Protein: NF2L2
Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)

Gene: NF2L2, NFE2L2
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q16236

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001221 - transcription coregulator binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181929

MAFG
Transcription factor MafG

11

19

Small-scale

0.976

High

1081262

MAFF
Transcription factor MafF

8

20

Small-scale

0.970

High

238464

MAFK
Transcription factor MafK

7

20

Small-scale

0.966

High

402074

JUN
Transcription factor Jun

5

17

Small-scale

0.930

High

579266

ATF4
Cyclic AMP-dependent transcription factor ATF-4

3

9

Small-scale

0.866

High

548305

FOSL2
Fos-related antigen 2

1

20

Small-scale

0.778

High

579212

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

Small-scale

0.778

High

862620

FOSB
Protein FosB

1

20

Small-scale

0.778

High

1081254

ZHANG
CREB/ATF bZIP transcription factor

1

6

Small-scale

0.778

High

1049214

KEAP1
Kelch-like ECH-associated protein 1

109

9

Small-scale

0.773

High

1081265

FBW1A
F-box/WD repeat-containing protein 1A

8

20

Small-scale

0.747

High

1081236

CBP
CREB-binding protein

3

20

Small-scale

0.685

High

152491

ENC1
Ectoderm-neural cortex protein 1

3

10

Small-scale

0.678

High

533599

TNNT1
Troponin T, slow skeletal muscle

4

0

High-throughput

0.668

High

1081259

FBW1B
F-box/WD repeat-containing protein 11

3

20

Small-scale

0.664

High

835785

GSK3B
Glycogen synthase kinase-3 beta

3

9

Small-scale

0.651

High

216735

CREB3
Cyclic AMP-responsive element-binding protein 3

1

20

High-throughput

0.647

High

1081213

NFE2
Transcription factor NF-E2 45 kDa subunit

1

20

High-throughput

0.647

High

1081266

NF2L3
Nuclear factor erythroid 2-related factor 3

1

19

High-throughput

0.647

High

1081217

PMF1
Polyamine-modulated factor 1

3

0

Small-scale

0.639

High

1081257

CSN7A
COP9 signalosome complex subunit 7a

2

6

Small-scale

0.629

High

1081248

WAC
WW domain-containing adapter protein with coiled-coil

2

6

High-throughput

0.628

High

1081233

DCA11
DDB1- and CUL4-associated factor 11

2

10

Small-scale

0.624

High

265138

MAF
Transcription factor Maf

1

19

Small-scale

0.618

High

800787

MK08
Mitogen-activated protein kinase 8

2

20

Small-scale

0.611

High

232184

KDM1A
Lysine-specific histone demethylase 1A

2

3

High-throughput

0.606

High

236477

CRBL2
cAMP-responsive element-binding protein-like 2

1

1

Small-scale

0.603

High

276027

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

2

Small-scale

0.603

High

589873

TBP
TATA-box-binding protein

1

1

Small-scale

0.603

High

727145

DDIT3
DNA damage-inducible transcript 3 protein

1

8

Small-scale

0.603

High

776701

STAT3
Signal transducer and activator of transcription 3

1

9

Small-scale

0.603

High

781635

ETV6
Transcription factor ETV6

1

20

Small-scale

0.603

High

794546

ETV4
ETS translocation variant 4

1

20

Small-scale

0.603

High

854730

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

6

Small-scale

0.603

High

862910

CEBPG
CCAAT/enhancer-binding protein gamma

1

20

Small-scale

0.603

High

978771

TF65
Transcription factor p65

1

18

Small-scale

0.603

High

981589

REL
Proto-oncogene c-Rel

1

18

Small-scale

0.603

High

1014256

TEF
Thyrotroph embryonic factor

1

20

Small-scale

0.603

High

134906

IMA3
Importin subunit alpha-3

1

8

Small-scale

0.598

High

1032077

SP140
Nuclear body protein SP140

1

20

Small-scale

0.598

High

1081244

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

3

Small-scale

0.595

High

300539

NFAT5
Nuclear factor of activated T-cells 5

1

18

Small-scale

0.592

High

584250

ELK1
ETS domain-containing protein Elk-1

1

20

Small-scale

0.592

High

840436

ETV1
ETS translocation variant 1

1

20

Small-scale

0.592

High

944616

ELF3
ETS-related transcription factor Elf-3

1

20

Small-scale

0.592

High

1081261

BRPF3
Bromodomain and PHD finger-containing protein 3

1

7

Small-scale

0.592

High

346889

MYC
Myc proto-oncogene protein

2

10

Small-scale

0.584

High

549009

NQO1
NAD(P)H dehydrogenase [quinone] 1

2

1

Small-scale

0.584

High

1041663

CUL3
Cullin-3

2

10

Small-scale

0.584

High

266362

TAD2A
Transcriptional adapter 2-alpha

1

10

Small-scale

0.582

High

501056

IRF1
Interferon regulatory factor 1

1

3

Small-scale

0.582

High

542746

ETS2
Protein C-ets-2

1

20

Small-scale

0.582

High

554457

GATA1
Erythroid transcription factor

1

2

Small-scale

0.582

High

862164

ARFP2
Arfaptin-2

1

1

Small-scale

0.582

High

876951

CASP7
Caspase-7

1

3

Small-scale

0.582

High

924600

GRB2
Growth factor receptor-bound protein 2

1

5

Small-scale

0.582

High

1081221

CF299
Cilia- and flagella-associated protein 299

1

1

Small-scale

0.582

High

1081242

CERS2
Ceramide synthase 2

1

2

Small-scale

0.582

High

1081258

LEF1
Lymphoid enhancer-binding factor 1

1

8

Small-scale

0.582

High

782244

NAA10
N-alpha-acetyltransferase 10

1

1

Small-scale

0.578

High

168931

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.577

High

652868

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

Small-scale

0.573

High

853306

IMA1
Importin subunit alpha-1

1

8

Small-scale

0.568

High

850065

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

13

Small-scale

0.561

High

1026855

MK07
Mitogen-activated protein kinase 7

1

20

Small-scale

0.561

High

1081240

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

3

Small-scale

0.561

High

1081252

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

2

Small-scale

0.561

High

1081269

NCOR2
Nuclear receptor corepressor 2

1

11

Small-scale

0.561

High

431891

HS90A
Heat shock protein HSP 90-alpha

1

10

Small-scale

0.552

High

131445

IMA4
Importin subunit alpha-4

1

8

High-throughput

0.541

High

170381

TIF1A
Transcription intermediary factor 1-alpha

1

20

High-throughput

0.541

High

196615

ZBT24
Zinc finger and BTB domain-containing protein 24

1

10

Small-scale

0.541

High

202185

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

5

Small-scale

0.541

High

536524

IRF2
Interferon regulatory factor 2

1

3

Small-scale

0.541

High

692142

ELF1
ETS-related transcription factor Elf-1

1

20

Small-scale

0.541

High

745185

RBMX
RNA-binding motif protein, X chromosome

1

8

High-throughput

0.541

High

876693

BRPF1
Peregrin

1

6

Small-scale

0.541

High

1031536

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.541

High

1078716

SMAD1
Mothers against decapentaplegic homolog 1

1

15

Small-scale

0.541

High

1081230

SPIC
Transcription factor Spi-C

1

20

Small-scale

0.541

High

1081245

ZN396
Zinc finger protein 396

1

1

Small-scale

0.541

High

1081246

CLIC6
Chloride intracellular channel protein 6

1

3

High-throughput

0.541

High

1081247

ELF4
ETS-related transcription factor Elf-4

1

20

Small-scale

0.541

High

1081260

ELF5
ETS-related transcription factor Elf-5

1

20

Small-scale

0.541

High

521960

CADH1
Cadherin-1

1

0

Small-scale

0.537

High

717863

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.536

High

1081256

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

1

12

Small-scale

0.527

High

487980

RARA
Retinoic acid receptor alpha

1

13

Small-scale

0.515

High

632751

TYY1
Transcriptional repressor protein YY1

1

4

Small-scale

0.515

High

1048079

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

14

High-throughput

0.515

High

1081239

H2B1H
Histone H2B type 1-H

1

6

High-throughput

0.515

High

1081220

ARAID
All-trans retinoic acid-induced differentiation factor

1

0

Small-scale

0.513

High

1081229

PAQR4
Progestin and adipoQ receptor family member 4

1

1

Small-scale

0.512

High

566400

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.501

High

902606

SUMO2
Small ubiquitin-related modifier 2

1

5

Small-scale

0.501

High

928106

SUMO1
Small ubiquitin-related modifier 1

1

5

Small-scale

0.501

High

1017305

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

Small-scale

0.501

High

177307

HDAC3
Histone deacetylase 3

1

16

Small-scale

0.479

High

199118

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

3

Small-scale

0.479

High

261522

NCOR1
Nuclear receptor corepressor 1

1

15

Small-scale

0.479

High

275881

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

3

Small-scale

0.479

High

320208

ERR2
Steroid hormone receptor ERR2

1

9

Small-scale

0.479

High

359983

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

Small-scale

0.479

High

386817

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

428231

TBB5
Tubulin beta chain

1

8

Small-scale

0.479

High

475822

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

Small-scale

0.479

High

529177

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

Small-scale

0.479

High

537650

NCF1
Neutrophil cytosol factor 1

1

3

Small-scale

0.479

High

644048

EF1G
Elongation factor 1-gamma

1

3

Small-scale

0.479

High

659287

DUS1
Dual specificity protein phosphatase 1

1

1

Small-scale

0.479

High

667468

CASP1
Caspase-1

1

3

Small-scale

0.479

High

668721

PML
Protein PML

1

6

Small-scale

0.479

High

681869

AKT1
RAC-alpha serine/threonine-protein kinase

1

10

Small-scale

0.479

High

734942

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

9

Small-scale

0.479

High

749535

BRCA1
Breast cancer type 1 susceptibility protein

1

8

Small-scale

0.479

High

758245

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

Small-scale

0.479

High

800892

MK09
Mitogen-activated protein kinase 9

1

20

Small-scale

0.479

High

819395

GSH1
Glutamate--cysteine ligase catalytic subunit

1

1

Small-scale

0.479

High

819415

GSH0
Glutamate--cysteine ligase regulatory subunit

1

1

Small-scale

0.479

High

846984

SMCA4
Transcription activator BRG1

1

15

Small-scale

0.479

High

851814

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

3

Small-scale

0.479

High

891795

ACTB
Actin, cytoplasmic 1

1

2

Small-scale

0.479

High

917340

H4
Histone H4

1

8

High-throughput

0.479

High

934807

H31
Histone H3.1

1

2

Small-scale

0.479

High

940957

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

Small-scale

0.479

High

972204

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

7

Small-scale

0.479

High

998764

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

1036606

SQSTM
Sequestosome-1

1

3

Small-scale

0.479

High

1038415

HDAC1
Histone deacetylase 1

1

16

Small-scale

0.479

High

1081218

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

7

Small-scale

0.479

High

1081219

PAQR3
Progestin and adipoQ receptor family member 3

1

1

Small-scale

0.479

High

1081223

RN111
E3 ubiquitin-protein ligase Arkadia

1

4

Small-scale

0.479

High

1081224

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.479

High

1081225

RBM45
RNA-binding protein 45

1

4

Small-scale

0.479

High

1081228

HACE1
E3 ubiquitin-protein ligase HACE1

1

13

Small-scale

0.479

High

1081234

IASPP
RelA-associated inhibitor

1

6

Small-scale

0.479

High

1081235

HDAC2
Histone deacetylase 2

1

16

Small-scale

0.479

High

1081238

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

12

Small-scale

0.479

High

1081241

OPTN
Optineurin

1

7

Small-scale

0.479

High

1081250

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

5

Small-scale

0.479

High

1081251

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

12

Small-scale

0.479

High

1081253

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

1081267

DCAF1
DDB1- and CUL4-associated factor 1

1

13

Small-scale

0.479

High

124299

DFFA
DNA fragmentation factor subunit alpha

1

0

Small-scale

0.458

High

548103

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

0

Small-scale

0.458

High

1081227

TRI22
E3 ubiquitin-protein ligase TRIM22

1

0

Small-scale

0.458

High

1081231

G45IP
Large ribosomal subunit protein mL64

1

0

Small-scale

0.458

High

1081255

FGF21
Fibroblast growth factor 21

1

0

Small-scale

0.458

High

50592

PKHG3
Pleckstrin homology domain-containing family G member 3

1

1

High-throughput

0.445

High

164623

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

6

High-throughput

0.445

High

216060

NRDC
Nardilysin

1

4

High-throughput

0.445

High

279573

FLOT1
Flotillin-1

1

2

High-throughput

0.445

High

297353

MYO1D
Unconventional myosin-Id

1

3

High-throughput

0.445

High

313834

SVIL
Supervillin

1

3

High-throughput

0.445

High

433367

YES
Tyrosine-protein kinase Yes

1

2

High-throughput

0.445

High

436092

ANXA6
Annexin A6

1

5

High-throughput

0.445

High

436983

DAF
Complement decay-accelerating factor

1

2

High-throughput

0.445

High

503289

MTAP2
Microtubule-associated protein 2

1

7

High-throughput

0.445

High

505643

EPB41
Protein 4.1

1

3

High-throughput

0.445

High

527993

RINI
Ribonuclease inhibitor

1

1

High-throughput

0.445

High

671665

PEBP1
Phosphatidylethanolamine-binding protein 1

1

1

High-throughput

0.445

High

807739

MAP1B
Microtubule-associated protein 1B

1

6

High-throughput

0.445

High

963338

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

7

High-throughput

0.445

High

1045425

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

8

High-throughput

0.445

High

1052407

FLOT2
Flotillin-2

1

2

High-throughput

0.445

High

1068541

PLEC
Plectin

1

5

High-throughput

0.445

High

1081214

DREB
Drebrin

1

2

High-throughput

0.445

High

1081215

CYTSB
Cytospin-B

1

7

High-throughput

0.445

High

1081216

FA83B
Protein FAM83B

1

1

High-throughput

0.445

High

1081222

MPRIP
Myosin phosphatase Rho-interacting protein

1

5

High-throughput

0.445

High

1081264

COF2
Cofilin-2

1

3

High-throughput

0.445

High

1081243

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

2

Small-scale

0.437

High

121162

LEG8
Galectin-8

1

0

High-throughput

0.426

High

274094

XRP2
Protein XRP2

1

0

High-throughput

0.426

High

441611

TRFM
Melanotransferrin

1

0

High-throughput

0.426

High

452233

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.426

High

489967

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

High-throughput

0.426

High

682506

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

High-throughput

0.426

High

1081226

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.426

High

1081232

FBX30
F-box only protein 30

1

0

High-throughput

0.426

High

1081263

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.426

High

1081268

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

531842

PDIA4
Protein disulfide-isomerase A4

1

8

High-throughput

0.407

High

945672

NGAL
Neutrophil gelatinase-associated lipocalin

1

2

High-throughput

0.407

High

1081237

COR2A
Coronin-2A

1

10

High-throughput

0.407

High

147130

ASTN1
Astrotactin-1

1

0

Small-scale

0.249

Low

1081249

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024