
ARF GTPase-activating protein GIT2

1

8

Small-scale

0.618

High

669132

CDC37
Hsp90 co-chaperone Cdc37

1

16

High-throughput

0.618

High

669137

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

669138

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.618

High

669118

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

2

9

Small-scale

0.595

High

669150

HDAC6
Protein deacetylase HDAC6

1

11

Small-scale

0.578

High

669134

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.575

High

597340

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

10

Small-scale

0.561

High

669111

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

12

Small-scale

0.561

High

669110

SYUA
Alpha-synuclein

2

14

Small-scale

0.554

High

615282

CNRG
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

1

0

Small-scale

0.537

High

669103

RXRB
Retinoic acid receptor RXR-beta

1

16

High-throughput

0.536

High

669136

FOXR1
Forkhead box protein R1

1

3

High-throughput

0.536

High

669142

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

7

High-throughput

0.536

High

669147

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

15

High-throughput

0.536

High

421525

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.515

High

669148

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.513

High

635764

PHOS
Phosducin

1

1

Small-scale

0.501

High

669108

ARRB2
Beta-arrestin-2

1

7

Small-scale

0.501

High

669122

CAV1
Caveolin-1

1

4

Small-scale

0.501

High

669127

PHLP
Phosducin-like protein

1

1

Small-scale

0.501

High

669139

FBX25
F-box only protein 25

1

1

Small-scale

0.501

High

345386

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

474490

VIME
Vimentin

1

8

High-throughput

0.479

High

543460

VDR
Vitamin D3 receptor

1

19

Small-scale

0.479

High

669102

CALX
Calnexin

1

3

High-throughput

0.479

High

669105

PEBP1
Phosphatidylethanolamine-binding protein 1

1

2

Small-scale

0.479

High

669114

ARRB1
Beta-arrestin-1

1

7

Small-scale

0.479

High

669120

CLH1
Clathrin heavy chain 1

1

3

Small-scale

0.479

High

669123

TRAF2
TNF receptor-associated factor 2

1

14

Small-scale

0.479

High

669125

GRM1
Metabotropic glutamate receptor 1

1

1

Small-scale

0.479

High

669140

BICD2
Protein bicaudal D homolog 2

1

16

High-throughput

0.479

High

669143

BICD1
Protein bicaudal D homolog 1

1

17

High-throughput

0.479

High

669145

SMO
Protein smoothened

1

2

Small-scale

0.479

High

669151

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

15

Small-scale

0.479

High

457238

TBB5
Tubulin beta chain

1

13

Small-scale

0.445

High

105368

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

669135

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.279

Low

669141

SCFD2
Sec1 family domain-containing protein 2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025