Protein: SIRT1
NAD-dependent histone deacetylase sirtuin-1 (EC 2.3.1.286) (Silent information regulator 2)

Gene: SIRT1
Organism: Drosophila melanogaster
Interactions: 27
UniProt ID: Q9VK34

Gene Ontology (top 5):
GO:0001223 - transcription coactivator binding
GO:0002039 - p53 binding
GO:0003714 - transcription corepressor activity
GO:0004407 - histone deacetylase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

569366

HAIR
Protein hairy

2

5

Small-scale

0.552

High

1175931

DPN
Protein deadpan

2

6

Small-scale

0.552

High

467197

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.508

High

565038

ATNA
Sodium/potassium-transporting ATPase subunit alpha

1

3

High-throughput

0.508

High

1263047

Q7JXC4
CG6459 protein

1

1

High-throughput

0.508

High

1479072

Q9VKC5
RH17958p

1

0

High-throughput

0.486

High

122002

M9PH39
histone acetyltransferase

1

13

Small-scale

0.479

High

892168

HNF4
Transcription factor HNF-4 homolog

1

12

Small-scale

0.479

High

1445173

Q9N6D8
GH11591p

1

6

Small-scale

0.479

High

1471465

Q9VDE3
LD08669p

1

6

High-throughput

0.479

High

1479074

Q9VPL9
FI24801p1

1

11

Small-scale

0.479

High

1479076

Q9W1G7
LD21576p

1

4

Small-scale

0.479

High

1479078

Q9W2S2
Autophagy-related 8a, isoform A

1

5

Small-scale

0.479

High

458126

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.464

High

1262344

Q7JVY0
Coronin

1

2

High-throughput

0.464

High

1479073

HEAT1
HEAT repeat-containing protein 1 homolog

1

1

High-throughput

0.464

High

701306

SUH
Suppressor of hairless protein

1

0

Small-scale

0.458

High

1479077

Q9W1K4
Egalitarian, isoform B

1

0

High-throughput

0.458

High

119161

M9NFI9
Neurabin-1

1

3

High-throughput

0.445

High

356869

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

13

High-throughput

0.445

High

1479075

Q9W0L7
ubiquitinyl hydrolase 1

1

2

High-throughput

0.445

High

52615

A1Z720
Uncharacterized protein, isoform A

1

1

High-throughput

0.439

High

1377935

KCMF1
E3 ubiquitin-protein ligase Kcmf1

1

3

High-throughput

0.439

High

55254

A1Z995
Sequoia, isoform A

1

0

High-throughput

0.426

High

52620

A1Z722
Uncharacterized protein, isoform O

1

7

High-throughput

0.417

High

144550

O01368
histone acetyltransferase

1

11

High-throughput

0.381

High

304699

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025