Protein: DET1
DET1 homolog (De-etiolated-1 homolog)

Gene: DET1
Organism: Homo sapiens
Interactions: 158
UniProt ID: Q7L5Y6

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0016567 - protein ubiquitination
GO:0031461 - cullin-RING ubiquitin ligase complex
GO:0031464 - Cul4A-RING E3 ubiquitin ligase complex
GO:0031625 - ubiquitin protein ligase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1082254

DDB1
DNA damage-binding protein 1

9

2

Small-scale

0.750

High

1043080

CUL4A
Cullin-4A

7

2

Small-scale

0.743

High

1185064

COP1
E3 ubiquitin-protein ligase COP1

10

0

Small-scale

0.722

High

1043430

CUL4B
Cullin-4B

4

2

Small-scale

0.703

High

345475

FOS
Protein c-Fos

4

4

High-throughput

0.694

High

1185066

TRIB2
Tribbles homolog 2

3

2

High-throughput

0.675

High

1185081

TRIB1
Tribbles homolog 1

3

3

High-throughput

0.675

High

548311

FOSL2
Fos-related antigen 2

3

3

High-throughput

0.667

High

781145

ETV5
ETS translocation variant 5

3

3

High-throughput

0.667

High

840438

ETV1
ETS translocation variant 1

3

3

High-throughput

0.667

High

851831

UB2E1
Ubiquitin-conjugating enzyme E2 E1

3

3

Small-scale

0.667

High

1185070

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

3

Small-scale

0.667

High

1185092

CSN7B
COP9 signalosome complex subunit 7b

3

1

High-throughput

0.667

High

1185099

CSN7A
COP9 signalosome complex subunit 7a

3

1

High-throughput

0.667

High

1185088

DDA1
DET1- and DDB1-associated protein 1

4

0

Small-scale

0.664

High

1185068

CSN5
COP9 signalosome complex subunit 5

3

0

High-throughput

0.638

High

566769

JUNB
Transcription factor JunB

2

1

High-throughput

0.628

High

897268

CSN2
COP9 signalosome complex subunit 2

2

2

High-throughput

0.628

High

1024179

CSN1
COP9 signalosome complex subunit 1

2

1

High-throughput

0.628

High

1185077

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

3

High-throughput

0.628

High

1185104

CSN3
COP9 signalosome complex subunit 3

2

2

High-throughput

0.628

High

1184894

CSN6
COP9 signalosome complex subunit 6

2

0

High-throughput

0.602

High

1185086

CSN4
COP9 signalosome complex subunit 4

2

0

High-throughput

0.602

High

432000

HS90A
Heat shock protein HSP 90-alpha

2

2

High-throughput

0.584

High

438304

HS90B
Heat shock protein HSP 90-beta

2

3

High-throughput

0.584

High

684839

STIP1
Stress-induced-phosphoprotein 1

2

2

High-throughput

0.584

High

1185061

STK40
Serine/threonine-protein kinase 40

2

3

High-throughput

0.574

High

1185094

CYBP
Calcyclin-binding protein

2

0

High-throughput

0.559

High

504301

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.536

High

1185080

TRIB3
Tribbles homolog 3

1

3

High-throughput

0.536

High

1185057

NUDC3
NudC domain-containing protein 3

2

2

High-throughput

0.533

High

579351

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

0

High-throughput

0.513

High

629147

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

1185060

SIX5
Homeobox protein SIX5

1

0

High-throughput

0.513

High

1185083

CSN8
COP9 signalosome complex subunit 8

1

0

High-throughput

0.513

High

794551

ETV4
ETS translocation variant 4

1

3

High-throughput

0.500

High

1185100

DNJB4
DnaJ homolog subfamily B member 4

1

1

High-throughput

0.489

High

73153

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

2

High-throughput

0.479

High

136036

ACACB
Acetyl-CoA carboxylase 2

1

4

High-throughput

0.479

High

180357

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.479

High

202656

TXNL1
Thioredoxin-like protein 1

1

3

High-throughput

0.479

High

323427

TTC4
Tetratricopeptide repeat protein 4

1

7

High-throughput

0.479

High

402193

JUN
Transcription factor Jun

1

1

Small-scale

0.479

High

495557

THIO
Thioredoxin

1

1

High-throughput

0.479

High

538292

ENPL
Endoplasmin

1

2

High-throughput

0.479

High

542750

ETS2
Protein C-ets-2

1

3

Small-scale

0.479

High

551755

DESP
Desmoplakin

1

1

High-throughput

0.479

High

671849

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.479

High

681504

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.479

High

921319

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.479

High

943317

TCPB
T-complex protein 1 subunit beta

1

1

High-throughput

0.479

High

970803

DSG1
Desmoglein-1

1

1

High-throughput

0.479

High

1082125

CRY1
Cryptochrome-1

1

1

Small-scale

0.479

High

1115731

CRY2
Cryptochrome-2

1

1

Small-scale

0.479

High

1120577

Q53FC7
Heat shock 70kDa protein 6

1

1

High-throughput

0.479

High

1185059

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.479

High

1185103

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.479

High

1185107

SGT1
Protein SGT1 homolog

1

3

High-throughput

0.479

High

1185108

MAGD1
Melanoma-associated antigen D1

1

1

High-throughput

0.479

High

127305

IPO5
Importin-5

1

0

High-throughput

0.458

High

150724

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

0

High-throughput

0.458

High

295643

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.458

High

323857

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

376099

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

382050

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

389585

TYSY
Thymidylate synthase

1

0

High-throughput

0.458

High

418404

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

426677

H10
Histone H1.0

1

0

High-throughput

0.458

High

475967

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

598196

FLNA
Filamin-A

1

0

High-throughput

0.458

High

670842

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

728543

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.458

High

813084

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.458

High

818187

SOX2
Transcription factor SOX-2

1

0

Small-scale

0.458

High

858644

PPP5
Serine/threonine-protein phosphatase 5

1

0

High-throughput

0.458

High

868239

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

875063

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

919434

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.458

High

923083

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

929529

RACK1
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

962836

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

969598

CENPE
Centromere-associated protein E

1

0

High-throughput

0.458

High

971238

H11
Histone H1.1

1

0

High-throughput

0.458

High

1030097

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.458

High

1047418

RUNX2
Runt-related transcription factor 2

1

0

High-throughput

0.458

High

1073780

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

0

High-throughput

0.458

High

1117622

SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

1

0

High-throughput

0.458

High

1146416

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.458

High

1157560

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.458

High

1185063

KNL1
Kinetochore scaffold 1

1

0

High-throughput

0.458

High

1185067

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1185069

GLMN
Glomulin

1

0

High-throughput

0.458

High

1185074

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.458

High

1185075

PAWR
PRKC apoptosis WT1 regulator protein

1

0

High-throughput

0.458

High

1185087

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.458

High

1185098

RNF14
E3 ubiquitin-protein ligase RNF14

1

0

Small-scale

0.458

High

1185101

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.458

High

1185105

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.458

High

118756

AIP
AH receptor-interacting protein

1

2

High-throughput

0.437

High

398266

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

4

High-throughput

0.437

High

398366

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.437

High

513593

PYC
Pyruvate carboxylase, mitochondrial

1

4

High-throughput

0.437

High

839947

F10A1
Hsc70-interacting protein

1

5

High-throughput

0.437

High

972536

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

High-throughput

0.437

High

1024040

ACACA
Acetyl-CoA carboxylase 1

1

4

High-throughput

0.437

High

1034912

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.437

High

1067747

PDIA6
Protein disulfide-isomerase A6

1

1

High-throughput

0.437

High

1113799

GRDN
Girdin

1

2

High-throughput

0.437

High

1162505

Q6PK50
Heat shock protein HSP 90-beta

1

3

High-throughput

0.437

High

1185055

PHLB2
Pleckstrin homology-like domain family B member 2

1

1

High-throughput

0.437

High

1185065

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.437

High

1185071

TTC28
Tetratricopeptide repeat protein 28

1

2

High-throughput

0.437

High

1185072

Q96BE0
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.437

High

1185079

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

High-throughput

0.437

High

1185082

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.437

High

1185085

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.437

High

1185090

UN45A
Protein unc-45 homolog A

1

3

High-throughput

0.437

High

1185095

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.437

High

1185106

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.437

High

1131746

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.407

High

396371

APOD
Apolipoprotein D

1

0

High-throughput

0.279

Low

1185102

AT7L1
Ataxin-7-like protein 1

1

0

High-throughput

0.279

Low

1185109

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

0

High-throughput

0.279

Low

50600

PKHG3
Pleckstrin homology domain-containing family G member 3

1

0

High-throughput

0.249

Low

73092

B4DXL2
cDNA FLJ58638, highly similar to Homo sapiens Rho GTPase activating protein 28

1

0

High-throughput

0.249

Low

164946

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.249

Low

166435

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.249

Low

196810

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.249

Low

301412

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

High-throughput

0.249

Low

327189

TXD12
Thioredoxin domain-containing protein 12

1

0

High-throughput

0.249

Low

449303

LEG1
Galectin-1

1

0

High-throughput

0.249

Low

805708

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.249

Low

821285

TCPE
T-complex protein 1 subunit epsilon

1

0

High-throughput

0.249

Low

847295

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low

877588

CAD15
Cadherin-15

1

0

High-throughput

0.249

Low

891550

MYL6
Myosin light polypeptide 6

1

0

High-throughput

0.249

Low

927838

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.249

Low

946554

DCD
Dermcidin

1

0

High-throughput

0.249

Low

953159

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.249

Low

960865

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.249

Low

1085308

FSCN1
Fascin

1

0

High-throughput

0.249

Low

1134346

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.249

Low

1146553

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1167020

LIGO4
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4

1

0

High-throughput

0.249

Low

1173684

VP13C
Intermembrane lipid transfer protein VPS13C

1

0

High-throughput

0.249

Low

1174040

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.249

Low

1185056

NOXA1
NADPH oxidase activator 1

1

0

High-throughput

0.249

Low

1185058

MSRB3
Methionine-R-sulfoxide reductase B3

1

0

High-throughput

0.249

Low

1185062

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

High-throughput

0.249

Low

1185073

KBP
KIF-binding protein

1

0

High-throughput

0.249

Low

1185076

ELMO2
Engulfment and cell motility protein 2

1

0

High-throughput

0.249

Low

1185078

LRRC7
Leucine-rich repeat-containing protein 7

1

0

High-throughput

0.249

Low

1185084

METH
Methionine synthase

1

0

High-throughput

0.249

Low

1185089

OSB10
Oxysterol-binding protein-related protein 10

1

0

High-throughput

0.249

Low

1185091

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.249

Low

1185093

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.249

Low

1185096

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.249

Low

1185097

Q9NWG3
cDNA FLJ10043 fis, clone HEMBA1001085

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024