Protein: PARP2
Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)

Gene: PARP2
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q9UGN5

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0003684 - damaged DNA binding
GO:0003950 - NAD+ ADP-ribosyltransferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

455970

PARP1
Poly [ADP-ribose] polymerase 1

3

13

Small-scale

0.839

High

1347560

HPF1
Histone PARylation factor 1

2

1

Small-scale

0.812

High

1345813

RN146
E3 ubiquitin-protein ligase RNF146

5

3

Small-scale

0.712

High

1218138

APLF
Aprataxin and PNK-like factor

4

2

Small-scale

0.696

High

836795

DNLI3
DNA ligase 3

1

2

High-throughput

0.691

High

935340

H31
Histone H3.1

4

12

Small-scale

0.689

High

1203240

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

3

14

Small-scale

0.675

High

398963

HMGN2
Non-histone chromosomal protein HMG-17

3

3

Small-scale

0.670

High

417845

DPOLB
DNA polymerase beta

3

1

High-throughput

0.667

High

553980

RFA2
Replication protein A 32 kDa subunit

3

4

High-throughput

0.667

High

1026571

RFA4
Replication protein A 30 kDa subunit

3

4

High-throughput

0.667

High

1282979

H2B1A
Histone H2B type 1-A

3

17

High-throughput

0.667

High

952679

H33
Histone H3.3

3

12

Small-scale

0.660

High

918755

H2B1C
Histone H2B type 1-C/E/F/G/I

3

17

Small-scale

0.646

High

918087

H4
Histone H4

3

2

High-throughput

0.640

High

1308693

SPI2B
Spindlin-2B

3

0

High-throughput

0.638

High

524060

XRCC6
X-ray repair cross-complementing protein 6

2

5

High-throughput

0.628

High

555678

H2AX
Histone H2AX

2

15

High-throughput

0.628

High

814674

CDX1
Homeobox protein CDX-1

2

3

High-throughput

0.628

High

967094

XPC
DNA repair protein complementing XP-C cells

2

1

High-throughput

0.628

High

1200725

NAA40
N-alpha-acetyltransferase 40

2

1

High-throughput

0.628

High

1309096

MACD1
ADP-ribose glycohydrolase MACROD1

2

6

High-throughput

0.628

High

1349691

H2AW
Core histone macro-H2A.2

2

19

High-throughput

0.628

High

391953

H2A1B
Histone H2A type 1-B/E

2

13

High-throughput

0.611

High

1236556

SIR6
NAD-dependent protein deacylase sirtuin-6

2

3

High-throughput

0.611

High

578867

SDC1
Syndecan-1

2

2

High-throughput

0.574

High

713150

SDC2
Syndecan-2

2

2

High-throughput

0.574

High

1016747

CETN1
Centrin-1

2

2

High-throughput

0.574

High

370638

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

871819

HSP72
Heat shock-related 70 kDa protein 2

1

2

Small-scale

0.561

High

985472

STP2
Nuclear transition protein 2

1

0

Small-scale

0.537

High

130284

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

3

High-throughput

0.536

High

157089

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

203805

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.536

High

396996

HMGN1
Non-histone chromosomal protein HMG-14

1

1

High-throughput

0.536

High

470194

H2AZ
Histone H2A.Z

1

15

High-throughput

0.536

High

470599

H2A1
Histone H2A type 1

1

13

High-throughput

0.536

High

565059

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

566798

JUNB
Transcription factor JunB

1

1

High-throughput

0.536

High

857515

HMGA2
High mobility group protein HMGI-C

1

3

High-throughput

0.536

High

879790

DLX6
Homeobox protein DLX-6

1

8

High-throughput

0.536

High

885459

VSX2
Visual system homeobox 2

1

3

High-throughput

0.536

High

948852

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

2

High-throughput

0.536

High

981000

EMX2
Homeobox protein EMX2

1

4

High-throughput

0.536

High

1061280

NUMA1
Nuclear mitotic apparatus protein 1

1

4

High-throughput

0.536

High

1087127

H2A2C
Histone H2A type 2-C

1

13

High-throughput

0.536

High

1087460

H2B2E
Histone H2B type 2-E

1

17

High-throughput

0.536

High

1151393

H2A2A
Histone H2A type 2-A

1

13

High-throughput

0.536

High

1153960

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.536

High

1190739

HDGR2
Hepatoma-derived growth factor-related protein 2

1

12

High-throughput

0.536

High

1231259

H2B3B
Histone H2B type 3-B

1

17

High-throughput

0.536

High

1238406

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

3

High-throughput

0.536

High

1306877

FOXB1
Forkhead box protein B1

1

3

High-throughput

0.536

High

1334040

WDR76
WD repeat-containing protein 76

1

6

High-throughput

0.536

High

1343259

TF7L2
Transcription factor 7-like 2

1

9

High-throughput

0.536

High

961575

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

0

Small-scale

0.513

High

273295

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.513

High

1221493

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.513

High

1223367

CA174
UPF0688 protein C1orf174

1

0

High-throughput

0.513

High

1286314

ZN707
Zinc finger protein 707

1

0

High-throughput

0.513

High

1291232

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1343182

LHX9
LIM/homeobox protein Lhx9

1

0

High-throughput

0.513

High

426751

H10
Histone H1.0

1

1

Small-scale

0.501

High

476520

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

489324

H14
Histone H1.4

1

6

Small-scale

0.501

High

559279

H15
Histone H1.5

1

7

Small-scale

0.501

High

717403

CTNB1
Catenin beta-1

1

5

Small-scale

0.501

High

1086343

H31T
Histone H3.1t

1

12

Small-scale

0.501

High

1147975

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

1

5

Small-scale

0.501

High

1232015

S35F6
Solute carrier family 35 member F6

1

2

Small-scale

0.501

High

1256136

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

4

Small-scale

0.501

High

1264494

ING5
Inhibitor of growth protein 5

1

4

Small-scale

0.501

High

1312009

DIDO1
Death-inducer obliterator 1

1

9

Small-scale

0.501

High

1355144

DDX20
Probable ATP-dependent RNA helicase DDX20

1

2

Small-scale

0.501

High

1355146

AGO1
Protein argonaute-1

1

1

Small-scale

0.501

High

1355147

CERT
Ceramide transfer protein

1

2

Small-scale

0.501

High

1355149

ZHX2
Zinc fingers and homeoboxes protein 2

1

2

Small-scale

0.501

High

1303977

STAC
SH3 and cysteine-rich domain-containing protein

1

5

Small-scale

0.489

High

680391

SDC4
Syndecan-4

1

2

High-throughput

0.489

High

1021715

MYO1E
Unconventional myosin-Ie

1

3

High-throughput

0.489

High

1330391

UN45A
Protein unc-45 homolog A

1

5

High-throughput

0.489

High

1355145

CTNA3
Catenin alpha-3

1

1

High-throughput

0.489

High

283115

DFFB
DNA fragmentation factor subunit beta

1

0

Small-scale

0.480

High

596490

PTMS
Parathymosin

1

0

Small-scale

0.480

High

1314831

CDCA7
Cell division cycle-associated protein 7

1

0

Small-scale

0.480

High

348152

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

472958

H2AB2
Histone H2A-Bbd type 2/3

1

13

High-throughput

0.479

High

579752

XRCC1
DNA repair protein XRCC1

1

1

Small-scale

0.479

High

707781

H2B1B
Histone H2B type 1-B

1

17

High-throughput

0.479

High

799154

NKX21
Homeobox protein Nkx-2.1

1

6

High-throughput

0.479

High

800548

CBX5
Chromobox protein homolog 5

1

8

Small-scale

0.479

High

824500

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

855575

MSH6
DNA mismatch repair protein Msh6

1

6

High-throughput

0.479

High

877935

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

1029983

TIF1B
Transcription intermediary factor 1-beta

1

4

Small-scale

0.479

High

1038783

HDAC1
Histone deacetylase 1

1

7

High-throughput

0.479

High

1064231

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1269847

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1303058

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

5

Small-scale

0.479

High

1342818

BRD7
Bromodomain-containing protein 7

1

7

High-throughput

0.479

High

1343747

ANLN
Anillin

1

2

High-throughput

0.479

High

1345451

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1354741

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

966304

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1200839

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

1237509

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

60652

VP37C
Vacuolar protein sorting-associated protein 37C

1

3

Small-scale

0.457

High

166057

SYNJ2
Synaptojanin-2

1

1

Small-scale

0.457

High

297427

MYO1D
Unconventional myosin-Id

1

3

Small-scale

0.457

High

307140

RTN3
Reticulon-3

1

1

Small-scale

0.457

High

708256

ERD22
ER lumen protein-retaining receptor 2

1

1

Small-scale

0.457

High

901329

NCALD
Neurocalcin-delta

1

2

Small-scale

0.457

High

1156442

PP4R4
Serine/threonine-protein phosphatase 4 regulatory subunit 4

1

2

Small-scale

0.457

High

1189159

PRIC2
Prickle-like protein 2

1

3

Small-scale

0.457

High

1216168

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

3

Small-scale

0.457

High

1237703

ZN321
Putative protein ZNF321

1

1

Small-scale

0.457

High

1312559

CRDL1
Chordin-like protein 1

1

1

Small-scale

0.457

High

1313623

ZN747
Zinc finger protein 747

1

1

Small-scale

0.457

High

375045

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.445

High

1349128

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

901838

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.438

High

1172132

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1344805

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.417

High

555211

CD44
CD44 antigen

2

0

High-throughput

0.328

High

1285036

ZN428
Zinc finger protein 428

2

0

High-throughput

0.328

High

949070

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

49978

F168B
Myelin-associated neurite-outgrowth inhibitor

1

0

Small-scale

0.261

Low

130620

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

Small-scale

0.261

Low

392944

IFN16
Interferon alpha-16

1

0

Small-scale

0.261

Low

398306

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

0

Small-scale

0.261

Low

581255

LFA3
Lymphocyte function-associated antigen 3

1

0

Small-scale

0.261

Low

837661

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

0

Small-scale

0.261

Low

1055030

HABP2
Hyaluronan-binding protein 2

1

0

Small-scale

0.261

Low

1134713

DIK1A
Divergent protein kinase domain 1A

1

0

Small-scale

0.261

Low

1139939

FHI2A
FHF complex subunit HOOK interacting protein 2A

1

0

Small-scale

0.261

Low

1190419

HAUS6
HAUS augmin-like complex subunit 6

1

0

Small-scale

0.261

Low

1223028

LAS2
Lung adenoma susceptibility protein 2

1

0

Small-scale

0.261

Low

1223512

ASTRC
Protein Aster-C

1

0

Small-scale

0.261

Low

1235133

CCD33
Coiled-coil domain-containing protein 33

1

0

Small-scale

0.261

Low

1245414

OR4D6
Olfactory receptor 4D6

1

0

Small-scale

0.261

Low

1260080

CT55
Cancer/testis antigen 55

1

0

Small-scale

0.261

Low

1261154

CC107
Coiled-coil domain-containing protein 107

1

0

Small-scale

0.261

Low

1285161

LDAF1
Lipid droplet assembly factor 1

1

0

Small-scale

0.261

Low

1315096

TM2D2
TM2 domain-containing protein 2

1

0

Small-scale

0.261

Low

1315678

TMM59
Transmembrane protein 59

1

0

Small-scale

0.261

Low

1330339

TPK1
Thiamin pyrophosphokinase 1

1

0

Small-scale

0.261

Low

1335296

IL21
Interleukin-21

1

0

Small-scale

0.261

Low

1355148

TEST
Testisin

1

0

Small-scale

0.261

Low

101255

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024