Protein: KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)

Gene: KKCC2, CAMKK2
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q96RR4

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001934 - positive regulation of protein phosphorylation
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1082618

MK14
Mitogen-activated protein kinase 14

4

17

High-throughput

0.903

High

256003

OBSL1
Obscurin-like protein 1

4

0

High-throughput

0.857

High

871465

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

19

High-throughput

0.811

High

1034976

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

5

High-throughput

0.789

High

1082934

CDC37
Hsp90 co-chaperone Cdc37

1

4

High-throughput

0.691

High

1083224

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

12

High-throughput

0.691

High

1301345

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.691

High

1301350

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

11

High-throughput

0.691

High

49258

FEZF1
Fez family zinc finger protein 1

1

0

High-throughput

0.656

High

568768

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

15

Small-scale

0.647

High

1047954

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

18

Small-scale

0.647

High

456363

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

3

High-throughput

0.628

High

871054

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

2

8

High-throughput

0.628

High

117025

SGK1
Serine/threonine-protein kinase Sgk1

1

15

Small-scale

0.618

High

432178

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

438451

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

848453

IRAK1
Interleukin-1 receptor-associated kinase 1

1

9

High-throughput

0.618

High

1025203

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

19

High-throughput

0.618

High

1044079

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.618

High

1301343

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.618

High

395545

A4
Amyloid-beta precursor protein

2

4

High-throughput

0.602

High

670889

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

2

0

High-throughput

0.602

High

834504

HINT1
Adenosine 5'-monophosphoramidase HINT1

2

0

High-throughput

0.602

High

1298025

CEP63
Centrosomal protein of 63 kDa

2

5

High-throughput

0.590

High

217929

PRKY
Putative serine/threonine-protein kinase PRKY

1

19

High-throughput

0.575

High

483959

CALM1
Calmodulin-1

1

18

High-throughput

0.575

High

484038

CALM2
Calmodulin-2

1

18

High-throughput

0.575

High

484187

CALM3
Calmodulin-3

1

18

High-throughput

0.575

High

1301341

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

1

16

High-throughput

0.575

High

1301342

PARK7
Parkinson disease protein 7

1

1

Small-scale

0.561

High

207983

XPOT
Exportin-T

1

1

High-throughput

0.536

High

521688

MYL4
Myosin light chain 4

1

15

High-throughput

0.536

High

598285

FLNA
Filamin-A

1

6

High-throughput

0.536

High

619276

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

2

High-throughput

0.536

High

684282

1433S
14-3-3 protein sigma

1

20

High-throughput

0.536

High

944380

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

High-throughput

0.536

High

1040046

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

7

High-throughput

0.536

High

1052925

FLNC
Filamin-C

1

5

High-throughput

0.536

High

1057363

SMC1A
Structural maintenance of chromosomes protein 1A

1

5

High-throughput

0.536

High

1192360

YTHD3
YTH domain-containing family protein 3

1

5

High-throughput

0.536

High

1192603

FLIP1
Filamin-A-interacting protein 1

1

6

High-throughput

0.536

High

1198052

KAISO
Transcriptional regulator Kaiso

1

1

High-throughput

0.536

High

1268227

GCN1
Stalled ribosome sensor GCN1

1

7

High-throughput

0.536

High

1284770

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1301348

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.536

High

1301349

SMC3
Structural maintenance of chromosomes protein 3

1

2

High-throughput

0.536

High

443744

VIME
Vimentin

1

9

High-throughput

0.515

High

48466

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.513

High

311744

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

324933

DCMC
Malonyl-CoA decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

816826

IREB2
Iron-responsive element-binding protein 2

1

0

High-throughput

0.513

High

1289753

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.513

High

1301346

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1301351

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

358869

CRYAA
Alpha-crystallin A chain

1

8

High-throughput

0.501

High

808236

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

High-throughput

0.501

High

858312

TXTP
Tricarboxylate transport protein, mitochondrial

1

5

High-throughput

0.489

High

1301344

NPAS1
Neuronal PAS domain-containing protein 1

1

4

High-throughput

0.489

High

1301347

DNAI2
Dynein axonemal intermediate chain 2

1

1

High-throughput

0.489

High

320899

HS74L
Heat shock 70 kDa protein 4L

1

6

High-throughput

0.479

High

267183

GEMI
Geminin

1

0

High-throughput

0.458

High

1121621

BOREA
Borealin

1

0

High-throughput

0.458

High

973983

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

7

High-throughput

0.437

High

1132251

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

1170326

INSY2
Inhibitory synaptic factor 2A

2

0

High-throughput

0.328

High

1100124

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024