Protein: PKN1
Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)

Gene: PKN1
Organism: Homo sapiens
Interactions: 147
UniProt ID: Q16512

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0001783 - B cell apoptotic process
GO:0001933 - negative regulation of protein phosphorylation
GO:0002634 - regulation of germinal center formation
GO:0002637 - regulation of immunoglobulin production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

900513

RHOA
Transforming protein RhoA

5

20

Small-scale

0.929

High

915705

RHOB
Rho-related GTP-binding protein RhoB

3

20

Small-scale

0.834

High

227574

PRKN
E3 ubiquitin-protein ligase parkin

2

19

High-throughput

0.754

High

864832

MK12
Mitogen-activated protein kinase 12

1

20

Small-scale

0.747

High

237397

CCNT2
Cyclin-T2

1

8

Small-scale

0.740

High

175684

TRI18
E3 ubiquitin-protein ligase Midline-1

1

17

High-throughput

0.740

High

1081920

PKN1
Serine/threonine-protein kinase N1

1

17

Small-scale

0.735

High

1032968

PLD1
Phospholipase D1

1

4

Small-scale

0.724

High

182165

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

19

Small-scale

0.713

High

673585

MPIP3
M-phase inducer phosphatase 3

1

0

Small-scale

0.708

High

1081975

HOME3
Homer protein homolog 3

4

5

High-throughput

0.703

High

1081921

PKN2
Serine/threonine-protein kinase N2

1

18

High-throughput

0.691

High

1081969

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

11

High-throughput

0.691

High

1081986

PLAL2
Zinc finger protein PLAGL2

1

1

High-throughput

0.691

High

1020682

TRAF2
TNF receptor-associated factor 2

3

13

Small-scale

0.679

High

1071184

K1H1
Keratin, type I cuticular Ha1

3

13

High-throughput

0.675

High

967560

CDR2
Cerebellar degeneration-related protein 2

4

0

Small-scale

0.670

High

796227

MAGAA
Melanoma-associated antigen 10

3

3

High-throughput

0.667

High

805426

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

16

Small-scale

0.665

High

854731

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

17

Small-scale

0.665

High

987823

GABP1
GA-binding protein subunit beta-1

1

7

High-throughput

0.665

High

1081937

CCNJL
Cyclin-J-like protein

1

10

High-throughput

0.665

High

1081978

ZN581
Zinc finger protein 581

1

5

High-throughput

0.665

High

1081983

IKZF3
Zinc finger protein Aiolos

1

1

High-throughput

0.665

High

1081985

ZN232
Zinc finger protein 232

1

3

High-throughput

0.665

High

1023672

TRAF1
TNF receptor-associated factor 1

3

7

Small-scale

0.658

High

1081979

ZN282
Zinc finger protein 282

1

1

High-throughput

0.656

High

1081947

KBTB8
Kelch repeat and BTB domain-containing protein 8

3

4

Small-scale

0.656

High

536847

TRI27
Zinc finger protein RFP

3

7

Small-scale

0.653

High

925307

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

443540

VIME
Vimentin

2

13

Small-scale

0.641

High

976219

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.638

High

1081965

AKAP9
A-kinase anchor protein 9

2

11

Small-scale

0.633

High

1081951

ZFP90
Zinc finger protein 90 homolog

1

0

High-throughput

0.630

High

422189

NFL
Neurofilament light polypeptide

2

12

Small-scale

0.618

High

384909

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.618

High

408621

KPCB
Protein kinase C beta type

1

16

Small-scale

0.618

High

431894

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

438206

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

521554

ACTN1
Alpha-actinin-1

1

2

Small-scale

0.618

High

681870

AKT1
RAC-alpha serine/threonine-protein kinase

1

16

Small-scale

0.618

High

779490

CCNF
Cyclin-F

1

10

High-throughput

0.618

High

1078187

MK11
Mitogen-activated protein kinase 11

1

20

Small-scale

0.618

High

1081922

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.618

High

1081930

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1081971

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.618

High

1081976

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

4

Small-scale

0.618

High

994900

GOGA2
Golgin subfamily A member 2

3

9

High-throughput

0.616

High

280592

KRT34
Keratin, type I cuticular Ha4

2

12

High-throughput

0.606

High

280798

KRT36
Keratin, type I cuticular Ha6

2

12

High-throughput

0.606

High

280881

KRT37
Keratin, type I cuticular Ha7

2

13

High-throughput

0.606

High

444376

K1C19
Keratin, type I cytoskeletal 19

2

11

High-throughput

0.606

High

445057

K1C16
Keratin, type I cytoskeletal 16

2

11

High-throughput

0.606

High

656472

PSB4
Proteasome subunit beta type-4

2

3

High-throughput

0.606

High

869378

HAP1
Huntingtin-associated protein 1

2

6

High-throughput

0.606

High

944033

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.606

High

1081925

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

10

High-throughput

0.606

High

1081926

INT11
Integrator complex subunit 11

2

2

High-throughput

0.606

High

1081936

CEP57
Centrosomal protein of 57 kDa

2

2

High-throughput

0.606

High

1081943

USBP1
Harmonin-binding protein USHBP1

2

6

High-throughput

0.606

High

1081945

PNMA1
Paraneoplastic antigen Ma1

2

4

High-throughput

0.606

High

1081957

KRT35
Keratin, type I cuticular Ha5

2

13

High-throughput

0.606

High

1081959

HAUS1
HAUS augmin-like complex subunit 1

2

1

High-throughput

0.606

High

1081964

SPAG5
Sperm-associated antigen 5

2

8

High-throughput

0.606

High

1081968

TSG10
Testis-specific gene 10 protein

2

7

High-throughput

0.606

High

1081973

PICK1
PRKCA-binding protein

2

7

High-throughput

0.606

High

1081980

ZRAN1
Ubiquitin thioesterase ZRANB1

2

6

High-throughput

0.606

High

1081981

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

14

High-throughput

0.606

High

58758

FUCM
Fucose mutarotase

2

0

High-throughput

0.602

High

50427

SYCE3
Synaptonemal complex central element protein 3

2

0

High-throughput

0.580

High

124872

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

0

High-throughput

0.580

High

253023

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1081938

CC103
Coiled-coil domain-containing protein 103

2

0

High-throughput

0.580

High

1081939

UBR2
E3 ubiquitin-protein ligase UBR2

2

0

High-throughput

0.580

High

1081948

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.580

High

1081949

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.580

High

1081963

RAB3I
Rab-3A-interacting protein

2

0

High-throughput

0.580

High

1081966

LRC61
Leucine-rich repeat-containing protein 61

2

0

High-throughput

0.580

High

1081970

GO45
Golgin-45

2

0

High-throughput

0.580

High

1081972

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

0

High-throughput

0.580

High

1081974

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.580

High

1081982

SRTD3
SERTA domain-containing protein 3

2

0

High-throughput

0.580

High

1078462

NDF2
Neurogenic differentiation factor 2

1

2

Small-scale

0.573

High

580029

K1C15
Keratin, type I cytoskeletal 15

1

11

High-throughput

0.573

High

1081940

CE57L
Centrosomal protein CEP57L1

1

2

High-throughput

0.573

High

1079222

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.558

High

62311

GG6L9
Golgin subfamily A member 6-like protein 9

2

10

High-throughput

0.553

High

1081928

ATL4
ADAMTS-like protein 4

2

1

High-throughput

0.553

High

1081989

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.549

High

256264

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

6

High-throughput

0.536

High

1081950

RBCC1
RB1-inducible coiled-coil protein 1

1

13

High-throughput

0.536

High

1081956

S39A7
Zinc transporter SLC39A7

1

1

High-throughput

0.536

High

591339

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

7

Small-scale

0.528

High

517803

NFH
Neurofilament heavy polypeptide

1

17

Small-scale

0.527

High

394785

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.515

High

644049

EF1G
Elongation factor 1-gamma

1

7

High-throughput

0.515

High

1054136

BECN1
Beclin-1

1

1

High-throughput

0.515

High

1081927

Q6PJH3
A kinase

1

2

High-throughput

0.515

High

1081941

MIER1
Mesoderm induction early response protein 1

1

2

High-throughput

0.515

High

1081942

KCD17
BTB/POZ domain-containing protein KCTD17

1

4

High-throughput

0.515

High

1081977

STMN3
Stathmin-3

1

1

High-throughput

0.515

High

1081984

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.515

High

1081952

AEN
Apoptosis-enhancing nuclease

1

0

High-throughput

0.513

High

1081967

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.513

High

362090

MBP
Myelin basic protein

1

3

Small-scale

0.501

High

497097

TAU
Microtubule-associated protein tau

1

12

Small-scale

0.501

High

670047

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

Small-scale

0.501

High

788206

CASP3
Caspase-3

1

4

Small-scale

0.501

High

1081932

H32
Histone H3.2

1

7

Small-scale

0.501

High

1081988

HDAC5
Histone deacetylase 5

1

7

Small-scale

0.501

High

232186

KDM1A
Lysine-specific histone demethylase 1A

1

3

Small-scale

0.500

High

1081962

ZN488
Zinc finger protein 488

1

0

High-throughput

0.493

High

661269

S10A2
Protein S100-A2

1

7

High-throughput

0.489

High

1081924

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1081929

CERS6
Ceramide synthase 6

1

3

High-throughput

0.489

High

608918

SPR2D
Small proline-rich protein 2D

1

0

High-throughput

0.486

High

428232

TBB5
Tubulin beta chain

1

9

Small-scale

0.479

High

651316

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

717119

CTNB1
Catenin beta-1

1

5

High-throughput

0.479

High

720568

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

1035449

SMAD4
Mothers against decapentaplegic homolog 4

1

9

High-throughput

0.479

High

1067965

PDK1
[Pyruvate dehydrogenase

1

4

Small-scale

0.479

High

1071882

PCBP1
Poly(rC)-binding protein 1

1

4

Small-scale

0.479

High

1081933

TBA1A
Tubulin alpha-1A chain

1

12

Small-scale

0.479

High

1081934

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1081946

ABCF1
ATP-binding cassette sub-family F member 1

1

2

High-throughput

0.479

High

1081958

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1081987

PA2G4
Proliferation-associated protein 2G4

1

1

Small-scale

0.479

High

1081953

THAP3
THAP domain-containing protein 3

1

1

High-throughput

0.470

High

211754

BUD23
Probable 18S rRNA

1

0

High-throughput

0.460

High

120931

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

1081960

CC136
Coiled-coil domain-containing protein 136

1

10

High-throughput

0.439

High

887863

CD81
CD81 antigen

1

3

High-throughput

0.437

High

1081944

ARL10
ADP-ribosylation factor-like protein 10

1

5

High-throughput

0.437

High

1081931

RHEX
Regulator of hemoglobinization and erythroid cell expansion protein

3

0

High-throughput

0.347

High

1081990

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.328

High

67087

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

269422

STX11
Syntaxin-11

2

0

High-throughput

0.316

High

546616

ARSA
Arylsulfatase A

2

0

High-throughput

0.316

High

1023466

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.316

High

1081935

K1328
Protein hinderin

2

0

High-throughput

0.316

High

1081955

DYDC1
DPY30 domain-containing protein 1

2

0

High-throughput

0.316

High

1081961

CC138
Coiled-coil domain-containing protein 138

2

0

High-throughput

0.316

High

451822

INHBB
Inhibin beta B chain

1

0

High-throughput

0.279

Low

1081954

CB015
Uncharacterized protein C2orf15

1

0

High-throughput

0.268

Low

1081923

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024