Protein: HOOK2
Protein Hook homolog 2 (h-hook2) (hHK2)

Gene: HOOK2
Organism: Homo sapiens
Interactions: 202
UniProt ID: Q96ED9

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005802 - trans-Golgi network
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0005874 - microtubule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1388861

AKTIP
AKT-interacting protein

10

4

Small-scale

0.979

High

1388828

HOOK2
Protein Hook homolog 2

3

19

Small-scale

0.843

High

1328725

FHI1B
FHF complex subunit HOOK-interacting protein 1B

2

13

Small-scale

0.767

High

1291558

HOOK3
Protein Hook homolog 3

1

19

Small-scale

0.713

High

1388881

HOOK1
Protein Hook homolog 1

1

19

Small-scale

0.713

High

1145909

RBP1
RalA-binding protein 1

5

14

High-throughput

0.713

High

1388851

AP1M1
AP-1 complex subunit mu-1

4

8

Small-scale

0.700

High

1388886

TN13B
Tumor necrosis factor ligand superfamily member 13B

4

2

High-throughput

0.699

High

1215292

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

4

5

High-throughput

0.683

High

288488

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

3

18

High-throughput

0.667

High

881734

FNTB
Protein farnesyltransferase subunit beta

3

2

High-throughput

0.667

High

906141

AL3A2
Aldehyde dehydrogenase family 3 member A2

3

3

High-throughput

0.667

High

1181415

P3H1
Prolyl 3-hydroxylase 1

3

1

High-throughput

0.662

High

216510

SUV91
Histone-lysine N-methyltransferase SUV39H1

4

1

High-throughput

0.642

High

1219952

FHI2A
FHF complex subunit HOOK interacting protein 2A

1

13

High-throughput

0.640

High

1290240

FHI2B
FHF complex subunit HOOK-interacting protein 2B

1

13

High-throughput

0.640

High

1332487

POC5
Centrosomal protein POC5

2

3

High-throughput

0.628

High

1180476

C19L2
CWF19-like protein 2

3

2

High-throughput

0.616

High

1198835

ZC21C
Zinc finger C2HC domain-containing protein 1C

3

1

High-throughput

0.616

High

585080

ZN250
Zinc finger protein 250

3

1

High-throughput

0.609

High

1362511

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

3

2

High-throughput

0.609

High

1388849

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

2

5

High-throughput

0.608

High

214102

FGF16
Fibroblast growth factor 16

2

2

High-throughput

0.606

High

407506

K2C1
Keratin, type II cytoskeletal 1

2

9

High-throughput

0.606

High

478714

HXB5
Homeobox protein Hox-B5

2

6

High-throughput

0.606

High

680980

PSA1
Proteasome subunit alpha type-1

2

1

High-throughput

0.606

High

684348

DDX6
Probable ATP-dependent RNA helicase DDX6

2

3

High-throughput

0.606

High

935594

MFAP1
Microfibrillar-associated protein 1

2

1

High-throughput

0.606

High

941038

HDAC4
Histone deacetylase 4

2

19

High-throughput

0.606

High

1057642

CDK18
Cyclin-dependent kinase 18

2

18

High-throughput

0.606

High

1117980

PKP1
Plakophilin-1

2

14

High-throughput

0.606

High

1119768

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

17

High-throughput

0.606

High

1185303

F161A
Protein FAM161A

2

4

High-throughput

0.606

High

1214358

SYT6
Synaptotagmin-6

2

3

High-throughput

0.606

High

1228882

ZFY26
Zinc finger FYVE domain-containing protein 26

2

17

High-throughput

0.606

High

1239726

PPR18
Phostensin

2

8

High-throughput

0.606

High

1335884

RN169
E3 ubiquitin-protein ligase RNF169

2

11

High-throughput

0.606

High

1340855

GA2L2
GAS2-like protein 2

2

8

High-throughput

0.606

High

1348414

LNX1
E3 ubiquitin-protein ligase LNX

2

10

High-throughput

0.606

High

1361426

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

16

High-throughput

0.606

High

1388836

LRGUK
Leucine-rich repeat and guanylate kinase domain-containing protein

2

9

High-throughput

0.606

High

1388843

PKP2
Plakophilin-2

2

18

High-throughput

0.606

High

1388846

SYT17
Synaptotagmin-17

2

3

High-throughput

0.606

High

1388847

TCHP
Trichoplein keratin filament-binding protein

2

18

High-throughput

0.606

High

1388853

TSG10
Testis-specific gene 10 protein

2

20

High-throughput

0.606

High

1388856

ATG5
Autophagy protein 5

2

3

High-throughput

0.606

High

1388860

SH24A
SH2 domain-containing protein 4A

2

14

High-throughput

0.606

High

1388862

KIF9
Kinesin-like protein KIF9

2

15

High-throughput

0.606

High

1388864

NEK6
Serine/threonine-protein kinase Nek6

2

20

High-throughput

0.606

High

1388865

CABP2
Calcium-binding protein 2

2

2

High-throughput

0.606

High

1388866

PAR11
Protein mono-ADP-ribosyltransferase PARP11

2

3

High-throughput

0.606

High

1388870

AIRIM
AFG2-interacting ribosome maturation factor

2

1

High-throughput

0.606

High

1388872

RCOR3
REST corepressor 3

2

5

High-throughput

0.606

High

1388876

CYH4
Cytohesin-4

2

5

High-throughput

0.606

High

1388880

RABX5
Rab5 GDP/GTP exchange factor

2

4

High-throughput

0.606

High

1388887

TBC30
TBC1 domain family member 30

2

4

High-throughput

0.606

High

1388890

IPP
Actin-binding protein IPP

2

5

High-throughput

0.606

High

640257

EPHA1
Ephrin type-A receptor 1

3

10

High-throughput

0.604

High

956975

CXCR4
C-X-C chemokine receptor type 4

2

6

High-throughput

0.601

High

1022931

EFNB1
Ephrin-B1

2

6

High-throughput

0.601

High

1086181

CETN1
Centrin-1

2

3

High-throughput

0.601

High

1316956

FAM9B
Protein FAM9B

2

1

High-throughput

0.601

High

1388874

ZBT47
Zinc finger and BTB domain-containing protein 47

3

8

High-throughput

0.597

High

1247963

ANR11
Ankyrin repeat domain-containing protein 11

2

10

High-throughput

0.584

High

187773

EIF3D
Eukaryotic translation initiation factor 3 subunit D

2

0

High-throughput

0.580

High

221278

DCX
Neuronal migration protein doublecortin

2

0

High-throughput

0.580

High

369196

OAS1
2'-5'-oligoadenylate synthase 1

2

0

High-throughput

0.580

High

808140

CDN1A
Cyclin-dependent kinase inhibitor 1

2

0

High-throughput

0.580

High

1118951

BYST
Bystin

2

0

High-throughput

0.580

High

1196962

FWCH1
FLYWCH-type zinc finger-containing protein 1

2

0

High-throughput

0.580

High

1309202

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.580

High

1388829

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

1388830

CEP95
Centrosomal protein of 95 kDa

2

0

High-throughput

0.580

High

1388844

F110A
Protein FAM110A

2

0

High-throughput

0.580

High

1388854

SPC1L
Speriolin-like protein

2

0

High-throughput

0.580

High

1388855

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

1053459

FHI1A
FHF complex subunit HOOK-interacting protein 1A

1

13

High-throughput

0.575

High

587359

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

2

2

High-throughput

0.574

High

630180

ACM3
Muscarinic acetylcholine receptor M3

2

1

High-throughput

0.574

High

1388879

DS13B
Dual specificity protein phosphatase 13B

1

11

High-throughput

0.573

High

1386258

HAUS1
HAUS augmin-like complex subunit 1

1

1

High-throughput

0.560

High

1326207

PNKD
Probable thioesterase PNKD

2

5

High-throughput

0.558

High

567187

ZNF35
Zinc finger protein 35

2

4

High-throughput

0.553

High

933877

GEM
GTP-binding protein GEM

2

7

High-throughput

0.553

High

945544

RGS8
Regulator of G-protein signaling 8

2

4

High-throughput

0.553

High

1065834

ZN844
Zinc finger protein 844

2

2

High-throughput

0.553

High

1111185

SNW1
SNW domain-containing protein 1

2

4

High-throughput

0.553

High

1187668

T10IP
Testis-specific protein 10-interacting protein

2

1

High-throughput

0.553

High

1213243

ZN648
Zinc finger protein 648

2

5

High-throughput

0.553

High

1220030

TTC23
Tetratricopeptide repeat protein 23

2

2

High-throughput

0.553

High

1241436

ZFP1
Zinc finger protein 1 homolog

2

3

High-throughput

0.553

High

1253115

ZN497
Zinc finger protein 497

2

1

High-throughput

0.553

High

1277118

ZN572
Zinc finger protein 572

2

4

High-throughput

0.553

High

1327439

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

2

1

High-throughput

0.553

High

1331080

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

3

High-throughput

0.553

High

1347701

ZN417
Zinc finger protein 417

2

2

High-throughput

0.553

High

1385245

LENG1
Leukocyte receptor cluster member 1

2

1

High-throughput

0.553

High

1388832

RBM41
RNA-binding protein 41

2

2

High-throughput

0.553

High

1388837

ZNF48
Zinc finger protein 48

2

2

High-throughput

0.553

High

1388838

F161B
Protein FAM161B

2

4

High-throughput

0.553

High

1388839

ZN587
Zinc finger protein 587

2

2

High-throughput

0.553

High

1388863

CBX8
Chromobox protein homolog 8

2

2

High-throughput

0.553

High

1388868

TB22B
TBC1 domain family member 22B

2

3

High-throughput

0.553

High

1388878

ZN107
Zinc finger protein 107

2

1

High-throughput

0.553

High

1388888

ZN835
Zinc finger protein 835

2

2

High-throughput

0.553

High

50657

HACL2
2-hydroxyacyl-CoA lyase 2

2

1

High-throughput

0.549

High

1101623

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

7

High-throughput

0.549

High

1291860

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

2

7

High-throughput

0.549

High

1370799

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.547

High

1388892

X5D778
Ankyrin repeat domain 11 isoform A

2

12

High-throughput

0.544

High

159250

ABLM1
Actin-binding LIM protein 1

1

6

High-throughput

0.541

High

332031

KAT7
Histone acetyltransferase KAT7

1

2

High-throughput

0.541

High

1134025

ZN638
Zinc finger protein 638

1

1

High-throughput

0.541

High

1364961

TSC1
Hamartin

1

20

High-throughput

0.541

High

1388873

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

1

High-throughput

0.541

High

219997

XRCC3
DNA repair protein XRCC3

1

5

High-throughput

0.536

High

1152195

MARE1
Microtubule-associated protein RP/EB family member 1

1

8

High-throughput

0.536

High

1327759

LRA25
Leucine repeat adapter protein 25

1

2

High-throughput

0.536

High

1388852

UBXN6
UBX domain-containing protein 6

1

3

High-throughput

0.536

High

1388882

AP4E1
AP-4 complex subunit epsilon-1

1

11

Small-scale

0.536

High

352790

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.518

High

1086668

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.518

High

261540

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

125848

AP4M1
AP-4 complex subunit mu-1

1

8

Small-scale

0.508

High

447830

TPM3
Tropomyosin alpha-3 chain

1

15

High-throughput

0.508

High

1090363

EPS8
Epidermal growth factor receptor kinase substrate 8

1

11

High-throughput

0.494

High

1234670

IQCE
IQ domain-containing protein E

1

18

High-throughput

0.494

High

133297

P2Y10
Putative P2Y purinoceptor 10

1

8

High-throughput

0.489

High

936107

PAR2
Proteinase-activated receptor 2

1

8

High-throughput

0.489

High

1249827

BTNL9
Butyrophilin-like protein 9

1

10

High-throughput

0.489

High

1291652

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

1308509

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

7

High-throughput

0.489

High

1323279

KT222
Keratin-like protein KRT222

1

20

High-throughput

0.489

High

1325819

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

3

High-throughput

0.489

High

1388835

F167A
Protein FAM167A

1

3

High-throughput

0.489

High

1388842

NPAS1
Neuronal PAS domain-containing protein 1

1

13

High-throughput

0.489

High

1388833

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

0

High-throughput

0.486

High

1150154

TCEA2
Transcription elongation factor A protein 2

1

3

High-throughput

0.481

High

1350686

CCHCR
Coiled-coil alpha-helical rod protein 1

1

18

High-throughput

0.481

High

1386661

AP2M1
AP-2 complex subunit mu

1

8

Small-scale

0.481

High

1388871

ITSN2
Intersectin-2

1

14

High-throughput

0.481

High

1388885

RNF6
E3 ubiquitin-protein ligase RNF6

1

11

High-throughput

0.481

High

1245404

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

Small-scale

0.480

High

173207

XPO1
Exportin-1

1

4

High-throughput

0.479

High

363699

EGFR
Epidermal growth factor receptor

1

19

High-throughput

0.479

High

409032

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

468684

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.479

High

623480

RO52
E3 ubiquitin-protein ligase TRIM21

1

10

High-throughput

0.479

High

888804

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

9

Small-scale

0.479

High

1113957

CUL3
Cullin-3

1

18

High-throughput

0.479

High

1383642

VP33A
Vacuolar protein sorting-associated protein 33A

1

5

High-throughput

0.479

High

1388848

CP250
Centrosome-associated protein CEP250

1

17

High-throughput

0.479

High

1388857

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

2

Small-scale

0.479

High

1388875

ZRAN1
Ubiquitin thioesterase ZRANB1

1

16

High-throughput

0.479

High

1388877

XPO7
Exportin-7

1

4

High-throughput

0.479

High

97290

E9PSE9
Coiled-coil domain containing 198

1

1

High-throughput

0.470

High

1066094

Q08E77
UTP14, U3 small nucleolar ribonucleoprotein, homolog C

1

5

High-throughput

0.470

High

1388831

A26L1
Putative ankyrin repeat domain-containing protein 26-like 1

1

1

High-throughput

0.470

High

1388858

KLK15
Kallikrein-15

1

3

High-throughput

0.464

High

1363749

PSMF1
Proteasome inhibitor PI31 subunit

1

0

High-throughput

0.460

High

166389

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.445

High

171551

S27A2
Long-chain fatty acid transport protein 2

1

6

High-throughput

0.445

High

564191

CFTR
Cystic fibrosis transmembrane conductance regulator

1

14

High-throughput

0.445

High

638495

FPR1
fMet-Leu-Phe receptor

1

6

High-throughput

0.445

High

683308

TNR5
Tumor necrosis factor receptor superfamily member 5

1

6

High-throughput

0.445

High

1388840

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.445

High

1388869

FAME
Factor associated with metabolism and energy

1

1

High-throughput

0.439

High

430225

JUN
Transcription factor Jun

1

5

High-throughput

0.437

High

1290252

MGDP1
Magnesium-dependent phosphatase 1

1

1

High-throughput

0.437

High

3319

A0A0S2Z4G9
Ring finger protein 6 isoform 2

1

6

High-throughput

0.417

High

292278

S22A3
Solute carrier family 22 member 3

1

2

High-throughput

0.407

High

628441

KLK2
Kallikrein-2

1

3

High-throughput

0.407

High

1167098

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

5

High-throughput

0.407

High

1240929

S27A4
Long-chain fatty acid transport protein 4

1

6

High-throughput

0.407

High

1243649

S27A1
Long-chain fatty acid transport protein 1

1

6

High-throughput

0.407

High

1357823

S35F5
Solute carrier family 35 member F5

1

1

High-throughput

0.407

High

1388867

S22AB
Solute carrier family 22 member 11

1

2

High-throughput

0.407

High

1388883

XCT
Cystine/glutamate transporter

1

2

High-throughput

0.407

High

1388889

S27A6
Long-chain fatty acid transport protein 6

1

6

High-throughput

0.407

High

845466

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

0

High-throughput

0.347

High

1276089

KANL1
KAT8 regulatory NSL complex subunit 1

2

0

High-throughput

0.334

High

1330728

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

506760

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

1153698

MPPD2
Metallophosphoesterase MPPED2

2

0

High-throughput

0.316

High

1214494

PPR26
Protein phosphatase 1 regulatory subunit 26

2

0

High-throughput

0.316

High

1244206

MORN3
MORN repeat-containing protein 3

2

0

High-throughput

0.316

High

1295084

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1359876

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.316

High

1370615

GPKOW
G-patch domain and KOW motifs-containing protein

2

0

High-throughput

0.316

High

1388841

PRP18
Pre-mRNA-splicing factor 18

2

0

High-throughput

0.316

High

1388850

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.316

High

1388884

FA50B
Protein FAM50B

2

0

High-throughput

0.316

High

1328385

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.304

High

1256455

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.282

High

1272248

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.282

High

1388845

PIMRE
Protein PIMREG

1

0

High-throughput

0.282

High

1388859

RIBC2
RIB43A-like with coiled-coils protein 2

1

0

High-throughput

0.282

High

338741

NPTXR
Neuronal pentraxin receptor

1

0

High-throughput

0.279

Low

1388891

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1334310

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.232

Low

1388834

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025