Protein: MED15
Mediator of RNA polymerase II transcription subunit 15 (Mediator complex subunit 15) (dARC105)

Gene: MED15
Organism: Drosophila melanogaster
Interactions: 87
UniProt ID: Q9Y149

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
GO:0030707 - follicle cell of egg chamber development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1267084

MED29
Mediator of RNA polymerase II transcription subunit 29

2

1

High-throughput

0.737

High

1489654

MED23
Mediator of RNA polymerase II transcription subunit 23

1

3

High-throughput

0.618

High

1489731

MED16
Mediator of RNA polymerase II transcription subunit 16

1

1

High-throughput

0.618

High

674074

BRM
ATP-dependent helicase brm

2

18

High-throughput

0.571

High

900695

DSH
Segment polarity protein dishevelled

2

3

High-throughput

0.571

High

1019313

MED20
Mediator of RNA polymerase II transcription subunit 20

2

1

High-throughput

0.571

High

1269652

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.571

High

1321596

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.571

High

1472600

Q9VEB9
Sequence-specific single-stranded DNA-binding protein, isoform A

2

5

High-throughput

0.571

High

1473462

Q9VF03
Brahma associated protein 155 kDa

2

13

High-throughput

0.571

High

1485972

CDK8
Cyclin-dependent kinase 8

2

9

High-throughput

0.571

High

1488722

BAP60
Brahma-associated protein of 60 kDa

2

3

High-throughput

0.571

High

1490402

MED18
Mediator of RNA polymerase II transcription subunit 18

2

1

High-throughput

0.571

High

1261450

Q7JQT8
LD41464p

2

0

High-throughput

0.559

High

1377892

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

2

6

High-throughput

0.542

High

1321541

ENC
Protein encore

2

7

High-throughput

0.521

High

263762

CHK1
Serine/threonine-protein kinase grp

1

1

High-throughput

0.508

High

304902

E2F2
Transcription factor E2F2

1

6

High-throughput

0.508

High

356704

PLK4
Serine/threonine-protein kinase PLK4

1

7

High-throughput

0.508

High

575875

CCNA
G2/mitotic-specific cyclin-A

1

6

High-throughput

0.508

High

660491

CDK2
Cyclin-dependent kinase 2

1

4

High-throughput

0.508

High

837199

MAD
Protein mothers against dpp

1

20

High-throughput

0.508

High

1303772

AKT1
RAC serine/threonine-protein kinase

1

11

High-throughput

0.508

High

1378217

CYCG
Cyclin G

1

5

High-throughput

0.508

High

1478525

Q9VJJ0
Proteasome subunit beta

1

1

High-throughput

0.508

High

1479894

PIE
Pineapple eye protein

1

8

High-throughput

0.508

High

1489124

Q9VZP3
Cyclin J, isoform A

1

7

High-throughput

0.508

High

1489606

Q9W1J7
SKP1 component POZ domain-containing protein

1

1

High-throughput

0.508

High

1489835

ERK7
Extracellular signal-regulated kinase 7

1

6

High-throughput

0.508

High

2379

A0A0B4KEQ7
Regulatory protein zeste

1

1

High-throughput

0.494

High

1267200

Q7KJ69
GEO01805p1

1

0

High-throughput

0.486

High

1268588

Q7KPG8
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.486

High

118235

M9NCT1
SET and MYND domain containing, arthropod-specific, member 3, isoform C

1

1

High-throughput

0.481

High

122017

M9PH39
histone acetyltransferase

1

14

High-throughput

0.481

High

1216721

Q5U0V6
Cell division cycle 14, isoform B

1

4

High-throughput

0.481

High

1266119

Q7K3Q3
Regulatory protein zeste

1

1

High-throughput

0.481

High

1269928

Q7KUZ5
Cyclin D, isoform D

1

11

High-throughput

0.481

High

1439978

SIRT2
NAD-dependent protein deacetylase Sirt2

1

9

High-throughput

0.481

High

58526

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

High-throughput

0.479

High

628552

USP
Protein ultraspiracle

1

20

Small-scale

0.479

High

756516

ECR
Ecdysone receptor

1

20

Small-scale

0.479

High

1192935

YAP1
Transcriptional coactivator yorkie

1

13

Small-scale

0.479

High

1377823

EBI
F-box-like/WD repeat-containing protein ebi

1

7

High-throughput

0.479

High

1428016

MED10
Mediator of RNA polymerase II transcription subunit 10

1

1

High-throughput

0.479

High

1428123

MED7
Mediator of RNA polymerase II transcription subunit 7

1

1

High-throughput

0.479

High

1472627

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.479

High

1482753

MED27
Mediator of RNA polymerase II transcription subunit 27

1

1

High-throughput

0.479

High

1484632

Q9VR42
Serine/threonine-protein kinase RIO3

1

1

High-throughput

0.479

High

1485359

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.479

High

1485626

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

19

High-throughput

0.479

High

1487446

MED11
Mediator of RNA polymerase II transcription subunit 11

1

1

High-throughput

0.479

High

1489436

MED30
Mediator of RNA polymerase II transcription subunit 30

1

1

High-throughput

0.479

High

1489445

MED14
Mediator of RNA polymerase II transcription subunit 14

1

11

High-throughput

0.479

High

1306677

SIR4
NAD-dependent protein deacylase Sirt4

1

9

High-throughput

0.464

High

1320963

Q8MQJ7
Autophagy-related 1, isoform B

1

3

High-throughput

0.464

High

1439961

Q9I7I1
CLIP domain-containing serine protease

1

2

High-throughput

0.464

High

1482649

POLZ2
DNA polymerase zeta subunit 2

1

2

High-throughput

0.464

High

1480286

Q9VL29
GEO11246p1

1

0

High-throughput

0.458

High

885681

MNB
Serine/threonine-protein kinase minibrain

1

18

High-throughput

0.457

High

1378312

Q95TP4
LD33277p

1

1

High-throughput

0.457

High

1427811

Q9GTQ8
Cyclin D

1

11

High-throughput

0.457

High

1479716

Q9VKN9
RE12806p

1

1

High-throughput

0.457

High

1481306

Q9VLW7
Cell division cycle 14, isoform A

1

1

High-throughput

0.457

High

1377767

Q95RJ1
LD27667p

1

1

High-throughput

0.451

High

1489162

Q9VZV3
PAN2-PAN3 deadenylation complex subunit PAN3

1

9

High-throughput

0.451

High

56968

A1ZAK7
LD35640p

1

7

High-throughput

0.445

High

197504

O18353
CHIP

1

1

High-throughput

0.445

High

1171951

Q24090
GH08712p

1

3

High-throughput

0.445

High

1263914

Q7K012
Brahma associated protein 55kD

1

9

High-throughput

0.445

High

1343943

Q8SXP8
TAR DNA-binding protein 43

1

8

High-throughput

0.445

High

1487595

MED12
Mediator of RNA polymerase II transcription subunit 12

1

19

High-throughput

0.445

High

53267

A1Z7L5
Uncharacterized protein, isoform E

1

1

High-throughput

0.439

High

69229

A8JUS8
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

1488449

Q9VXR9
FI03680p

1

1

High-throughput

0.439

High

1378970

Q960F7
SD03629p

1

4

High-throughput

0.437

High

1486614

Q9VUB7
PAX-interacting protein 1

1

15

High-throughput

0.437

High

1489406

Q9W0L7
ubiquitinyl hydrolase 1

1

3

High-throughput

0.437

High

638683

MAM
Neurogenic protein mastermind

1

0

High-throughput

0.426

High

1344724

Q8SYZ4
NAD-dependent protein deacetylase

1

9

High-throughput

0.417

High

1379484

Q961V9
GH03273p

1

1

High-throughput

0.417

High

1490108

Q9W5G0
LD08762p

1

1

High-throughput

0.417

High

1031668

UMPS
Uridine 5'-monophosphate synthase

1

1

High-throughput

0.407

High

1069952

Q0E996
Eukaryotic translation initiation factor 4 gamma 2

1

3

High-throughput

0.407

High

1489671

Q9W218
GEO08374p1

2

0

High-throughput

0.310

High

1346472

MESD
LDLR chaperone boca

2

0

High-throughput

0.298

High

1269159

Q7KT57
HDC02844

1

0

High-throughput

0.251

Low

1488893

Q9VYZ8
GEO08286p1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025